Investigating the effect of flow compensation and quantitative susceptibility mapping method on the accuracy of venous susceptibility measurement

Berg, Ronja; Preibisch, Christine; Thomas, David L.; Shmueli, Karin; Biondetti, Emma

doi:10.1016/j.neuroimage.2021.118399

Cited by 14 publications

(18 citation statements)

References 51 publications

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“…First, WM venous density is a less direct approach to quantitatively describe the susceptibility difference in the veins compared to quantitative susceptibility map (QSM), which would yield venous susceptibility value. However, reconstruction of venous susceptibility QSM has yet been standardized in clinical applications, which still requires optimization in the data processing pipeline for quantitative accuracy ( Berg et al, 2021 ). The major difficulty in using QSM is the partial volume effect of small veins which makes oxygen saturation quantification suspect.…”

Section: Discussionmentioning

confidence: 99%

Reduced white matter venous density on MRI is associated with neurodegeneration and cognitive impairment in the elderly

Rusinek

Chen

et al. 2022

Front. Aging Neurosci.

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High-resolution susceptibility weighted imaging (SWI) provides unique contrast to small venous vasculature. The conspicuity of these mesoscopic veins, such as deep medullary veins in white matter, is subject to change from SWI venography when venous oxygenation in these veins is altered due to oxygenated blood susceptibility changes. The changes of visualization in small veins shows potential to depict regional changes of oxygen utilization and/or vascular density changes in the aging brain. The goal of this study was to use WM venous density to quantify small vein visibility in WM and investigate its relationship with neurodegenerative features, white matter hyperintensities (WMHs), and cognitive/functional status in elderly subjects (N = 137). WM venous density was significantly associated with neurodegeneration characterized by brain atrophy (β = 0.046± 0.01, p < 0.001), but no significant association was found between WM venous density and WMHs lesion load (p = 0.3963). Further analysis of clinical features revealed a negative trend of WM venous density with the sum-of-boxes of Clinical Dementia Rating and a significant association with category fluency (1-min animal naming). These results suggest that WM venous density on SWI can be used as a sensitive marker to characterize cerebral oxygen metabolism and different stages of cognitive and functional status in neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Reduced white matter venous density on MRI is associated with neurodegeneration and cognitive impairment in the elderly

Rusinek

Chen

et al. 2022

Front. Aging Neurosci.

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“…Our control group (i.e., Australian footballers with a similar self-reported HoC but no recently diagnosed SRC in the past three months) is arguably the most clinically relevant in terms of assessing whether the proposed MRI biomarkers are sensitive to sub-acute SRC changes in this population; however future larger scale studies would benefit from also including control groups without a HoC and without a history of collision sport participation to provide insights into the impact of these variables. Susceptibility quantification can be confounded by partial volume effects on vessels from surrounding brain tissue, flow acceleration effects and the choice of QSM processing pipeline [ 32 ]. To best control for partial volume effects, we measured susceptibility over global gray and white matter segmentations based on a stability mask of reliable control values.…”

Section: Discussionmentioning

confidence: 99%

“…We also measured SvO 2 in the straight sinus, a large vessel approximately 5 mm in diameter [ 33 ], using maximum intensity projection images (MIPs). Furthermore, QSM images were reconstructed using nonlinear dipole inversion with Tikhonov regularization which has been shown to provide more accurate quantification of venous susceptibility than other methods [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Sub-acute Changes on MRI Measures of Cerebral Blood Flow and Venous Oxygen Saturation in Concussed Australian Rules Footballers

