Investigating Lysine Adsorption on Fumed Silica Nanoparticles

Guo, Chengchen; Holland, Gregory P.

doi:10.1021/jp508627h

Cited by 54 publications

(60 citation statements)

References 77 publications

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“…Most intensity correlations in this 2D spectrum originate from directly bound intraresidue 1 H and 13 C nuclei, which allows their assignments to specific 1 H and 13 C moieties of the lysine, tyrosine, cysteine and glycine residues of the Tyr peptide. These resonance assignments are corroborated by the solid-and solution-state NMR spectra of neat peptides and polypeptides reported in the literature [36][37][38][39][40] .…”

Section: Resultssupporting

confidence: 72%

Tuning underwater adhesion with cation–π interactions

et al. 2017

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In this Article we described a ruthenium-catalysed carbonyl addition method for alcohol production via simple unsubstituted hydra-zone intermediates, but we inadvertently omitted the citation of two papers that had previously reported a similar carbanion reactivity 1,2. In these papers, the authors illustrated a series of substituted hindered hydrazones (for example, tert-butyl-, trityl-and diphenyl-4-pyri-dylmethyl) for additions to carbonyl compounds; however, to yield the target alcohols under these circumstances, the lithium salts of these hydrazones had to be pre-formed, with subsequent CC bond formation and removal of bulky substituents on azo-intermediates via radical decomposition. References 1. Baldwin, J. E. et al. Azo anions in synthesis: use of trityl-and diphenyl-4-pyridylmethylhydrazones for reductive C−C bond formation. Tetrahedron 42, 4235−4246 (1986). 2. Baldwin, J. E., Bottaro, J. C., Kolhe, J. N. & Adlington, R. M. Azo anions in synthesis. Use of trityl-and diphenyl-4-pyridylmethyl-hydrazones for reductive CC bond formation from aldehydes and ketones. J. Chem. Soc. Chem. Commun. 22−23 (1984). Addendum: Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e. A l l r i g h t s r e s e r v e d .

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Section: Resultssupporting

confidence: 72%

Tuning underwater adhesion with cation–π interactions

et al. 2017

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“…demonstrated that hydrogen bonds participate in the binding of peptides to titania with NMR spectroscopy . Similar involvement of hydrogen bonds can be evidenced with NMR for amino acids and peptides on silica surfaces In addition, the binding of the amino acid lysine through hydrogen bonds to silica was demonstrated by NMR spectroscopy . The binding of cysteine containing peptides to noble metal surfaces has been verified with NMR spectroscopy as well .…”

Section: Structural and Mechanistic Description Of Peptide‐surface Insupporting

confidence: 59%

“…Other destructive techniques, like induced coupled plasma, also yield the equilibrium constant by quantifying individual elements . While a determination of the binding capacity of organic molecules on inorganic surfaces is possible, the equilibrium constant K D calculated from TGA results is often higher than with other methods indicating a lower thermodynamic probability of the surface to bind the molecules but the lower sensitivity might falsify the binding constant . In several cases the analysis of the binding affinity by analysis of adsorbent in the supernatant (liquid sample) and adsorbate on the adsorber (solid sample) yielded similar results .…”

Section: Determination Of Binding Affinitiesmentioning

confidence: 99%

Experimental characterization and simulation of amino acid and peptide interactions with inorganic materials

Schwaminger

Blank-Shim

Borkowska-Panek

et al. 2017

Engineering in Life Sciences

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Inspired by nature, many applications and new materials benefit from the interplay of inorganic materials and biomolecules. A fundamental understanding of complex organic–inorganic interactions would improve the controlled production of nanomaterials and biosensors to the development of biocompatible implants for the human body. Although widely exploited in applications, the interaction of amino acids and peptides with most inorganic surfaces is not fully understood. To date, precisely characterizing complex surfaces of inorganic materials and analyzing surface–biomolecule interactions remain challenging both experimentally and computationally. This article reviews several approaches to characterizing biomolecule–surface interactions and illustrates the advantages and disadvantages of the methods presented. First, we explain how the adsorption mechanism of amino acids/peptides to inorganic surfaces can be determined and how thermodynamic and kinetic process constants can be obtained. Second, we demonstrate how this data can be used to develop models for peptide–surface interactions. The understanding and simulation of such interactions constitute a basis for developing molecules with high affinity binding domains in proteins for bioprocess engineering and future biomedical technologies.

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“…Until recently, only the structures of Au 23 (SC 6 H 11 ) 16 , Au 25 (PET) 18 , Au 25 (SEt) 18 , Au 28 (TBBT) 20 , Au 36 (SPh‐tBu) 24 , Au 38 (SR) 24 , and Au 102 (p‐MBA) 44 have been successfully determined by X‐ray crystallography. Comparing with all these techniques, nuclear magnetic resonance (NMR) spectroscopy has been demonstrated to be a universal and versatile technique for characterization of nanomaterials . One‐dimensional/multidimensional NMR spectroscopy combined with homonuclear/heteronuclear NMR spectroscopy provides considerable methods for characterizing nanostructures including purity, ligand density, and surface chemistry .…”

Section: Introductionmentioning

confidence: 99%

Characterizing gold nanoparticles by NMR spectroscopy

Guo

Yarger

2018

Magnetic Reson in Chemistry

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Gold nanoparticles have attracted considerable attention in recent research because of their wide applications in various fields such as material science, electrical engineering, physical science, and biomedical engineering. Researchers have developed many methods for synthesizing different kinds of gold nanoparticles, where the sizes and surface chemistry of the nanoparticles are considered to be the two key factors. Traditionally, the sizes of nanoparticles are determined by electron microscopy whereas the surface chemistry is characterized by optical spectroscopies such as infrared spectroscopy and Raman spectroscopy. Compared with that, nuclear magnetic resonance (NMR) spectroscopy provides a more advanced and convenient way for size determination and surface chemistry investigations by combining one- and multiple-dimensional NMR spectroscopy and diffusion-order NMR spectroscopy. Here, we show a thorough study that NMR spectroscopy can be applied to characterize small thiol-protected gold nanoparticles, including size determination, surface chemistry investigation, and structural study. The results show that the nanoparticles' sizes determined by NMR agree well with transmission electron microscopy results. Furthermore, the ligand densities of nanoparticles were determined by quantitative NMR spectroscopy, and the structures of ligands capped on the surfaces were studied thoroughly by one- and multiple-dimensional NMR spectroscopy. In this work, we establish a general method for researchers to characterize nanostructures by using NMR spectroscopy.

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Investigating Lysine Adsorption on Fumed Silica Nanoparticles

Cited by 54 publications

References 77 publications

Tuning underwater adhesion with cation–π interactions

Tuning underwater adhesion with cation–π interactions

Experimental characterization and simulation of amino acid and peptide interactions with inorganic materials

Characterizing gold nanoparticles by NMR spectroscopy

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