Investigating the Migraine Cycle over 21 Consecutive Days Using Proton Magnetic Resonance Spectroscopy and Resting-State fMRI: A Pilot Study

Filippi, Vera; Steiger, Ruth; Beliveau, Vincent; Frank, Florian; Kaltseis, Katharina; Gizewski, Elke R.; Broessner, Gregor

doi:10.3390/brainsci12050646

Cited by 4 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study using fMRI in 32 patients with migraine during the interictal phase found altered global sensory processing in the pain-free state, providing a neurophysiological basis for a potentially altered auditory, gustatory, motor and somatosensory processing ( 87 ). A proton magnetic resonance spectroscopy (1H-MRS) and fMRI daily in one patient for 21 days identified interictal abnormalities that could suggest an increased susceptibility to excitatory migraine triggers ( 88 ).…”

Section: “Objective” Interictal Findingsmentioning

confidence: 99%

The not so hidden impact of interictal burden in migraine: A narrative review

et al. 2022

View full text Add to dashboard Cite

Migraine is a highly prevalent neurological disease of varying attack frequency. Headache attacks that are accompanied by a combination of impact on daily activities, photophobia and/or nausea are most commonly migraine. The headache phase of a migraine attack has attracted more research, assessment tools and treatment goals than any other feature, characteristic, or phase of migraine. However, the migraine attack may encompass up to 4 phases: the prodrome, aura, headache phase and postdrome. There is growing recognition that the burden of migraine, including symptoms associated with the headache phase of the attack, may persist between migraine attacks, sometimes referred to as the “interictal phase.” These include allodynia, hypersensitivity, photophobia, phonophobia, osmophobia, visual/vestibular disturbances and motion sickness. Subtle interictal clinical manifestations and a patient's trepidation to make plans or commitments due to the unpredictability of migraine attacks may contribute to poorer quality of life. However, there are only a few tools available to assess the interictal burden. Herein, we examine the recent advances in the recognition, description, and assessment of the interictal burden of migraine. We also highlight the value in patients feeling comfortable discussing the symptoms and overall burden of migraine when discussing migraine treatment needs with their provider.

show abstract

Section: “Objective” Interictal Findingsmentioning

confidence: 99%

The not so hidden impact of interictal burden in migraine: A narrative review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In a comprehensive review spanning fMRI studies from 2014 to 2021, only a small fraction (9 out of 114) included data partially collected during the ictal phase, and often the cycle phases were poorly defined (Schramm et al, 2023). Moreover, only 14 FC studies sampled more than one phase, and of these only 9 were longitudinal (Amin et al, 2018; Araújo et al, 2023; Filippi et al, 2022; Marciszewski et al, 2018; Meylakh et al, 2018; Schulte, Menz, et al, 2020; Schulte & May, 2016; Stankewitz et al, 2021; Stankewitz & Schulz, 2022), with some of them relying on the same sample and including 2 case studies. Furthermore, only 3 of the longitudinal studies sampled all migraine cycle phases and they did not compare them with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Multilevel clinical fingerprinting: uncovering longitudinal changes in the functional connectome of the brain along the migraine cycle

Esteves,

Fouto,

Ruiz-Tagle

et al. 2024

Preprint

View full text Add to dashboard Cite

Migraine is a common neurological disorder characterized by recurrent headache episodes alternating with symptom-free periods, which has been associated with alterations across large-scale functional brain networks albeit with variable findings. Critically, despite the cyclic nature of the disorder, longitudinal studies spanning the various phases of the migraine cycle are scarce. Here, we leverage the identifiability of individual functional connectomes (FC) to investigate changes along the migraine cycle. For this purpose, we employ a case-control longitudinal design to study a group of 10 patients with episodic menstrual or menstrual-related migraine without aura, in the 4 phases of their spontaneous migraine cycle (preictal, ictal, postictal, interictal), and a group of 14 healthy controls in corresponding phases of the menstrual cycle, using resting-state fMRI. We propose a novel multilevel clinical fingerprinting approach to analyse the differential FC identifiability within-subject, as well as within-session and within-group. The individual FC matrices are then reconstructed with 19 principal components maximizing identifiability at all levels, and analyzed with Network-Based Statistic to identify significant changes in FC strength. We observe decreased FC identifiability for patients in the preictal phase relative to controls, which increases with the progression of the attack and becomes comparable to controls in the interictal phase. Regarding the FC strength, is increased in the ictal and postictal phases relative to controls across several networks. Our novel multilevel clinical fingerprinting approach captures FC variations along the migraine cycle in a case-control longitudinal study, bringing new insights into the cyclic nature of the disorder.

show abstract

“…One study using functional brain MRI documented an altered global sensory processing during the interictal state in patients with migraine without aura [ 14 ]. Recently, a very interesting study has been published, in which the authors followed for 21 days one episodic patient via proton magnetic resonance spectroscopy (1H-MRS) and functional resting state MRI daily [ 15 ]. The main outcome of this study is that changes in N-acetyl aspartate (NAA) levels were associated with altered mitochondrial metabolism and thus abnormal energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

Migraine Disability Improvement during Treatment with Galcanezumab in Patients with Chronic and High Frequency Episodic Migraine

Cola

Bolchini

Caratozzolo

et al. 2023

Neurology International

View full text Add to dashboard Cite

Background: The aim of the present study was to assess the migraine outcome, in particular migraine disability, in chronic (CM) and high frequency episodic migraine (HFEM) patients in treatment with galcanezumab. Methods: The present study was conducted at the Headache Centre of Spedali Civili of Brescia. Patients were treated with galcanezumab 120 mg monthly. Clinical and demographical information were collected at the baseline (T0). Data about outcome, analgesics consumption and disability (MIDAS and HIT-6 scores) were collected quarterly. Results: Fifty-four consecutive patients were enrolled. Thirty-seven patients had a diagnosis of CM, 17 of HFEM. During treatment, patients reported a significant reduction in terms of mean headache/migraine days (p < 0.001), the attacks’ pain intensity (p = 0.001) and monthly consumed analgesics (p < 0.001). The MIDAS and HIT-6 scores also documented a significant improvement (p < 0.001). At the baseline, all patients documented a severe degree of disability (MIDAS score ≥ 21). Following six months of treatment, only 29.2% of patients still documented a MIDAS score ≥ 21, with one third of patients documenting little or no disability. A > 50% MIDAS reduction, compared to baseline, was observed in up to 94.6% of patients, following the first three months of treatment. A similar outcome was found for HIT-6 scores. A significant positive correlation was found between headache days and MIDAS at T3 and T6 (T6 > T3), but not baseline. Discussion: Monthly prophylactic treatment with galcanezumab was found to be effective in both CM and HFEM, especially in reducing migraine burden and disability.

show abstract

Investigating the Migraine Cycle over 21 Consecutive Days Using Proton Magnetic Resonance Spectroscopy and Resting-State fMRI: A Pilot Study

Cited by 4 publications

References 32 publications

The not so hidden impact of interictal burden in migraine: A narrative review

The not so hidden impact of interictal burden in migraine: A narrative review

Multilevel clinical fingerprinting: uncovering longitudinal changes in the functional connectome of the brain along the migraine cycle

Migraine Disability Improvement during Treatment with Galcanezumab in Patients with Chronic and High Frequency Episodic Migraine

Contact Info

Product

Resources

About