2022

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Background Sports-related concussion (SRC) is common in collision sport athletes. There is growing evidence that repetitive SRC can have serious neurological consequences, particularly when the repetitive injuries occur when the brain has yet to fully recover from the initial injury. Hence, there is a need to identify biomarkers that are capable of determining SRC recovery so that they can guide clinical decisions pertaining to return-to-play. Cerebral venous oxygen saturation (SvO2) and cerebral blood flow (CBF) can be measured using magnetic resonance imaging (MRI) and may provide insights into changing energy demands and recovery following SRC. Results In this study we therefore investigated SvO2 and CBF in a cohort of concussed amateur Australian Football athletes (i.e., Australia’s most participated collision sport). Male and female Australian footballers (n = 13) underwent MRI after being cleared to return to play following a mandatory 13-day recovery period and were compared to a group of control Australian footballers (n = 16) with no recent history of SRC (i.e., > 3 months since last SRC). Despite the concussed Australian footballers being cleared to return to play at the time of MRI, we found evidence of significantly increased susceptibility in the global white matter (p = 0.020) and a trend (F5,21 = 2.404, p = 0.071) for reduced relative CBF (relCBF) compared to the control group. Further, there was evidence of an interaction between sex and injury in straight sinus susceptibility values (F1,25 = 3.858, p = 0.061) which were decreased in female SRC athletes (p = 0.053). Of note, there were significant negative correlations between straight sinus susceptibility and relCBF suggesting impaired metabolic function after SRC. Conclusions These findings support the use of quantitative susceptibility mapping (QSM) and relCBF as sensitive indicators of SRC, and raise further concerns related to SRC guidelines that allow for return-to-play in less than two weeks.

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“…Despite the straight sinus being far away from the edge of the brain mask, the estimates of Y v in the straight sinus were even higher than in the SSS in our study. This may have been caused by partial volume effects in this venous structure, which is smaller than the SSS and more challenging to accurately segment, or could have been due to the use of L1 regularization in the χ map calculation which is known to underestimate venous χ ( Berg et al, 2021 ). The choice of susceptibility calculation method has been shown to have a significant effect on estimates of Y v, with Tikhonov-based regularization, as used in this study, shown to be the most accurate method for venous susceptibility measurement in a recent study ( Berg et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A Comparison of MRI Quantitative Susceptibility Mapping and TRUST-Based Measures of Brain Venous Oxygen Saturation in Sickle Cell Anaemia

et al. 2022

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In recent years, interest has grown in the potential for magnetic resonance imaging (MRI) measures of venous oxygen saturation (Yv) to improve neurological risk prediction. T2-relaxation-under-spin-tagging (TRUST) is an MRI technique which has revealed changes in Yv in patients with sickle cell anemia (SCA). However, prior studies comparing Yv in patients with SCA relative to healthy controls have reported opposing results depending on whether the calibration model, developed to convert blood T2 to Yv, is based on healthy human hemoglobin (HbA), bovine hemoglobin (HbBV) or sickle hemoglobin (HbS). MRI Quantitative Susceptibility Mapping (QSM) is an alternative technique that may hold promise for estimating Yv in SCA as blood magnetic susceptibility is linearly dependent upon Yv, and no significant difference has been found between the magnetic susceptibility of HbA and HbS. Therefore, the aim of this study was to compare estimates of Yv using QSM and TRUST with five published calibration models in healthy controls and patients with SCA. 17 patients with SCA and 13 healthy controls underwent MRI. Susceptibility maps were calculated from a multi-parametric mapping acquisition and Yv was calculated from the mean susceptibility in a region of interest in the superior sagittal sinus. TRUST estimates of T2, within a similar but much smaller region, were converted to Yv using five different calibration models. Correlation and Bland-Altman analyses were performed to compare estimates of Yv between TRUST and QSM methods. For each method, t-tests were also used to explore group-wise differences between patients with SCA and healthy controls. In healthy controls, significant correlations were observed between QSM and TRUST measures of Yv, while in SCA, there were no such correlations. The magnitude and direction of group-wise differences in Yv varied with method. The TRUST-HbBV and QSM methods suggested decreased Yv in SCA relative to healthy controls, while the TRUST-HbS (p < 0.01) and TRUST-HbA models suggested increased Yv in SCA as in previous studies. Further validation of all MRI measures of Yv, relative to ground truth measures such as O15 PET and jugular vein catheterization, is required in SCA before QSM or TRUST methods can be considered for neurological risk prediction.

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Investigating the effect of flow compensation and quantitative susceptibility mapping method on the accuracy of venous susceptibility measurement

Cited by 14 publications

References 51 publications

Reduced white matter venous density on MRI is associated with neurodegeneration and cognitive impairment in the elderly

Reduced white matter venous density on MRI is associated with neurodegeneration and cognitive impairment in the elderly

Sub-acute Changes on MRI Measures of Cerebral Blood Flow and Venous Oxygen Saturation in Concussed Australian Rules Footballers

A Comparison of MRI Quantitative Susceptibility Mapping and TRUST-Based Measures of Brain Venous Oxygen Saturation in Sickle Cell Anaemia

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