Prediction of academic success at post-secondary institutions is an enduring issue for educational psychology. Traditional measures of high-school grade point average and high-stakes entrance examinations are valid predictors, especially of first-year college grades, yet a large amount of individual-differences variance remains unaccounted for. Studies of individual trait measures (e.g., personality, self-concept, motivation) have supported the potential for broad predictors of academic success, but integration across these approaches has been challenging. The current study tracks 589 undergraduates from their first semester through attrition or graduation (up to 8 years beyond their first semester). Based on an integrative trait-complex approach to assessment of cognitive, affective, and conative traits, patterns of facilitative and impeding roles in predicting academic success were predicted. We report on the validity of these broad trait complexes for predicting academic success (grades and attrition rates) in isolation, and in the context of traditional predictors and indicators of domain knowledge (Advanced Placement® exams). We also examine gender differences and trait complex by gender interactions for predicting college success and persistence in STEM fields. Inclusion of trait-complex composite scores and average AP exam scores raised the prediction variance accounted for in college grades to 37%, a marked improvement over traditional prediction measures. Math/Science SelfConcept and Mastery/Organization trait complex profiles were also found to differ between men and women who had initial STEM major intentions, but who left STEM for non-STEM majors.Implications for improving selection and identification of students at-risk for attrition are discussed. According to recent statistics (National Center for Educational Statistics, 2012), the overall attrition rate in Title IV institutions is 28.1% (Title IV institutions are those that are allowed to participate in Pell Grants and other federal financial assistance programs). That is, more than 1 in 4 first-time degree/certificate seeking undergraduate students fail to complete a degree within 6 years. At public 4-year institutions, the overall attrition rate is lower (21.4%), but still represents a major concern to institutions and stakeholders (e.g., students, parents, state and federal policy-makers). Although the situation may not be as stark as the statistics indicate because reported attrition rates include transfers from one institution to another, the loss of students prior to completing a degree represents a failure in either the selection of students, or a failure to identify students and to provide interventions for students who are at-risk for attrition.It might be pointed out, however, that attritions do also include students who realize that they are not well-matched to an institution, or who find that they are not ultimately interested in completing a degree. Whether these latter situations can be regarded as selection failures is an o...