Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan

Huang, Cheng; Hsiao, Jenn Ren; Lee, Wei Ting; Lee, Yao Chou; Ou, Chien-Hui; Chang, Chan-Chi; Lü, Yu; Huang, Jow-Lay; Wong, Tung Yiu; Chen, Ken Chung; Tsai, Sen Tien; Fang, Sheen Yie; Wu, Jiunn-Lin; Wu, Yuan; Hsueh, Wei; Yen, Chia Jui; Wu, Shang Yin; Chang, Jang Yang; Lin, Chen Lin; Wang, Yi Hui; Weng, Ya Ling; Chen, Yu Shan; Chang, Jeffrey S.

doi:10.1038/s41598-017-08802-4

Cited by 32 publications

(28 citation statements)

References 38 publications

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“…Moreover, the ADH1B Ã 1 allele increased the risk of MPT occurrence in the esophagus and upper digestive tract (Table 4). The protective effect of the ADH1B Ã 2 allele is consistent with the results of several previous studies in HNC and esophageal cancer (28,33). Two possible explanations for this consistency are suggested (32): First, the fast initial metabolism may lead to a peak in acetaldehyde exposure, inducing alternative mechanisms to reduce this peak.…”

Section: Discussionsupporting

confidence: 89%

Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers

Chien

Young

Chen

et al. 2019

Cancer Prevention Research

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Multiple primary tumors (MPT), especially in the hypopharynx and esophagus, are challenging in patients with head and neck cancer (HNC). Alcohol and alcohol-metabolizing genes were reported to be related to upper digestive tract cancers. Here, we investigated whether the genotypes of alcoholmetabolizing enzymes (ADH1B, ADH1C, and ALDH2) affected patients' susceptibility to developing MPTs. We recruited 659 male patients with HNC between March 1996 and February 2017. Age-and gender-matched controls were also recruited. A total of 164 patients with HNC were identified to have second or third malignancies. The single-nucleotide polymorphisms in ADH1B (rs1229984), ADH1C (rs698), and ALDH2 (rs671) were analyzed by Taq-Man assays. The prevalence of ALDH2 Ã 2 allele carriers is significantly higher than that of Ã 1 Ã 1 homo-zygotes for oral cavity (P ¼ 0.013) and oropharyngeal cancers (P ¼ 0.012). For ADH1B, the number of Ã 1 allele carriers is significantly higher than that of Ã 2 Ã 2 homozygotes for oropharyngeal (P ¼ 0.017) and hypopharyngeal cancers (P < 0.001). ADH1C (rs698) SNPs are not significantly associated with tumor subsites (all P > 0.05). Polymorphisms in ALDH2 (Ã 2 allele carriers) and ADH1B (Ã 1 allele carriers) significantly increase the risk of developing MPTs in the upper digestive tract [P < 0.001, OR (95% confidence interval (CI): 5.186 (2.444-11.004) and P < 0.05, OR (95% CI): 2.093 (1.149-3.812), respectively]. ALDH2 (rs671) Ã 2 and ADH1B (rs1229984) Ã 1 allele carriers were shown to develop MPTs in the upper digestive tract. Genetic information may be used to identify high-risk patients for the development of MPTs.

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Section: Discussionsupporting

confidence: 89%

Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers

Chien

Young

Chen

et al. 2019

Cancer Prevention Research

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“…Certainly, this may lead to depression, decreased self‐esteem, and suicidal ideation . Second, these 3 malignancies are all associated with cigarette smoking, which is an independent risk factor for suicide; in addition, alcohol is a risk factor for head and neck cancer and suicide . Third, these malignancies are generally associated with advanced‐stage disease that has poor survival, thus placing these patients at increased risk of suicidal death as we and others have shown.…”

Section: Discussionmentioning

confidence: 94%

Cancer diagnosis and risk of suicide after accounting for prediagnosis psychiatric care: A matched‐cohort study of patients with incident solid‐organ malignancies

Klaassen

Wallis

Chandrasekar

et al. 2019

Cancer

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Background Previous studies have demonstrated an association between a diagnosis of cancer and the risk of suicide; however, they failed to account for psychiatric care before a cancer diagnosis, which may confound this relationship. The objective of this study was to assess the effect of a cancer diagnosis on the risk of suicide, accounting for prediagnosis psychiatric care utilization. Methods All adult residents of Ontario, Canada who were diagnosed with cancer (1 of prostate, breast, colorectal, melanoma, lung, bladder, endometrial, thyroid, kidney, or oral cancer) between 1997 and 2014 were identified. Noncancer controls were matched 4:1 based on sociodemographics, including a psychiatric utilization gradient (PUG) score (with 0 indicating none; 1, outpatient; 2, emergency department; and 3, hospital admission). A marginal, cause‐specific hazard model was used to assess the effect of cancer on the risk of suicidal death. Results Among 676,470 patients with cancer and 2,152,682 matched noncancer controls, there were 8.2 and 11.4 suicides per 1000 person‐years of follow‐up, respectively. Patients with cancer had an overall higher risk of suicidal death compared with matched patients without cancer (hazard ratio, 1.34; 95% CI, 1.22‐1.48). This effect was pronounced in the first 50 months after cancer diagnosis (hazard ratio, 1.60; 95% CI, 1.42‐1.81); patients with cancer did not demonstrate an increased risk thereafter. Among individuals with a PUG score 0 or 1, those with cancer were significantly more likely to die of suicide compared with controls. There was no difference in suicide risk between patients with cancer and controls for those who had a PUG score of 2 or 3. Conclusions A cancer diagnosis is associated with increased risk of death from suicide compared with the general population even after accounting for precancer diagnosis psychiatric care utilization. The specific factors underlying the observed associations remain to be elucidated.

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“…In another study of 811 HNC patients and 940 controls from Taiwan, alcohol was associated with increased risk for HNC, with the highest risk for hypopharyngeal cancer (89.1%) and oropharyngeal (55.7%) cancers. Alcohol explained 47.3% of HNCs in individuals with a genotype combination of slow ADH1B and slow/nonfunctional ALDH2 . In a study in Japan, the presence of ADH2 Arg/Arg and ALDH2 Glu/Lys were independently associated with increased risk of HNC, odds ratios of 2.67 and 1.66, respectively.…”

Section: Introductionmentioning

confidence: 99%

Alcohol‐related head and neck cancer: Summary of the literature

2019

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Alcohol drinking is a risk factor for the development of head‐and‐neck malignancies, including oral, pharyngeal, and laryngeal cancers, and coupled with tobacco use, accounts for 75% of oral cancers. We summarized the literature on alcohol‐related head and neck cancer (HNC) and identified gaps that represent areas for future investigation. Research indicates that alcohol consumption has not only been linked to the development of primary HNCs, but also to secondary cancers with continued alcohol intake, cancer recurrences, and other poor health outcomes. Given this evidence, several organizations have called for reduction or avoidance of alcohol, particularly in HNC survivors. Despite these strong recommendations, evidence suggests that HNC survivors continue to use alcohol. There is a need to forge collaborations among clinicians, researchers, and social workers, to address this problem of alcohol consumption in the growing population of HNC survivors.

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Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan

Cited by 32 publications

References 38 publications

Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers

Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers

Cancer diagnosis and risk of suicide after accounting for prediagnosis psychiatric care: A matched‐cohort study of patients with incident solid‐organ malignancies

Alcohol‐related head and neck cancer: Summary of the literature

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