Investigating the Frequency of the ERCC1 Gene C8092A Polymorphism in Iranian Patients with Advanced Gastric Cancer

Mokmeli, Sharareh; Tehrani, Golnaz Asaadi; Zamiri, Reza; Bahrami, Tayyeb

doi:10.7314/apjcp.2016.17.3.1369

Asian Pacific Journal of Cancer Prevention

2016

DOI: 10.7314/apjcp.2016.17.3.1369

|View full text |Cite

Investigating the Frequency of the ERCC1 Gene C8092A Polymorphism in Iranian Patients with Advanced Gastric Cancer

Sharareh Mokmeli

Golnaz Asaadi Tehrani²,

Reza Zamiri³

et al.

Abstract: Background: Platinum compounds are the main drugs for treatment of advanced gastric cancer. Previous studies have shown that clinical outcome with platinum-based compounds depends on ERCC1 polymorphisms. The aim of this study was to investigate the frequency of a common polymorphism of ERCC1 gene (C8092A) in Iranian patients with advanced gastric cancer receiving platinum chemotherapy. Materials and Methods: Genetic analysis of the ERCC1 C8092A polymorphism was performed by the PCR -RFLP method using 50 paraff… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

<p>Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review</p>

Farmanfarma¹,

Mahdavifar²,

Hassanipour³

et al. 2020

CEG

View full text Add to dashboard Cite

Background Gastric cancer (GC) is one of the most common cancers in Iran. Knowledge of the epidemiology of the disease is essential in planning for prevention. So this study aimed to investigate the epidemiological aspects of gastric cancer including prevalence, incidence, mortality, and risk factors of Iran. Methods This systematic review study was based on articles published in both English and Persian languages during the years of 1970–2020 in international databases (PubMed, Web of Science, Scopus) and national databases (including SID, Magiran, and IranDoc). Papers related to epidemiological aspects of the disease including mortality, prevalence, incidence, and risk entered the final review. Results According to the studies, the minimum and maximum prevalence of gastric cancer in northwestern Iran (Ardabil) is between 0.2 and 100 per 100,000. Also, the death rate per 100,000 people ranged from 10.6 to 15.72 and the ASMR ranged from 4.2 to 32.2%. On the other hand, the incidence of GC was higher in men than in women (74.9 vs 4.6%). The GC risk ratio was 8-times higher in the elderly than in the other age groups (HR=8.0, 2.7–23.5). The incidence of gastric cancer in patients with H. pylori infection was 18-times and that of smokers 2-times higher than other populations. Low level of economic situation and food insecurity increased the odds of GC by 2.42- and 2.57-times, respectively. It should be noted that there was a direct relationship between consumption of processed red meat, dairy products, fruit juice, smoked and salty fish and legumes, strong and hot tea, and consumption of salt and gastric cancer incidence. There was also an inverse relationship between citrus consumption, fresh fruit, garlic, and gastric cancer. In addition, the mRNA genes are the most GC-related genes. Conclusion Given the high incidence of GC in Iran, changing lifestyle and decreasing consumption of preservatives in food, increasing consumption of fruits and vegetables, and improving the lifestyle can be effective in reducing the incidence of this disease.

show abstract

<p>Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review</p>

Farmanfarma¹,

Mahdavifar²,

Hassanipour³

et al. 2020

CEG

View full text Add to dashboard Cite

show abstract

The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk

Chen

Shen

et al. 2020

Cancer Genomics Proteomics

View full text Add to dashboard Cite

Background: The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk. Materials and Methods: ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls. Results: The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed. Conclusion: The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan. According to the most recent report on cancer incidence and mortality by the International Agency for Research on Cancer, lung cancer has remained as the leading cause of cancer deaths all over the world (1). An estimated 2.1 million new lung cancer cases and 1.8 million cancer-related deaths occurred worldwide in 2018 (1). The rapidly increasing cases and the high death rate have urged us to look for effective marker(s) for the prediction of the risk of lung cancer, the outcome of the prognosis and the responsiveness of patient drug treatment. The initiation and development of lung cancer is related to multiple exogenous and endogenous factors including behavioral, environmental and genetic discrepancies, among which the consumption of cigarettes is the most significant factor to be associated with lung cancer risk (2). On the other hand, the fact that about 10% to 25% of lung cancer patients are non-smokers worldwide indicates that the individual genomic influences also play a critical part for personal lung cancer etiology (3). In Taiwan, the incidence and mortality of lung cancer has been ranked on the third and first place, respectively, among different types of cancer, for several years (4). Although several biomarkers for the early detection of lung cancer are being examined during recent years (5-11), the continuous search for effective clinically practical markers and the undermining mechanisms is still largely ongoing. Our genome is regularly and frequently damaged by various kinds of endogenous and exogenous mutagens and the DNA repair systems play a vital role in protecting it from irreversible mutations that can lead to carcinogenesis (12, 13). Concerning non-small cell lung cancer, genomic instability was 571 This article is freely accessible online.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Investigating the Frequency of the ERCC1 Gene C8092A Polymorphism in Iranian Patients with Advanced Gastric Cancer

Cited by 2 publications

References 24 publications

<p>Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review</p>

<p>Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review</p>

The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk

Contact Info

Product

Resources

About