Investigating Molecular Mechanisms Underlying the Therapeutic Effects of Zuo Jin Pill in Ulcerative Colitis: A Combined Approach of Network Pharmacology and Experimental Validation
Xiao Xiao,
Lihong Wu,
Chuanyu Zhan
et al.
Abstract:Objective: The Zuo Jin pill (ZJP), a classic formula for treating gastrointestinal diseases, has demonstrated good efficacy in the treatment of ulcerative colitis (UC). In this study, we aimed to elucidate the mechanism of action of ZJP in UC through network pharmacology and experimental validation. Methods: Bioactive compounds and targets of ZJP, along with UC-related targets, were retrieved from public databases. The intersecting targets of ZJP and UC were visualized using a Venn diagram. Protein–protein int… Show more
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