Investigating children’s chemical exposome – Description and possible determinants of exposure in the region of Luxembourg based on hair analysis

Iglesias-González, Alba; Schweitzer, Mylène; Palazzi, Paul; Peng, Feng-Jiao; Haan, Serge; Letellier, Elisabeth; Appenzeller, B.M.R.

doi:10.1016/j.envint.2022.107342

Cited by 15 publications

(5 citation statements)

References 55 publications

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“…Variability in hair sample composition among populations in Italy (PFOA and PFOS), Spain (PFHpA and PFOS), and India (PFHxS, PFOS, and PFOA) may be attributable to geographical distinctions. − It is worth noting that median BPA levels were 2–5 times lower than those observed in EU populations such as those in Greece, Belgium, and Luxembourg . Furthermore, median BPS concentrations were 4 times lower than those in Belgium and Luxembourg . Taken together, the hair concentrations of PFRs, PFAS, and BPs in this study were relatively low compared to those reported in previous studies, likely due to the small sample size.…”

Section: Discussionmentioning

confidence: 92%

“…Median concentrations of ∑ 18 PFAS in hair exceeded those observed in populations in Italy, Spain, and India. − Particularly notable were the higher proportions of PFHxS, PFHxDA, and PFOA, indicative of representative chemicals. Variability in hair sample composition among populations in Italy (PFOA and PFOS), Spain (PFHpA and PFOS), and India (PFHxS, PFOS, and PFOA) may be attributable to geographical distinctions. − It is worth noting that median BPA levels were 2–5 times lower than those observed in EU populations such as those in Greece, Belgium, and Luxembourg . Furthermore, median BPS concentrations were 4 times lower than those in Belgium and Luxembourg .…”

Section: Discussionmentioning

confidence: 97%

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Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Huang,

Liao,

Yang

et al. 2024

Environ. Sci. Technol. Lett.

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Hair is a valuable, non-invasive material for human biomonitoring. However, little is known about polluting contaminants in hair, particularly regarding the relationship between biocomponents and contaminant levels in hair. We measured the concentrations of 42 contaminants, including 11 phosphorus flame retardants (PFRs), 13 bisphenols (BPs), and 18 perfluoroalkyl and polyfluoroalkyl substances (PFAS), while simultaneously measuring the levels of keratin, melanin, and eight sphingolipids in hair samples. Long-chain sphingolipids (C20CER) were negatively associated with levels of PFRs, PFAS, and BPs, while C12CER and C14CER (short-chain) were positively associated with levels of PFRs and BPs. Furthermore, we observed an overall negative association between ∑7PFRs and endogenous biocomponents but a positive dose–effect relationship with ∑5BPs and biocomponents using Bayesian kernel machine regression models. Among the biocomponents, C20CER and C14CER contributed the most to the negative and positive associations, respectively. Specifically, a change in Ln C20CER (Z-score) concentration from the 25th to 75th percentile was associated with a decrease in ∑7PFRs of 47.0%-SD (−61.8%, −32.3%) when other biocomponents were at their median values. These findings provide new insights into the relationships between biocomponents and contaminants in hair, which is an essential step for the advancement of hair as a biomonitoring material.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Huang,

Liao,

Yang

et al. 2024

Environ. Sci. Technol. Lett.

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“…In many biomonitoring studies, pesticide exposure has been accurately tracked through hair concentrations [109][110][111][112][113][114][115][116][117][118][119][120]. The ability to track pesticide residue in hair shafts indicates that pesticides may have significant accumulation in the HF.…”

Section: Pesticides and Insecticidesmentioning

confidence: 99%

The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology

Samra,

Lin,

Maderal

2024

Skin Appendage Disord

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Background: Environmental exposures profoundly impact cutaneous physiology, with hair follicles (HFs) being particularly vulnerable due to their high levels of proliferation and perfusion. HFs are exposed directly to contaminants that are absorbed transcutaneously and exposed indirectly to ingested and inhaled pollutants via the bloodstream. Summary: Some pollutants, such as particulate matter, trigger inflammatory responses and have been associated with alopecia areata. Others, like tobacco smoke and phthalates, exert endocrine effects with unclear ramifications for HF function. Pesticides and heavy metals have both been linked to alopecia areata and acute anagen effluvium, while polyaromatic hydrocarbons – ligands of aryl hydrocarbon receptors – are linked to androgenetic alopecia. Finally, UV exposure, which has increased due to anthropogenic ozone depletion, causes oxidative damage and perifollicular mast cell degranulation. Key Messages: Pollutants have far-reaching consequences for hair pathology, which remain incompletely characterized. The effects of environmental exposures on HFs are an active area of research that deserve further attention.

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“…Although biological fluids such as urine and blood are the most popular matrices for the assessment of exposure to various pollutants, increasing interest is also observed for hair analysis. Indeed, although the first studies analyzing organic pollutants in hair were limited to persistent organic pollutants, the list of chemicals detected in hair was rapidly extended over the past decade, including several types of nonpersistent contaminants such as pesticides, bisphenols, and phthalate metabolites. − ,,, . In parallel, several experimental studies were conducted to address the aspects possibly limiting the use of this matrix for assessing exposure to pollutants.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, although the first studies analyzing organic pollutants in hair were limited to persistent organic pollutants, 11 extended over the past decade, including several types of nonpersistent contaminants such as pesticides, bisphenols, and phthalate metabolites. [12][13][14][15][16][17]5,3,18 . In parallel, several experimental studies were conducted to address the aspects possibly limiting the use of this matrix for assessing exposure to pollutants.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics–Implications for Exposure Assessment

Faÿs

Palazzi

Zeman

et al. 2023

Environ. Sci. Technol.

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Mechanisms governing chemicals’ incorporation in hair are incompletely understood, and gaps remain to link the concentration of chemicals in hair to level of exposure and internal dose present in the body. This study assesses the relevance of hair analysis for the biomonitoring of exposure to fast-elimination compounds and investigates the role of pharmacokinetics (PK) in their incorporation in hair. Rats were administered with pesticides, bisphenols, phthalates, and DINCH over 2 months. Hairs were analyzed for 28 chemicals/metabolites to investigate correlations between their concentration in hair and the dose administered to the animals. Urine collected over 24 h after gavage was used to determine chemicals’ PK and to investigate their influence on incorporation into hair by means of linear mixed models (LMMs). Eighteen chemicals presented a significant correlation between concentration in hair and level of exposure. In models combining all chemicals, agreement between concentration in hair predicted by LMM and experimental values was moderate (R 2 = 0.19) but significantly increased when PK were included in the models (R 2 = 0.37), and even more when chemical families were considered separately (e.g., R 2 = 0.98 for pesticides). This study shows that pharmacokinetics mediate incorporation of chemicals in hair and suggests the relevance of hair for assessing exposure to fast-elimination chemicals.

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Investigating children’s chemical exposome – Description and possible determinants of exposure in the region of Luxembourg based on hair analysis

Cited by 15 publications

References 55 publications

Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology

Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics–Implications for Exposure Assessment

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