Investigating how cancer-related symptoms influence work outcomes among cancer survivors: a systematic review

Tan, Chia Jie; Yip, Samantha Yin Ching; Chan, Raymond Javan; Chew, Lita; Chan, Alexandre

doi:10.1007/s11764-021-01097-5

Cited by 31 publications

(36 citation statements)

References 69 publications

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“…Secondary outcomes, such as anxiety and depression, fatigue and sleep (measured with self-reported instruments, for instance, the Hospital Anxiety and Depression Scale and the EORTC QLQ-C30, respectively 26 ), age, type of cancer and type of treatment (as presented in demographic and clinical characterisation of the sample), will also be considered.…”

Section: Methods and Analysismentioning

confidence: 99%

“…The latest model was developed by Mehnert et al 22 and corresponds to a cancer survivorship and work model adapted from Feuerstein et al 16 and Mehnert, 14 considering several work-related outcomes, such as employment/return to work, work ability, work performance, job opportunities, income, work satisfaction, job promotion and training, and sustainability. Nevertheless, since the publication of these theoretical models, a growing body of research has been developed to study the relationship between CRCI and work-related outcomes, including some reviews to systematise studies' findings, [23][24][25][26] considering that many occupationally active survivors identify these symptoms as very problematic and bothersome. 18 Von Ah et al 23 were the first to explore the impact of cognitive impairment on work outcomes in 2016.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…28 This is important to clinical practice because, by combining information from all relevant studies, meta-analyses can provide more objective and precise estimates of the effects of healthcare than those derived from the individual studies included within a review, assisting clinicians decisions. 29 30 Consequently, a quantitative investigation of this association is necessary and timely, as suggested by Tan et al 26 Considering the growing attention that has been given to this area in recent years, the primary aim of the present systematic review with meta-analysis is to comprehensively review the literature and synthesise relevant data to identify the relationship between CRCI and work-related outcomes of adult non-CNS cancer survivors at working age, and to quantify this association, exploring how strong and consistent is the relationship across studies. If possible, a secondary examination of patient and clinical characteristics (eg, age, type of cancer, type of treatment), psychological variables (eg, depression, anxiety) and other influencing factors (eg, fatigue, sleep) and their influence on any association between CRCI and work-related outcomes will also be conducted.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…Although discrepancies were found between results from neuropsychological testing and self-report measures, breast cancer survivors can experience challenges in their employment due to cognitive deficits, which may lead to the loss of their employment. In the same year, Tan et al 26 performed a systematic review of studies that quantified the impact of cancer-related symptoms (namely cognitive impairment) on work outcomes among cancer survivors. Results indicated that only a small proportion of studies assessing work status (employment status/return to work or early retirement/work disability) and cognitive impairment reported significant findings.…”

Section: Introductionmentioning

confidence: 99%

“… 29 30 Consequently, a quantitative investigation of this association is necessary and timely, as suggested by Tan et al . 26 …”

Section: Introductionmentioning

confidence: 99%

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Cognitive functioning and work-related outcomes of non-central nervous system cancer survivors: protocol for a systematic review with meta-analysis

et al. 2022

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IntroductionIn recent years, growing attention has been given to the study of the impact of cancer-related cognitive impairment (CRCI) in working non-central nervous system (CNS) cancer survivors. Available literature has shown that working cancer survivors identify cognitive problems at work as very problematic and worrisome. Some reviews have discussed the association between CRCI and work-related outcomes; however, none to date have investigated this association through comprehensive systematic review with meta-analysis. Hence, this work will comprehensively summarise existing evidence from quantitative studies assessing the relationship between CRCI and work-related outcomes of adult non-CNS cancer survivors at working age.Methods and analysisThe systematic review procedures and its report will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Electronic searches in the databases Web of Science, Scopus, PubMed, ProQuest, PsycINFO and CINAHL, complemented by a manual search of other relevant articles, will be performed from 2000 onwards to identify relevant publications. Two independent reviewers will assess studies for inclusion and extract data from each article using a standardised form. Studies eligible for inclusion must be quantitative, contain adult non-CNS cancer survivors with CRCI, and a measure of cognitive functioning and work-related outcomes. To assess risk of bias, the Joanna Briggs Institute Critical Appraisal Tool Studies checklists will be independently used by the two researchers. Synthesis of the included articles will be conducted using a narrative method and through meta-analysis. Meta-analysis will be reported via correlation for the association between CRCI and work-related outcomes. The cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation system.Ethics and disseminationEthics approval is not required since individual patient data will not be collected. The findings will be published in a peer-review indexed journal, presented at scientific meetings and included in a chapter of a Doctoral thesis.PROSPERO registration numberCRD42020165458.

