Investigating Neurogenesis in Birds

Rodrigues, Tania; Brodier, Laurent; Matter, Jean‐Marc

doi:10.1007/978-1-0716-0175-4_1

Cited by 1 publication

(1 citation statement)

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“…Chicken have long been regarded as an ideal model for virology, physiological and behavioral traits, immunology, biotechnology and developmental biology [34][35][36][37][38]. In light of the importance of the chicken to human societies around the world, genetic diversity and gene regulatory of the chicken (Gallus gallus) is of great interest [39]. Since that vast majority of biological processes, from development to homeostasis maintenance, from cell cycle to cell differentiation, are tuned by differential gene expression [40], understanding expression patterns of TFs is fundamental important in early embryo development.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis reveals the dynamic changes of transcription factors during early development of chicken embryo

et al. 2022

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Background The transition from fertilized egg to embryo in chicken requires activation of hundreds of genes that were mostly inactivated before fertilization, which is accompanied with various biological processes. Undoubtedly, transcription factors (TFs) play important roles in regulating the changes in gene expression pattern observed at early development. However, the contribution of TFs during early embryo development of chicken still remains largely unknown that need to be investigated. Therefore, an understanding of the development of vertebrates would be greatly facilitated by study of the dynamic changes in transcription factors during early chicken embryo. Results In the current study, we selected five early developmental stages in White Leghorn chicken, gallus gallus, for transcriptome analysis, cover 17,478 genes with about 807 million clean reads of RNA-sequencing. We have compared global gene expression patterns of consecutive stages and noted the differences. Comparative analysis of differentially expressed TFs (FDR < 0.05) profiles between neighboring developmental timepoints revealed significantly enriched biological categories associated with differentiation, development and morphogenesis. We also found that Zf-C2H2, Homeobox and bHLH were three dominant transcription factor families that appeared in early embryogenesis. More importantly, a TFs co-expression network was constructed and 16 critical TFs were identified. Conclusion Our findings provide a comprehensive regulatory framework of TFs in chicken early embryo, revealing new insights into alterations of chicken embryonic TF expression and broadening better understanding of TF function in chicken embryogenesis.

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