Investigating the Contribution of NPSR1, IL-6 and BDNF Polymorphisms to Depressive and Anxiety Symptoms in Hemodialysis Patients

Alshogran, Osama Y.; AL-Eitan, Laith N.; Altawalbeh, Shoroq M.; Khalil, Amani A.; Alqudah, Mohammad; Oweis, Ashraf O; Aman, Hatem A; Alhawari, Hussein

doi:10.1016/j.pnpbp.2019.109657

Cited by 6 publications

(9 citation statements)

References 52 publications

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“…For example, a significant increase in anxiety symptom severity across psychiatric disorders was found in adult A-allele carrier Caucasian patients [ 85 ]. Increased frequency of the T allele was found in adult Caucasian hemodialysis patients with moderate or severe anxiety compared to those with low anxiety [ 86 ], whereas no significant differences in genotype distribution were observed in adult Chinese asthmatic patients with anxiety symptoms [ 87 ]. Similarly to the absence of changes in NPS level in patients with MDD, no significant differences in genotype distribution were observed in both hemodialysis and asthmatic patients with moderate or severe vs. low depression [ 86 , 87 ], thus confirming that the NPS/NPSR1 system is related to anxiety rather than depression.…”

Section: Alterations In the Nps/npsr1 System In Stress-related Disordersmentioning

confidence: 99%

“…Increased frequency of the T allele was found in adult Caucasian hemodialysis patients with moderate or severe anxiety compared to those with low anxiety [ 86 ], whereas no significant differences in genotype distribution were observed in adult Chinese asthmatic patients with anxiety symptoms [ 87 ]. Similarly to the absence of changes in NPS level in patients with MDD, no significant differences in genotype distribution were observed in both hemodialysis and asthmatic patients with moderate or severe vs. low depression [ 86 , 87 ], thus confirming that the NPS/NPSR1 system is related to anxiety rather than depression. It is important to mention, however, that a significant increased depression score was found in asthmatic patients carriers of both the AA genotype for the NPSR1 gene and the GG genotype for the BDNF gene [ 87 ], indicating a synergistic interaction between BDNF and NPSR1 polymorphisms on depression symptoms.…”

Section: Alterations In the Nps/npsr1 System In Stress-related Disordersmentioning

confidence: 99%

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Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Tobinski

Rappeneau

2021

Pharmaceuticals

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The neuropeptide S (NPS) and its receptor (NPSR1) have been extensively studied over the last two decades for their roles in locomotion, arousal/wakefulness and anxiety-related and fear-related behaviours in rodents. However, the possible implications of the NPS/NPSR1 system, especially those of the single nucleotide polymorphism (SNP) rs324981, in stress-related disorders and substance abuse in humans remain unclear. This is possibly due to the fact that preclinical and clinical research studies have remained separated, and a comprehensive description of the role of the NPS/NPSR1 system in stress-relevant and reward-relevant endpoints in humans and rodents is lacking. In this review, we describe the role of the NPS/NPSR1 system in emotionality, stress responsiveness and addiction-like behaviour in rodents. We also summarize the alterations in the NPS/NPSR1 system in individuals with stress-related disorders, as well as the impact of the SNP rs324981 on emotion, stress responses and neural activation in healthy individuals. Moreover, we discuss the therapeutic potential and possible caveats of targeting the NPS/NPSR1 system for the treatment of stress-related disorders. The primary goal of this review is to highlight the importance of studying some rodent behavioural readouts modulated by the NPS/NPSR1 system and relevant to stress-related disorders.

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Section: Alterations In the Nps/npsr1 System In Stress-related Disordersmentioning

confidence: 99%

Section: Alterations In the Nps/npsr1 System In Stress-related Disordersmentioning

confidence: 99%

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Tobinski

Rappeneau

2021

Pharmaceuticals

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“…These symptoms pose a threat to human health, as they are associated with adverse clinical outcomes such as increased hospitalization and mortality [2,3]. Multiple factors could be associated with vulnerability to psychiatric symptoms, including sociodemographic, clinical, and environmental elements, lifestyle, and the genetic background [4][5][6]. For instance, one study suggested 151 genes that could potentially be involved in major depressive disorder [7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…To date, only a small number of studies have examined the genetic contribution to psychiatric disease in HD patients [4,10]. For instance, it has been previously shown that the neuropeptide S receptor1 (NPSR1) Asn107Ile polymorphism was associated with anxiety in HD patients [4]. The dopamine receptor D4 (DRD4) gene 48 bp variable number of tandem repeats (VNTR) polymorphism at the third exon has been previously reported to be linked with mental illness or behavioral traits in different patient settings [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients

et al. 2021

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Mental illness is prevalent among hemodialysis (HD) patients. Given that the dopaminergic and serotonergic pathways are involved in the etiology of psychiatric disease, this study evaluated the genetic association of dopamine D4 receptor (DRD4) and serotonin transporter (SLC6A4) genes with psychiatric symptom susceptibility among HD patients. Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety and depressive symptoms among patients (n = 265). Genetic polymorphisms of DRD4 (48 bp VNTR) and SLC6A4 (5-HTTLPR VNTR and rs25531) were examined using a conventional polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, as appropriate. Significant differences were observed in the distribution of 5-HTTLPR genotypes, SLC6A4 tri-allelic-phased genotype, and DRD4-Exon III VNTR genotypes/alleles between patients with anxiety symptoms versus those with normal/borderline conditions (p<0.05). Binary logistic regression analyses showed that the heterozygous 4,5 VNTR genotype of DRD4 was associated with a higher risk of anxiety symptoms after adjusting for other covariates (odds ratio = 4.25, p = 0.028). None of the studied polymorphisms was linked to depression in HD patients. Collectively, the current findings provide genetic clues to psychopathology in HD patients and suggest that the DRD4 exon III VNTR polymorphism is involved in the etiology of anxiety in this patient population.

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Comparison of two self-report scales to assess anxiety and depressive symptoms in hemodialysis patients

Alshogran¹,

Altawalbeh²,

Khalil³

2022

Archives of Psychiatric Nursing

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Investigating the Contribution of NPSR1, IL-6 and BDNF Polymorphisms to Depressive and Anxiety Symptoms in Hemodialysis Patients

Cited by 6 publications

References 52 publications

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders

Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients

Comparison of two self-report scales to assess anxiety and depressive symptoms in hemodialysis patients

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