Investigating severe and fatal asthma

Call, Robert S.; Ward, George W.; Jackson, Sandra; Platts-Mills, Thomas A.E.

doi:10.1016/0091-6749(94)90125-2

Cited by 30 publications

(12 citation statements)

References 32 publications

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“…Sensitization and seasonal exposure to Alternaria has been proposed as a risk factor for sudden death from asthma. The degree of exposure of the people with severe brittle asthma to relevant aeroallergens in their home is not known, but this may be relevant to some rapid episodes of deterioration (47).…”

Section: Allergen and Occupational Exposurementioning

confidence: 99%

Difficult asthma

Garcia

and

Humbert

2003

Allergy

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Section: Allergen and Occupational Exposurementioning

confidence: 99%

Difficult asthma

Garcia

and

Humbert

2003

Allergy

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“…Indeed, the association between trigger and inflammation,6,7 inflammation and bronchial hyper-reactivity,8–12 and airway obstruction and symptoms is not always strong. Asthma phenotypes are very heterogeneous—eg, inflammation can be predominantly eosinophilic, neutrophilic, or involve other pathways 13–19.…”

Section: Introductionmentioning

confidence: 99%

Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment, and disease progression and control

Frey¹,

Suki²

2008

The Lancet

131

123

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Although assessment of asthma control is important to guide treatment, it is difficult since the temporal pattern and risk of exacerbations are often unpredictable. In this Review, we summarise the classic methods to assess control with unidimensional and multidimensional approaches. Next, we show how ideas from the science of complexity can explain the seemingly unpredictable nature of bronchial asthma and emphysema, with implications for chronic obstructive pulmonary disease. We show that fluctuation analysis, a method used in statistical physics, can be used to gain insight into asthma as a dynamic disease of the respiratory system, viewed as a set of interacting subsystems (eg, inflammatory, immunological, and mechanical). The basis of the fluctuation analysis methods is the quantification of the long-term temporal history of lung function parameters. We summarise how this analysis can be used to assess the risk of future asthma episodes, with implications for asthma severity and control both in children and adults.

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“…Reversal of bronchial hyperresponsiveness, with a reduction in oral steroid requirement during prolonged hospitalization in an environment with a low level of house dust mites, has been reported in mild‐to‐moderately‐severe asthmatics [65]. Sensitization and seasonal exposure to Alternaria has been proposed as a risk factor for sudden death caused by asthma [66]. The degree of exposure of patients with severe brittle asthma to relevant aeroallergens in their homes is not known, but may be relevant to the rapid onset of episodes of deterioration in these patients.…”

Section: Management and Treatmentmentioning

confidence: 99%