Investigating the ability of nanoparticle-loaded hydroxypropyl methylcellulose and xanthan gum gels to enhance drug penetration into the skin

Cai, Xiulian Jesmine; Mesquida, Patrick; Jones, Stuart A.

doi:10.1016/j.ijpharm.2016.08.055

Cited by 20 publications

(8 citation statements)

References 37 publications

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“…[6][7][8][9][10] The relative advantageous properties of the two components were partially combined in such blends, which presented quite good processibility, mechanical properties, and barrier properties to oxygen and water vapor. [3,4,6,9,10] Other cooling gels [11][12][13][14] have also been blended with the thermal gel HPMC for different purposes.…”

Section: Introductionmentioning

confidence: 99%

Effect of annealing on morphologies and performances of hydroxypropyl methylcellulose/hydroxypropyl starch blends

Chen

Liao

Liu

et al. 2020

J of Applied Polymer Sci

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The morphologies and performances of the blends of hydroxypropyl methylcellulose (HPMC), which is a thermal gel, and hydroxypropyl starch (HPS), which is a cooling gel, provides a scientific model to understand the relationship between the microstructure and performance of the unique thermal/cooling gel system. The films based on these blends have been developed for various applications, such as food packaging and medicine capsules, mainly for improving processibility. The morphologies and performance of the blends strongly depend on annealing or storage conditions and time since they are neither miscible nor compatible. This work focuses on the effects of storage conditions and time on the morphologies and performance of the blend films. It was found that the morphologies of the blend system depend on temperature, moisture, and annealing time. Correspondently, the gas permeability and mechanical properties of the film were also environmentally and time dependent. When HPS is continuous phase, the annealing results in starch recrystallization, which increases rigidity. When HPMC is the continuous phase, the materials showed less moisture sensitivity. Starch recrystallization and phase separation, which resulted in microcracks on the surface of the films, are the main reasons for the reduction in gas barrier and elongation. This work will study these issues using scanning electron microscope, X‐ray diffraction, mechanical testing and establish their relationship.

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Section: Introductionmentioning

confidence: 99%

Effect of annealing on morphologies and performances of hydroxypropyl methylcellulose/hydroxypropyl starch blends

Chen

Liao

Liu

et al. 2020

J of Applied Polymer Sci

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“…HPMC was selected as a gelling agent because of its ability to produce gel with larger pore size with minimal diffusional restriction for the TBH. 17 , 18 Accurately weighed amount of HPMC was add into water and stirred for 60 min at 1000 r/min. Gel pH was adjusted to 5.5 with tri-ethanol-amine (TEA).…”

Section: Methodsmentioning

confidence: 99%

Development and Evaluation of pH-Responsive Pluronic F 127 Co-Poly- (Acrylic Acid) Biodegradable Nanogels for Topical Delivery of Terbinafine HCL

et al. 2022

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Research aimed to develop and evaluate biodegradable, pH-responsive chemically cross-linked Pluronic F127 co-poly- (acrylic acid) nanogels for dermal delivery of Terbinafine HCL (TBH) to increase its permeability and as a new approach to treat skin fungal infections. TBH-loaded nanogels were successfully synthesized from acrylic acid (AA) and Pluronic F127 by free-radical copolymerization technique using N,N′-methylene bisacrylamide (MBA) as crosslinker and ammonium persulphate (APS) as initiator. Prepared nanogels exhibited 93.51% drug entrapment efficiency (DEE), 45 nm particle size, pH-dependent swelling and release behavior. Nanogels were characterized using different physicochemical techniques. The ex-vivo skin retention studies through rat skin showed about 42.34% drug retention from nanogels while 1% Lamisil cream (marketed product) showed about 26.56% drug retention. Moreover, skin irritation studies showed that nanogels were not irritating. Nanogels showed improved in-vitro antifungal activity against Candida albicans compared to commercial product. In-vivo studies on rats infected with Candida albicans confirmed superiority of nanogels over 1% Lamisil for eradication of fungal infection. This confirms that TBH loaded in Pluronic F127 co-poly-(acrylic acid) nanogels provided greater targetibility and cure rates of poorly soluble TBH in animal model and hence nanogels could be a potential carrier for effective topical delivery of TBH for skin fungal infection treatment.

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“…The vast majority of its chemical composition is comprised of two distinct units, namely -L-guluronic acid and -D-mannuronic acid, which are connected to one another by a 1.4-glycosidic bond. 88 The advantages associated with alginate-based NH are their biocompatibility, porosity and water retention capabilities, viscosity, and ability to undergo ionic gel formation. 25 , 89 The challenges associated with Alginate-Based Nanohydrogel are closely related to the process of ionic crosslinking and degradation, which has garnered significant attention within the scientific community.…”

Section: Polymeric Topical Nhmentioning

confidence: 99%

Polymeric Nanohydrogel in Topical Drug Delivery System

Yuniarsih,

Chaerunisaa,

Elamin

et al. 2024

IJN

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Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on their pertinent contemporary treatments, this review aims to give a complete overview of recent advances in the creation and application of polymer NH in biomedicine. We will explore the key features that have driven advances in nanotechnology and discuss the significance of nanohydrogel-based formulations as vehicles for delivering therapeutic agents topically. The review will also cover the latest findings and references from the literature to support the advancements in nanotechnological technology related to the preparation and application of NH. In addition, we will also discuss the unique properties and potential applications of NH as drug delivery systems (DDS) for skin applications, underscoring their potential for effective topical therapeutic delivery. The challenge lies in efficiently delivering drugs through the skin’s barrier to specific areas with high control. Environmentally sensitive systems, like polymer-based NH, show promise in treating dermatological conditions. Polymers are pivotal in developing these drug delivery systems, with NH offering advantages such as versatile drug loading, controlled release, and enhanced skin penetration.

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Investigating the ability of nanoparticle-loaded hydroxypropyl methylcellulose and xanthan gum gels to enhance drug penetration into the skin

Cited by 20 publications

References 37 publications

Effect of annealing on morphologies and performances of hydroxypropyl methylcellulose/hydroxypropyl starch blends

Effect of annealing on morphologies and performances of hydroxypropyl methylcellulose/hydroxypropyl starch blends

Development and Evaluation of pH-Responsive Pluronic F 127 Co-Poly- (Acrylic Acid) Biodegradable Nanogels for Topical Delivery of Terbinafine HCL

Polymeric Nanohydrogel in Topical Drug Delivery System

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