Investigating the effect of intra-articular PRP injection on pain and function improvement in patients with distal radius fracture

Namazi, Hamid; Mehbudi, A.

doi:10.1016/j.otsr.2015.11.002

Cited by 23 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In total 3160 articles were screened and 64 articles were found to be eligible for inclusion in the present review. Among these, 45 were pre-clinical in-vivo studies [1,2,4, and 19 were clinical studies [64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Platelet-rich plasma for the treatment of bone defects: from pre-clinical rational to evidence in the clinical practice. A systematic review

Roffi

Matteo

Krishnakumar

et al. 2016

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Platelet-rich plasma for the treatment of bone defects: from pre-clinical rational to evidence in the clinical practice. A systematic review

Roffi

Matteo

Krishnakumar

et al. 2016

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…VAS score and PRWE pain score were two common methods to evaluate pain degree and they were used in three trials [20,23,22]. VAS score was used to assess pain and numbness, and PRWE was applied to assess pain and function in patients with distal radius fracture [27,28]. …”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis

et al. 2016

View full text Add to dashboard Cite

PurposeNowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn’t come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing.MethodsWe searched PubMed, the Cochrane Library, and Embase in August 2016 for randomized controlled trials (RCTs) which concerned the treatment of teriparatide for fracture healing.ResultsFinally, a total of 380 patients were randomly assigned in the 5 trials included in this meta-analysis. There was a significant effectiveness with regards to function improvement in patients following fracture, however, there was no significant effectiveness with regards to time of radiographic fracture healing, fracture healing rate and reduction in pain.ConclusionsThis analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caution because of some clear limitations. If we want to confirm whether teriparatide improves fracture healing, more high-quality randomized controlled trials are needed.

show abstract

“…PRP is autologous and nontoxic, it is inherently safe, and any concerns of disease transmission or immunological reactions are eliminated. 6,[14][15][16][17] The increasing application of PRP in recent orthopedic surgeries presents significant opportunities as well as questions about the appropriate clinical use for this promising treatment. PRP has been used in a variety of orthopedic problems especially bone healing with variable degrees of successes and failures.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet-rich plasma (PRP), which is a concentration of platelets in a small volume of plasma, has gained widespread use to improve fracture union and function in a variety of clinical applications. [5][6][7] To date, the use of PRP has not been studied for its effects on scaphoid fracture.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Intra-articular Platelet-Rich Plasma Injection on Union: Pain and Function Improvement in Patients with Scaphoid Fracture

Namazi

Kayedi

2016

J Hand Microsurg

View full text Add to dashboard Cite

Introduction Fracture of the scaphoid bone is the most common fracture of the carpus. However, the fracture union occurs late or may not heal. Sometimes, fracture healing requires prolong immobilization. Because of potential for joint stiffness, muscle atrophy, or the inability to use the hand during and after prolonged immobilization, there is great incentive to develop therapies that will accelerate bone healing and allow a quick return to work. To date, the effect of platelet-rich plasma (PRP) on scaphoid fracture has not been studied. We aimed to assess the effect of intra-articular PRP injection on union: pain, range of motion, and function in patients with scaphoid fracture. Hypothesis Union: pain reduction and functional improvement can be noticed after PRP use in scaphoid fracture. Materials and Methods A randomized controlled trial was designed with 14 patients with scaphoid fractures (Herbert type B2). Casting was done for them. Seven patients received intra-articular autologous PRP. Patients were followed up 2 weeks after casting using radiography and then at 2 months using radiography and computed tomography (CT) scan to check bone healing. Then patients were followed up for 3 and 6 months and after evaluation of healing by CT scan, the patient-rated wrist evaluation questionnaire was completed and the range of motion of the wrist was measured. Results Analysis revealed significant improvement in pain at rest, as well as during specific and usual activities following PRP injection in the case group. However, no statistically significant difference in wrist motion including radial and ulnar deviation, flexion, and extension was found in 6 months follow-up except some improvement in ulnar deviation after 3 months. However, this study showed that scaphoid union occurred earlier in the case group, but it was not statistically significant. Conclusion PRP may have a significant effect on pain reduction at rest and amount of difficulty in functions including specific and usual activities in patients with scaphoid fractures. Level of Evidence This is a level III, therapeutic trial.

show abstract

Investigating the effect of intra-articular PRP injection on pain and function improvement in patients with distal radius fracture

Abstract: Level III, Therapeutic trial.

Cited by 23 publications

References 22 publications

Platelet-rich plasma for the treatment of bone defects: from pre-clinical rational to evidence in the clinical practice. A systematic review

Platelet-rich plasma for the treatment of bone defects: from pre-clinical rational to evidence in the clinical practice. A systematic review

Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis

Investigating the Effect of Intra-articular Platelet-Rich Plasma Injection on Union: Pain and Function Improvement in Patients with Scaphoid Fracture

Contact Info

Product

Resources

About