Investigating Memory Updating in Mice Using the Objects in Updated Locations Task

Wright, Destiny S.; Bodinayake, Kasuni K.; Kwapis, Janine L.

doi:10.1002/cpns.87

Cited by 13 publications

(16 citation statements)

References 29 publications

(52 reference statements)

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“…Finally, a test session (retrieval) where animals discriminate and identify a novel object in the case of NOR or the displaced one in the case of OLRM (Ameen-Ali et al, 2015 ; Chan et al, 2018 ). In addition, novel information can be integrated during retrieval and updating recognition memory (Balderas et al, 2015 ; Kwapis et al, 2020 ; Wright et al, 2020 ; see Figure 1 ). These tasks allow us to assess the ability of animals to recognize environmental changes caused by exposure to a novel object or a novel spatial configuration and help determine novel/familiar discrimination and recollection processes.…”

Section: Spontaneous Object Explorationmentioning

confidence: 99%

Dopamine activity on the perceptual salience for recognition memory

Osorio-Gómez

Guzmán-Ramos

Bermúdez‐Rattoni

2022

Front. Behav. Neurosci.

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To survive, animals must recognize relevant stimuli and distinguish them from inconspicuous information. Usually, the properties of the stimuli, such as intensity, duration, frequency, and novelty, among others, determine the salience of the stimulus. However, previously learned experiences also facilitate the perception and processing of information to establish their salience. Here, we propose “perceptual salience” to define how memory mediates the integration of inconspicuous stimuli into a relevant memory trace without apparently altering the recognition of the physical attributes or valence, enabling the detection of stimuli changes in future encounters. The sense of familiarity is essential for successful recognition memory; in general, familiarization allows the transition of labeling a stimulus from the novel (salient) to the familiar (non-salient). The novel object recognition (NOR) and object location recognition (OLRM) memory paradigms represent experimental models of recognition memory that allow us to study the neurobiological mechanisms involved in episodic memory. The catecholaminergic system has been of vital interest due to its role in several aspects of recognition memory. This review will discuss the evidence that indicates changes in dopaminergic activity during exposure to novel objects or places, promoting the consolidation and persistence of memory. We will discuss the relationship between dopaminergic activity and perceptual salience of stimuli enabling learning and consolidation processes necessary for the novel-familiar transition. Finally, we will describe the effect of dopaminergic deregulation observed in some pathologies and its impact on recognition memory.

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Section: Spontaneous Object Explorationmentioning

confidence: 99%

Dopamine activity on the perceptual salience for recognition memory

Osorio-Gómez

Guzmán-Ramos

Bermúdez‐Rattoni

2022

Front. Behav. Neurosci.

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“…We have recently developed a new reconsolidation-dependent memory updating paradigm called the objects in updated locations task, or OUL, that is based on the spatial object location memory task [2,41]. In OUL, the animal is first exposed to two copies of an identical object in specific locations in the training arena (A 1 and A 2 ), creating the original memory.…”

Section: Objects In Updated Locationsmentioning

confidence: 99%

“…As mice prefer novelty, a mouse that remembers the original and updated object locations should preferentially explore the object in the novel location (A 4 ) at test. Thus, by comparing exploration of the novel location to exploration of the other three locations, the researcher can infer whether the animal remembers the original and updated training locations [41].…”

Section: Objects In Updated Locationsmentioning

confidence: 99%

“…Finally, OUL is also ideal for studying the molecular mechanisms uniquely engaged by reconsolidation-dependent memory updating, as the only difference between a memory update session and the original training session is the animal's training history (i.e., whether the animal has already experienced one of those objects in a different location). The OUL paradigm, therefore, has a few advantages that can be leveraged to understand the cellular and molecular basis of reconsolidation-dependent memory updating [2,41].…”

Section: Objects In Updated Locationsmentioning

confidence: 99%

“…Much of the subsequent work on reconsolidation has been performed using fear conditioning, but in recent years, this work has been extended to multiple types of memory, including spatial, taste, and human episodic memory paradigms [ 1 , 16 ] (more on paradigms in Section 3 ). These paradigms have been used in many different species, from medaka fish [ 28 ] to honeybees [ 29 , 30 ], nematodes [ 31 ], snails [ 32 ], crabs [ 33 ], and chickens [ 34 ], with most of the work performed in mice [ 2 , 12 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ], humans [ 52 , 53 , 54 , 55 , 56 , 57 , 58 ], and rats [ 6 , 8 , 9 , 13 , 14 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 28 , 59 , 60 , 61 , 62 ,…”

Section: Rediscovery Of Reconsolidationmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Mechanisms of Reconsolidation-Dependent Memory Updating

Bellfy

Kwapis

2020

IJMS

Self Cite

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Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a reconsolidation-dependent updating process. For a previously stable memory to be updated, the memory must first become labile through a process called destabilization. Destabilization is a protein degradation-dependent process that occurs when new information is presented. Following destabilization, a memory becomes stable again through a protein synthesis-dependent process called restabilization. Much work remains to fully characterize the mechanisms that underlie both destabilization and subsequent restabilization, however. In this article, we briefly review the discovery of reconsolidation as a potential mechanism for memory updating. We then discuss the behavioral paradigms that have been used to identify the molecular mechanisms of reconsolidation-dependent memory updating. Finally, we outline what is known about the molecular mechanisms that support the memory updating process. Understanding the molecular mechanisms underlying reconsolidation-dependent memory updating is an important step toward leveraging this process in a therapeutic setting to modify maladaptive memories and to improve memory when it fails.

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Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments

Alaghband

Klein

Kramár

et al. 2023

Cell. Mol. Life Sci.

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Technological advancements have facilitated the implementation of realistic, terrestrial-based complex 33-beam galactic cosmic radiation simulations (GCR Sim) to now probe central nervous system functionality. This work expands considerably on prior, simplified GCR simulations, yielding new insights into responses of male and female mice exposed to 40–50 cGy acute or chronic radiations relevant to deep space travel. Results of the object in updated location task suggested that exposure to acute or chronic GCR Sim induced persistent impairments in hippocampus-dependent memory formation and reconsolidation in female mice that did not manifest robustly in irradiated male mice. Interestingly, irradiated male mice, but not females, were impaired in novel object recognition and chronically irradiated males exhibited increased aggressive behavior on the tube dominance test. Electrophysiology studies used to evaluate synaptic plasticity in the hippocampal CA1 region revealed significant reductions in long-term potentiation after each irradiation paradigm in both sexes. Interestingly, network-level disruptions did not translate to altered intrinsic electrophysiological properties of CA1 pyramidal cells, whereas acute exposures caused modest drops in excitatory synaptic signaling in males. Ultrastructural analyses of CA1 synapses found smaller postsynaptic densities in larger spines of chronically exposed mice compared to controls and acutely exposed mice. Myelination was also affected by GCR Sim with acutely exposed mice exhibiting an increase in the percent of myelinated axons; however, the myelin sheathes on small calibur (< 0.3 mm) and larger (> 0.5 mm) axons were thinner when compared to controls. Present findings might have been predicted based on previous studies using single and mixed beam exposures and provide further evidence that space-relevant radiation exposures disrupt critical cognitive processes and underlying neuronal network-level plasticity, albeit not to the extent that might have been previously predicted.

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Investigating Memory Updating in Mice Using the Objects in Updated Locations Task

Cited by 13 publications

References 29 publications

Dopamine activity on the perceptual salience for recognition memory

Dopamine activity on the perceptual salience for recognition memory

Molecular Mechanisms of Reconsolidation-Dependent Memory Updating

Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments

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