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Section: Methods and Analysismentioning

confidence: 99%

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 29 30 Consequently, a quantitative investigation of this association is necessary and timely, as suggested by Tan et al . 26 …”

Section: Introductionmentioning

confidence: 99%

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Cognitive functioning and work-related outcomes of non-central nervous system cancer survivors: protocol for a systematic review with meta-analysis

et al. 2022

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Cognition and Return to Work Status 2 Years After Breast Cancer Diagnosis

Lange,

Lequesne,

Dumas

et al. 2024

JAMA Netw Open

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ImportanceReturn to work after breast cancer (BC) treatment depends on several factors, including treatment-related adverse effects. While cancer-related cognitive impairment is frequently reported by patients with BC, to date, no longitudinal studies have assessed its association with return to work.ObjectiveTo examine whether cognition, assessed using objective and subjective scores, was associated with return to work 2 years after BC diagnosis.Design, Setting, and ParticipantsIn a case series of the French Cancer Toxicities (CANTO) cohort, a study of patients with stage I to III BC investigated cognition from April 2014 to December 2018 (2 years’ follow-up). Participants included women aged 58 years or younger at BC diagnosis who were employed or looking for a job.Main Outcomes and MeasuresThe outcome was return to work assessed 2 years after BC diagnosis. Objective cognitive functioning (tests), cognitive symptoms, anxiety, depression, and fatigue were prospectively assessed at diagnosis (baseline), 1 year after treatment completion, and 2 years after diagnosis. Multivariable logistic regression models were used to explain return to work status at year 2 according to each cognitive measure separately, adjusted for age, occupational class, stage at diagnosis, and chemotherapy.ResultsThe final sample included 178 women with BC (median age: 48.7 [range, 28-58] years), including 37 (20.8%) who did not return to work at year 2. Patients who returned to work had a higher (ie, professional) occupational class and were less likely to have had a mastectomy (24.1% vs 54.1%; P &lt; .001). Return to work at year 2 was associated with lower overall cognitive impairment (1-point unit of increased odds ratio [1-pt OR], 0.32; 95% CI, 0.13-0.79; P = .01), higher working memory (1-pt OR, 2.06; 95% CI, 1.23-3.59; P = .008), higher processing speed (1-pt OR, 1.97; 95% CI, 1.20-3.36; P = .01) and higher attention performance (1-pt OR, 1.63; 95% CI, 1.04-2.64; P = .04), higher perceived cognitive abilities (1-pt OR, 1.12; 95% CI, 1.03-1.21; P = .007), and lower depression (1-pt OR, 0.83; 95% CI, 0.74-0.93; P = .001) at year 2 assessment. Return to work at year 2 was associated with several measures assessed at baseline and year 1: higher processing speed (1-pt OR, 2.38; 95% CI, 1.37-4.31; P = .003 and 1.95; 95% CI, 1.14-3.50; P = .02), higher executive performance (1-pt OR, 2.61; 95% CI, 1.28-5.75; P = .01, and 2.88; 95% CI, 1.36-6.28; P = .006), and lower physical fatigue (10-pt OR, 0.81; 95% CI, 0.69-0.95; P = .009 and 0.84; 95% CI, 0.71-0.98; P = .02).Conclusions and RelevanceIn this case series study of patients with BC, return to work 2 years after diagnosis was associated with higher cognitive speed performance before and after BC treatment. Cognitive difficulties should be assessed before return to work to propose suitable management.

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Neuropsychiatric complications and associated management in adolescent and young adult cancer survivors: An All of Us study

Agapito,

Ng,

Milam

et al. 2023

Cancer Medicine

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BackgroundAbout 4.5% of new cancer cases affect adolescent and young adult aged between 15 and 39 years in the United States (US). However, the effect of neuropsychiatric conditions on long‐term adolescent and young adult cancer (AYAC) survivors has not been formally investigated. Thus, the impact and management of late neuropsychiatric complications in AYAC survivors compared to non‐cancer‐matched controls (NCMC) in the US were evaluated using the All of Us (AoU) Research Program.MethodsParticipants in the AoU Controlled Tier Dataset (v6) diagnosed with cancer between ages 15 and 39 were identified from electronic health records and surveys. AYAC survivors were matched with NCMC using the optimal pair‐matching algorithm at a 1:4 ratio. Data on past diagnoses, current follow‐up care, and treatment patterns of neuropsychiatric complications were collected.ResultsAnalysis was performed on 788 AYAC survivors and 3152 NCMC. AYAC survivors, with an average of 8.8 years since their first cancer diagnosis, were more likely than NCMC to receive a diagnosis of neuropathy, memory loss and epilepsy (p < 0.001). Survivors also had a higher rate of follow‐up care and treatment utilization for these neurological conditions compared to NCMC (p < 0.05). Treatment utilization was highest among survivors receiving care for epilepsy (88%), and lower for neuropathy (70%), memory loss (61%), and chronic fatigue (59%).ConclusionsThis large study reveals that AYAC survivors, on average 9 years after their cancer diagnosis, require more frequent follow‐up care for neurological complications compared to non‐cancer individuals. However, the management of neuropathy, memory loss, and chronic fatigue is hindered by a lack of mechanism‐based effective therapies.

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Investigating how cancer-related symptoms influence work outcomes among cancer survivors: a systematic review

Cited by 31 publications

References 69 publications

Cognitive functioning and work-related outcomes of non-central nervous system cancer survivors: protocol for a systematic review with meta-analysis

Cognitive functioning and work-related outcomes of non-central nervous system cancer survivors: protocol for a systematic review with meta-analysis

Cognition and Return to Work Status 2 Years After Breast Cancer Diagnosis

Neuropsychiatric complications and associated management in adolescent and young adult cancer survivors: An All of Us study

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