Investigating the knowledge, perception, and practice of healthcare practitioners toward rational use of compounded medications and its contribution to antimicrobial resistance: a cross-sectional study

Assefa, Desta; Paulos, Getahun; Kebebe, Dereje; Alemu, Sintayehu; Demissie, Wondu Reta; Mulugeta, Temesgen; Gashe, Fanta

doi:10.1186/s12913-022-07649-4

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…Analogous concerns emerged in a recent study of knowledge, perception, and practice of healthcare practitioners toward compounded medications, notably antimicrobial products, almost half of respondents believed that compounded medications might lack quality and have poor patient compliance. 37 Additionally, a majority expressed concerns regarding potentially inappropriate preparation processes and under-dose administration of compounded medications, with a fear this might contribute to antimicrobial resistance. Whatever the trends in compounding, our study, and others, show that the practice seems destined to stay, in one guise or another.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the type and frequency of extemporaneous formulations dispensed in hospital and community pharmacies

Ramtoola,

Catibusic,

Ameen

et al. 2023

Exploratory Research in Clinical and Social Pharmacy

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Section: Discussionmentioning

confidence: 99%

Evaluation of the type and frequency of extemporaneous formulations dispensed in hospital and community pharmacies

Ramtoola,

Catibusic,

Ameen

et al. 2023

Exploratory Research in Clinical and Social Pharmacy

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“…A cross-sectional study in Ethiopia with 300 participants including physicians and pharmacists indicated inconsistency of compounded medication quality. Respondents strongly believed that poor quality extemporaneous antimicrobials contribute to anti-microbial resistance development (Assefa et al, 2022). Many pharmacies and institutions develop their own formulary for the frequently compounded products, but this is not sufficient to reduce the possibility of error (Smith et al, 2019).…”

Section: Quality Assurance Of Extemporaneous Preparationsmentioning

confidence: 99%

Extemporaneous Compounding: Prevalence, Risks and Quality Assurance

Vugigi

2023

AJPAM

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Extemporaneously compounded products are designed for an individual patient based on a licensed physician’s prescription in response to an identified need. Compounding provides medications for unique medical needs for which commercially manufactured products are unavailable. Compounding practice includes activities such as formulating, mixing, or repacking products. Extemporaneous preparations are not licensed by Drug Regulatory Authorities and hence, are not evaluated for quality, efficacy, and stability. Also, adverse event reporting is not mandatory for these products. The need for extemporaneous preparations is precipitated by a lack of commercially available products for all the medicines and dosage forms that are required by patients. Products intended for topical and pediatric use are the majority. Extemporaneous preparations are generally considered as high-risk products. Common risks of compounded products include calculation errors, microbial contamination, therapeutic failure, and adverse reactions. To reduce the risks, Drug Regulatory Authorities havedeveloped guidelines that describe the minimum standards to be followed when preparing for extemporaneous compounding to ensure product quality and fitness. A comprehensive assessment is performed to justify the need for these products. The preparation process should comply with all the Good Manufacturing Practices including design of compounding areas. Pharmacists performing compounding activities require appropriate knowledge, skills, and competence to undertake the task. The ingredients used in compounding are subject to pharmacopeial quality standards and should be sourced from approved vendors. The final compounded product in some countries is controlled as stipulated in the components standard. Extemporaneous compounding remains an important part of pharmacy practice. Comprehensive risk assessment, adherence to the prescribed manufacturing practices, and use of national formularies are necessary for quality assurance of these preparations.

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“…Inappropriately compounded medication results in the administration of insufficient doses and contaminated drugs, which can cause ineffectiveness or toxicity (Assefa et al. 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of traditional healers’ knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia

Workie Limenh,

Emagn Kasahun,

Ayalew Tessema

et al. 2024

Pharmaceutical Biology

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Context Although pharmaceutical equipment and medical supplies play a vital role in the quality of traditional medicines, they have not received much attention from stakeholders and researchers nationally and internationally. Objective This study assesses traditional healers’ knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia. Materials and methods A quantitative cross-sectional study was conducted on 70 traditional healers. The data were collected using an interview-based questionnaire. The collected data were checked and entered into Statistical Package for Social Sciences version 25.0 for analysis. The results were presented as percentages. The association between socio-demographic characteristics and traditional healers’ knowledge of pharmaceutical equipment and medical supplies was examined using Pearson’s Chi-squares test. Results About 90% of traditional healers had information about pharmaceutical equipment and medical supplies, and currently 80% of them used different pharmaceutical equipment and medical supplies individually and in combination with traditional equipment. Although most traditional healers used different pharmaceutical equipment and medical supplies, only 13.3% of them used equipment and supplies a day. Only 15% of traditional healers continuously cleaned their equipment. None of the socio-demographic variables were significantly associated to the knowledge of pharmaceutical equipment and medical supplies. Discussion and Conclusions Pharmaceutical equipment and medical supplies used by traditional healers was inconsistent, mainly associated with their habit of using self-prepared and home-available equipment. Moreover, the checkup status of compounding equipment was poor. As Traditional healers provide high-patient care services, emphasis should be given to improving their preparation and treatment strategies.

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Investigating the knowledge, perception, and practice of healthcare practitioners toward rational use of compounded medications and its contribution to antimicrobial resistance: a cross-sectional study

Cited by 8 publications

References 18 publications

Evaluation of the type and frequency of extemporaneous formulations dispensed in hospital and community pharmacies

Evaluation of the type and frequency of extemporaneous formulations dispensed in hospital and community pharmacies

Extemporaneous Compounding: Prevalence, Risks and Quality Assurance

Assessment of traditional healers’ knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia

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