INVESTIGATING THE ALLELIC VARIATION OF LOCI CONTROLLING RUST RESISTANCE GENES IN WHEAT (Triticum aestivum L.) LAND RACES BY SSR MARKER

Khattak, Sahir Hameed; Begum, Shameem Ara; Aqeel, Muhammad; Fayyaz, Muhammad; Bangash, Sajid Ali Khan; Riaz, Muhammad Naeem; Saeed, Shagufta; Ahmed, Ashour M.; Ali, Gowhar

doi:10.15666/aeer/1806_80918118

Cited by 8 publications

(16 citation statements)

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“…For curing lethal diseases with huge global impact, long-term effective technique with fewer (or less intense) side-effects will be required with a combined methodology instead of a short-range approach and a targeted way out instead of conventional agriculture approaches for example nanotechnology [ 2 , 45 ]. Therefore, in the present study, plant extract in the green synthesis of nanoparticles was investigated with cell lines and also their use against diabetes [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Various strategies, including dietary management, exercise-based therapies, novel drug development, homeopathic and herbal medicines, pharmacotherapy, nanotechnology, traditional medicines, and combined anti-diabetic or ‘anti-hyperglycemic’ therapies are prioritized as various methods for treatment and prevention of DM2 globally [ 1 ]. In recent years, various target-oriented scientific approaches have been devised to overcome the loss inflicted by lethal diseases of plants and animals [ 2 ]. Among them, nanotherapeutics have proven to have tremendous potential to combat chronic/fatal diseases as they enhance the overall impact of drugs on biological systems by increasing absorption of drug, improving drug solubility, extending drug half-life, raising a drug’s therapeutic index, and reducing the immunogenicity of a drug [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, various target-oriented scientific approaches have been devised to overcome the loss inflicted by lethal diseases of plants and animals [ 2 ]. Among them, nanotherapeutics have proven to have tremendous potential to combat chronic/fatal diseases as they enhance the overall impact of drugs on biological systems by increasing absorption of drug, improving drug solubility, extending drug half-life, raising a drug’s therapeutic index, and reducing the immunogenicity of a drug [ 2 ]. Nanotherapeutics encompasses the development, distribution, monitoring, and control of drugs in terms of repair, defense, and improvement of human biological systems at the molecular level.…”

Section: Introductionmentioning

confidence: 99%

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Biogenic Synthesis of Silver Nanoparticles Using Catharanthus roseus and Its Cytotoxicity Effect on Vero Cell Lines

Jamil¹,

Khattak²,

Farrukh

et al. 2022

Molecules

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Background: Type 2 diabetes mellitus (DM2) is a chronic and sometimes fatal condition which affects people all over the world. Nanotherapeutics have shown tremendous potential to combat chronic diseases—including DM2—as they enhance the overall impact of drugs on biological systems. Greenly synthesized silver nanoparticles (AgNPs) from Catharanthus roseus methanolic extract (C. AgNPs) were examined primarily for their cytotoxic and antidiabetic effects. Methods: Characterization of C. AgNPs was performed by UV–vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and atomic force microscopy (AFM). The C. AgNPs were trialed on Vero cell line and afterwards on an animal model (rats). Results: The C. AgNPs showed standard structural and functional characterization as revealed by FTIR and XRD analyses. The zetapotential analysis indicated stability while EDX analysis confirmed the formation of composite capping with Ag metal. The cytotoxic effect (IC50) of C. AgNPs on Vero cell lines was found to be 568 g/mL. The animal model analyses further revealed a significant difference in water intake, food intake, body weight, urine volume, and urine sugar of tested rats after treatment with aqueous extract of C. AgNPs. Moreover, five groups of rats including control and diabetic groups (NC1, PC2, DG1, DG2, and DG3) were investigated for their blood glucose and glycemic control analysis. Conclusions: The C. AgNPs exhibited positive potential on the Vero cell line as well as on experimental rats. The lipid profile in all the diabetic groups (DG1-3) were significantly increased compared with both of the control groups (p < 0.05). The present study revealed the significance of C. AgNPs in nanotherapeutics.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biogenic Synthesis of Silver Nanoparticles Using Catharanthus roseus and Its Cytotoxicity Effect on Vero Cell Lines

Jamil¹,

Khattak²,

Farrukh

et al. 2022

Molecules

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“…The discovery of new methods and technology has helped humanity in many ways [ 88 , 89 , 90 , 91 ], and one of the common examples is the KD, which has been successfully used to manage seizures [ 92 ]. The employment of KD for treating neurological disorders, such as epileptic seizures is increasing worldwide.…”

Section: Importance Of Kdmentioning

confidence: 99%

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

et al. 2022

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Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.

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“…Long-term effective methods with fewer side effects will be needed using a combination methodology (such as marker technology, gene/protein sequencing, docking studies and specially nanotechnology), rather than a short-range approach and a focused conventional strategy/approach [17][18][19]. In this aspect, the developed "Nanotechnology-based" combination therapy decreases toxicity that is linked to a specific drug and suppresses multi-drug resistance because of different mechanisms of action [20,21].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant Escherichia coli and Pseudomonas aeruginosa

Yu,

Alkasir,

Farrukh

et al. 2024

Pol. J. Environ. Stud.

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Nanotechnology offers exciting prospects against infectious agents, particularly multidrug resistance bacteria (MDR), which is the roaring concern of this era. Zinc oxide nanoparticles (ZnO-Nps) efficiently deliver therapeutic agents into living systems due to their biocompatibility and bioactivity, which make them highly effective against infectious pathogens. The present investigation was designed to investigate the impact of the ZnO-Nps in combination with the Piperacillin-Tazobactam (TZP) drug against MDR. TZP are beta-lactam antibiotics highly effective against Gram-positive and Gram-negative

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INVESTIGATING THE ALLELIC VARIATION OF LOCI CONTROLLING RUST RESISTANCE GENES IN WHEAT (Triticum aestivum L.) LAND RACES BY SSR MARKER

Cited by 8 publications

References 0 publications

Biogenic Synthesis of Silver Nanoparticles Using Catharanthus roseus and Its Cytotoxicity Effect on Vero Cell Lines

Biogenic Synthesis of Silver Nanoparticles Using Catharanthus roseus and Its Cytotoxicity Effect on Vero Cell Lines

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant Escherichia coli and Pseudomonas aeruginosa

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