Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging
Naibedya Dutta,
Joe A Gerke,
Sofia F Odron
et al.
Abstract:Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine spongeC. mycofijiensisand its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemical probes based on their high efficiency to inhibit ETC complex I function. Similar to rotenone (Rote), a widely used … Show more
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