Investigating phenotypic plasticity due to toxicants with exposure disparities in primary human breast cells in vitro
Jade Schroeder,
Katelyn M. Polemi,
Anagha Tapaswi
et al.
Abstract:IntroductionBreast cancer is the second most diagnosed cancer, as well as the primary cause of cancer death in women worldwide. Of the different breast cancer subtypes, triple-negative breast cancer (TNBC) is particularly aggressive and is associated with poor prognosis. Black women are two to three times more likely to be diagnosed with TNBCs than white women. Recent experimental evidence suggests that basal-like TNBCs may derive from luminal cells which acquire basal characteristics through phenotypic plasti… Show more
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