Investigating the correlation between the protein adhesion simulation and the biocompatibility of polymeric substrate for skin-tissue-engineering applications

Seifi, Saeed; Bakhtiari, Mohammad Ali; Shaygani, Hossein; Shamloo, Amir; Almasi-Jaf, Aram

doi:10.1039/d2cp05763h

Cited by 11 publications

(1 citation statement)

References 60 publications

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“…The development of new blood vessels not only ensures that the wound site receives an adequate amount of blood, nutrients, and oxygen but also speeds up the overall healing process and makes it easier for granulation tissue to form [173][174][175]. In the realm of skin tissue engineering, wound healing with the goal of boosting cellular proliferation and maintaining biosafety efficacy has seen the application of nanomaterials as a potential solution [176,177]. The ability to function as a protective barrier for regenerating keratinocytes is one of the desirable characteristics of biomaterials for this application.…”

Section: Skin Tissue Engineeringmentioning

confidence: 99%

Nanotechnology in tissue engineering: expanding possibilities with nanoparticles

Sardari,

Hheidari,

Ghodousi

et al. 2024

Nanotechnology

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Tissue engineering is a multidisciplinary field that merges engineering, material science, and medical biology in order to develop biological alternatives for repairing, replacing, maintaining, or boosting the functionality of tissues and organs. The ultimate goal of tissue engineering is to create biological alternatives for repairing, replacing, maintaining, or enhancing the functionality of tissues and organs. However, the current landscape of tissue engineering techniques presents several challenges, including a lack of suitable biomaterials, inadequate cell proliferation, limited methodologies for replicating desired physiological structures, and the unstable and insufficient production of growth factors, which are essential for facilitating cell communication and the appropriate cellular responses. Despite these challenges, there has been significant progress made in tissue engineering techniques in recent years. Nanoparticles hold a major role within the realm of nanotechnology due to their unique qualities that change with size. These particles, which provide potential solutions to the issues that are met in tissue engineering, have helped propel nanotechnology to its current state of prominence. Despite substantial breakthroughs in the utilization of nanoparticles over the past two decades, the full range of their potential in addressing the difficulties within tissue engineering remains largely untapped. This is due to the fact that these advancements have occurred in relatively isolated pockets. In the realm of tissue engineering, the purpose of this research is to conduct an in-depth investigation of the several ways in which various types of nanoparticles might be put to use. In addition to this, it sheds light on the challenges that need to be conquered in order to unlock the maximum potential of nanotechnology in this area.

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