Investigating indicators and determinants of asthma in young adults

Grassi, Mario; Bugiani, Massimiliano; Marco, Roberto de

doi:10.1007/s10654-006-9062-5

Cited by 11 publications

(7 citation statements)

References 46 publications

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“…The latter factor disagrees with recent research that suggests that individuals with a genetic record of asthma are more likely to develop asthma in young adulthood (Grassi, Bugian, and de Marco 2006). Results also indicate that physiological factors play a significant role in long-term respiratory health.…”

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confidence: 87%

Does Chronic Exposure to Air Pollution in Childhood Impact Long-Term Respiratory Health?

Barakat-Haddad

Elliott

Pengelly

2012

The Professional Geographer

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This study seeks to examine the relationship between childhood exposure to air pollution and long-term respiratory health and to identify significant predictors of respiratory health in adulthood. Logistic regression modeling was undertaken using health and exposure data for 395 participants who resided during childhood in four distinct neighborhoods in Hamilton, Ontario, Canada. Significant predictors include exposure to SO 2 in childhood, location of residence in childhood, sex, residential and occupational histories, stressful life events, and respiratory health in childhood. This study suggests that the health impacts of childhood exposure to air pollution are located beyond the short-term period that most research addresses. Key Words: air pollution, children, cohort, health geography, respiratory health.El doble propósito de este estudio es examinar la relación existente entre la exposición de la niñez a la contaminación aérea y la salud respiratoria a largo plazo, e identificar predictores significativos de la salud respiratoria en los adultos. Se acometió un modelaje de regresión logística utilizando datos de salud y exposición de 395 participantes que durante su niñez residieron en cuatro vecindarios diferentes en Hamilton, Ontario, Canadá. Los predictores significativos incluyen la exposición a SO 2 durante la niñez, localización del lugar de residencia en la niñez, sexo, historias residenciales y ocupacionales, eventos estresantes a lo largo de la vida y salud respiratoria en la niñez. El estudio sugiere que los impactos sobre la salud por exposición a la contaminación aérea en la niñez se ubican más allá del corto período del que se ocupan la mayoría de las investigaciones. Palabras clave: contaminación aérea, niños, cohorte, geografía de la salud, salud respiratoria.

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contrasting

confidence: 87%

Does Chronic Exposure to Air Pollution in Childhood Impact Long-Term Respiratory Health?

Barakat-Haddad

Elliott

Pengelly

2012

The Professional Geographer

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“…The effects of exposure to SHS on asthma outcomes are well documented, including in work from earlier waves of participation by the cohort we analyze here (Eisner et al 2002; Eisner et al 2005; Eisner 2008). Nonetheless, exposure assessments in epidemiological studies of the relationship between SHS and asthma outcomes are typically based on questionnaire data (Eisner et al 2002; Grassi et al 2006; Hersoug et al ; Jaakkola et al 2003; Janson et al 2001; Jayet et al 2005; Jindal et al 1994). Because over 90% of our subjects were not current smokers, our study is one of the first to assess exposure to SHS in adult asthma with a measured biomarker, hair nicotine.…”

Section: Discussionmentioning

confidence: 99%

Annual average ambient particulate matter exposure estimates, measured home particulate matter, and hair nicotine are associated with respiratory outcomes in adults with asthma

Balmes

Cisternas

Quinlan

et al. 2014

Environmental Research

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Background While exposure to outdoor particulate matter (PM) has been associated with poor asthma outcomes, few studies have investigated the combined effects of outdoor and indoor PM (including secondhand tobacco smoke). Objective To examine the associations between PM and asthma outcomes. Methods We analyzed data from a cohort of adults with asthma and rhinitis (n=302; 82% both conditions; 13% asthma only; 5% rhinitis alone) including measures of home PM, tobacco smoke exposure (hair nicotine and self-report), ambient PM from regional monitoring, distance to roadway, and season (wet or dry). The outcomes of interest were frequent respiratory symptoms and forced expiratory volume in 1 second (FEV1) below the lower limit of normal (NHANES reference values). Multivariable regression analyses examined the associations (Odds Ratio [OR] and 95% Confidence Interval [95%CI]) between exposures and these outcomes, adjusted by sociodemographic characteristics. Results In adjusted analyses of each exposure, the highest tertile of home PM and season of interview were associated with increased odds for more frequent respiratory symptoms (OR=1.64 95%CI: [1.00, 2.69] and OR = 1.66 95%CI: [1.09, 2.51]). The highest tertile of hair nicotine was significantly associated with FEV1 below the lower limit of normal (OR=1.80 95%CI: [1.00, 3.25]). In a model including home PM, ambient PM, and hair nicotine, and season, only two associations remained strong: hair nicotine with FEV1 below the lower limit of normal and season of measurement (dry, April-October) with increased respiratory symptoms (OR=1.85 95%CI: [1.00, 3.41] and OR = 1.54 95%CI: [1.0, 2.37]). When that model was stratified by sex, the highest tertiles of ambient PM and hair nicotine were associated with FEV1 below the lower limit of normal among women (OR=2.23 95%CI: [1.08, 4.61] and OR=2.90 95% CI: [1.32, 6.38]), but not men. The highest tertile of hair nicotine was also associated with increased respiratory symptoms in women but not men (OR=2.38 95% CI: [1.26, 4.49]). When stratified by age, the middle quartile of ambient PM and the highest hair nicotine tertile were associated with increased respiratory symptoms (OR=2.07 95%CI: [1.01, 4.24] and OR=2.55 95%CI: [1.21,5.36]) in those under 55 but not in the older stratum. Conclusions Exposure to PM from both home and ambient sources is associated with increased symptoms and lower lung function in adults with asthma, although these associations vary by type of PM, the respiratory outcome studied, sex and age.

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“…Multiple factors play a role in the development of asthma and the exacerbation of asthma symptoms. It is believed that genetic predisposition, exposure to environmental factors, and significant gene-environment interactions may influence development of asthma and exacerbation of the symptoms (6)(7)(8)(9)(10)(11). Genetic predisposition may lead to the development of asthma and allergies (e.g., atopic dermatitis [eczema] or allergic rhinitis [hay fever]) (6,8).…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Asthma Prevalence among Racial and Ethnic Groups—United States, 2009–2010 Behavioral Risk Factor Surveillance System

Zahran

Bailey

2013

Journal of Asthma

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Investigating indicators and determinants of asthma in young adults

Cited by 11 publications

References 46 publications

Does Chronic Exposure to Air Pollution in Childhood Impact Long-Term Respiratory Health?

Does Chronic Exposure to Air Pollution in Childhood Impact Long-Term Respiratory Health?

Annual average ambient particulate matter exposure estimates, measured home particulate matter, and hair nicotine are associated with respiratory outcomes in adults with asthma

Factors Associated with Asthma Prevalence among Racial and Ethnic Groups—United States, 2009–2010 Behavioral Risk Factor Surveillance System

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