Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions

Chetty, Lloyd C.; Kruger, Hendrik G.; Arvidsson, Per I.; Naicker, Tricia; Govender, Thavendran

doi:10.1039/d4ra00679h

RSC Adv.

2024

DOI: 10.1039/d4ra00679h

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Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions

Lloyd C. Chetty,

Hendrik G. Kruger,

Per I. Arvidsson

et al.

Abstract: The efficacy of green solvents and neat conditions in organocatalysed reactions were investigated. The results suggest cyclopentyl methyl ether and neat conditions could serve as alternatives, potentially enhancing the processes' sustainability.

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Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction

Díaz-Fernández,

Algarra,

Calvo-Losada

et al. 2024

Molecules

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The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.

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Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction

Díaz-Fernández,

Algarra,

Calvo-Losada

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions

Abstract: The efficacy of green solvents and neat conditions in organocatalysed reactions were investigated. The results suggest cyclopentyl methyl ether and neat conditions could serve as alternatives, potentially enhancing the processes' sustainability.

Cited by 1 publication

References 74 publications

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction

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