Investigating men’s motivations to engage in genetic screening for BRCA1 and BRCA2 mutations

Annoni, Anna Maria; Longhini, Claudia

doi:10.1371/journal.pone.0265387

Cited by 5 publications

(2 citation statements)

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“…The character of available information on BRCA1/2-related cancers is directed mainly at women, reflecting a gendered approach that may lead men to underestimate their risk of carrying BRCA mutations [25]. The determinants of men's motivations to engage in genetic screening for BRCA1 and BRCA2 were explored in a very recent study by Annoni and Longhini [26] through the lens of the Health Action Process Approach. One-hundred and twenty-five men with a mean age of 58.53 ± 10.37 participated in an online survey.…”

Section: Importance Of Genetic Screening Of Men With Brcamentioning

confidence: 99%

BRCA Gene Mutations and Prostate Cancer

Kharaishvili¹,

Kacheishvili²,

Akhvlediani³

2023

BRCA1 and BRCA2 Mutations - Diagnostic and Therapeutic Implications

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Prostate cancer remains the second most common cancer in men, with diverse courses from indolent cases to aggressive diseases. Among the key factors implicated in its pathogenesis are genomic alterations such as the TMPRSS2-ERG and related fusion oncogenes, loss of tumor suppressor PTEN, p53 or NKX3.1, inflammation, enhanced DNA damage, and chromosomal instability. Men with prostate cancer who carry BRCA1/2 mutations are at more risk of worse disease and poor prognosis. Cancer cells with mutant BRCA1 or BRCA2 repair genes with defects in homologous recombination are vulnerable to PARP inhibitors that target the genetic phenomenon known as synthetic lethality to exploit faulty DNA repair mechanisms. With relevance to prostate cancer, other features of cancer cells may also sensitize to PARP inhibitors, including aberrant transcription due to the androgen-driven fusion oncogene TMPRSS2-ERG or PTEN loss. Several models of synthetic lethality and potential biomarkers suggested up to date are also discussed. The chapter also highlights the importance of genetic screening of men with BRCA and shows diagnostic utility of plasma-derived circulating tumor DNA.

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Section: Importance Of Genetic Screening Of Men With Brcamentioning

confidence: 99%

BRCA Gene Mutations and Prostate Cancer

Kharaishvili¹,

Kacheishvili²,

Akhvlediani³

2023

BRCA1 and BRCA2 Mutations - Diagnostic and Therapeutic Implications

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“…There is support for the use of the HAPA model in explaining the initiation and maintenance of health preventive behaviors in several health contexts [30][31][32][33] including cancer-related screening behavior [34,35]. To the best of our knowledge, no studies have quantitatively and systematically tested which psychological determinants are involved in men's decision-making processes for predictive BRCA1/2 genetic testing in cascade screening context.…”

Section: Introductionmentioning

confidence: 99%

Psychological Determinants of Men’s Adherence to Cascade Screening for BRCA1/2

et al. 2022

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BRCA1/2 germline mutations predispose carriers to an increased risk of breast, ovarian, prostate, pancreatic, and skin cancer. Men and women are equally likely to pass on or inherit the pathogenic variant. However, there is evidence that male relatives are less involved in cascade screening than female ones. At the same time, little attention has been given to the research on psychological determinants of men’s adherence to cascade screening in BRCA1/2-positive families. Applying some principles of the Health Action Process Approach model, the present research tested a model of relationships on the adherence to BRCA1/2 cascade testing guidelines. The sample comprised 115 men’s first-degree relatives of women with verified germline mutations (Mage = 41.93; SD = 17.27). A pre–post test design was applied. Significant associations emerged between the intention to uptake BRCA1/2 genetic testing and age, parental status, breast cancer risk perception, self-referred outcome expectancies, perceived benefit, coping self-efficacy, and planning. Higher perceived benefit predicted increases in intention, and higher intention and coping self-efficacy predicted increases in planning. Intention was a positive total mediator of the relationship between benefit and planning. On a theoretical level, our findings partially supported the Health Action Process Approach as a valuable model based on which interventions could be developed in the context of cascade screening for BRCA1/2 genetic testing. Those results supported the importance of integrated genetic counselling sessions with a strict collaboration between geneticists and psychologists together with interventions planned to increase men’s self-monitoring ability to support their self-efficacy.

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