Investigating the prevalence of risk factors of papillary thyroid carcinoma recurrence and disease-free survival after thyroidectomy and central neck dissection in Iranian patients

Arianpoor, Arash; Asmar, M; Amini, Elahe; Ziaeemehr, Aghigh; Simab, Saeideh Ahmadi

doi:10.1080/00015458.2019.1576447

Cited by 15 publications

(12 citation statements)

References 11 publications

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“…PTC derived from follicular cells is considered to be the most common malignant thyroid tumor, mostly occurring between 30 and 40 years old, and its 10-year survival rate is above 95% (38). However, PTC is also a common thyroid cancer that is considered to be the biological characteristic of metastasizing to the surrounding neck lymph nodes (39).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

et al. 2020

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Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients. Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020. Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14-2.01, p < 0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51-1.87, p < 0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45-2.89, p < 0.0001); tumor size ≥1.0 cm (pooled OR = 3.53, 95% CI = 2.62-4.76, p < 0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04-2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69-7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78-2.31, p < 0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54-1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79-1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients. Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

et al. 2020

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“…Thyroid nodules are identified in the majority of patients using B-mode ultrasound during physical examination, and diagnosis is confirmed following histopathological examination ( 3 ). Generally, the survival rate of patients without metastasis of papillary thyroid carcinoma is >80% at 10 years following surgical treatment ( 4 ). However, in patients with lymph node metastasis, the tumor cannot be completely removed by surgery, thus the prognosis following palliative treatment remains poor ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression

Chen

Huang

2021

Mol Med Rep

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Papillary thyroid carcinoma is a common malignant tumor of the endocrine system. The specific role and molecular mechanism of potassium inwardly rectifying channel subfamily J member 2 (KCNJ2) in papillary thyroid carcinoma remain unknown. In the present study, the underlying mechanism of KCNJ2 in papillary thyroid carcinoma was explored. KCNJ2 expression in thyroid cancer tissues was predicted using the Gene Expression Profiling Interactive Analysis database, and reverse transcription-quantitative PCR and western blot analyses were performed to detect KCNJ2 expression in papillary thyroid carcinoma cell lines. Cell transfection was performed to inhibit KCNJ2 and G protein subunit γ2 (GNG2) expression. In addition, cell proliferation was detected via the colony formation and MTT assays. The wound healing and Transwell assays were performed to assess cell migration and invasion, respectively. Western blot analysis was performed to detect the expression levels of transport-related proteins and interstitial related proteins. The StarBase database was used to detect GNG2 expression in thyroid cancer. The results demonstrated that KCNJ2 expression was upregulated in papillary thyroid carcinoma cells. In addition, interfering with KCNJ2 expression inhibited the proliferation, invasion and migration of papillary thyroid carcinoma cells, and inhibited the epithelial-to-mesenchymal transition (EMT). These processes may be influenced by the upregulation of GNG2 expression induced by KCNJ2 knockdown. Overall , the results of the present study demonstrated that interference with KCNJ2 inhibited proliferation, migration and EMT progression of papillary thyroid carcinoma cells by upregulating GNG2 expression.

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“…Tumor metastasis is one of the most important prognostic factors in solid tumors and survival of head and neck squamous cell carcinoma (HNSCC) is strongly affected by cervical lymph node metastasis (1,2). HNSCC prevalence accounts for approximately 5% of all cancer types; however, in Iran, it seems to be 1% (3). cervical lymphadenopathy (LAP) in upper aerodigestive tract decreases the 5-year survival about 50% (4).…”

Section: Introductionmentioning

confidence: 99%

The Use of Neck Sonography in Identifying Cervical Lymph Node: A Single Center Study from 2019 to 2020

Motamedfar¹,

Gharibvand²,

Sametzade³

et al. 2021

Jundishapur J Chronic Dis Care

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Background: Tumor metastasis, as one of the most important prognostic factors in solid tumors, affects survival remarkably. Cervical lymphadenopathy (LAP) reflects an advanced-stage disease and changes the tumor-node-metastasis (TNM) staging of tumor, resulting in a multidisciplinary approach to the management of cancer. Objectives: This study aimed to assess the importance of neck sonography in monitoring primary tumors. Methods: Records of 166 patients with distant primary cancers who underwent neck sonography from February 2019 to February 2020 were studied. Abnormal lymph nodes were reported, and then the patients underwent neck sonography and fine needle aspiration (FNA) or core needle biopsy (CNB) under direct US guidance. Thirty-two patients who were confirmed for malignant cervical LAP underwent neck lymph node biopsy as an easy and safe way to provide tissue diagnosis instead of providing biopsy from the primary source of tumor. Results: Malignant cervical LAP was confirmed in 32 patients (19.2%) by neck sonography. Seventy-seven patients (46.4%) were male and 89 patients (53.6%) were female. The patients were 22 to 88 years old (mean age = 57.7 years; standard deviation = 12.7). Thirty-two patients (19.2%) had pathological cervical lymph nodes and 134 patients (80.8%) did not have. Conclusions: Metastatic cervical LAP found by neck ultrasound will change pretreatment TNM staging of disease to provide optimal treatment on a case-by-case basis. According to the result of this study, routine neck sonography in patients with distant primary tumors is recommended.

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Investigating the prevalence of risk factors of papillary thyroid carcinoma recurrence and disease-free survival after thyroidectomy and central neck dissection in Iranian patients

Cited by 15 publications

References 11 publications

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression

The Use of Neck Sonography in Identifying Cervical Lymph Node: A Single Center Study from 2019 to 2020

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