Investigação da associação de variantes polimórficas, sítios de metilação e tamanho de telômeros com resposta a longo prazo de lítio em transtorno bipolar

Abstract

Serotonin receptor 5-HTTLPR-serotonin-transporter-linked polymorphic region AC-Adenilil Ciclase ACCN1-amiloride-sensitive cation channel 1 AKT-Protein kinase B (PKB) AMI-Affective Morbidity Index AMPA-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ANK3-Ankyrin-3 APP-Amyloid beta precursor protein ATP-Trifosfato de adenosina BAX-B-cell lymphoma 2 associated X protein BCL2-B-cell lymphoma 2 BCL2L11-BCL2 Like 11 BCR-breakpoint cluster region BDNF-Brain derived neurotrophic factor BDNF-Met-alelo codificante de metionina do polimorfismo Val66Met do BDNF BMAL1/ARNTL-Basic helix-loop-helix/PAS protein BPRS-Brief Psychiatric Rating Scale BRCA1-Breast Cancer 1 CACNA1C-calcium channel, voltage-dependent, L type, alpha 1C subunit CACNB4-calcium channel, voltage-dependent, beta 4 subunit cAMP-cyclic adenosine monophosphate CGI

Telomere length: biological marker of cellular vitality, aging, and health-disease process

“…Functioning as an important biomarker of cellular vitality or activity, longevity or aging, and the health-disease process, measuring the telomere length of leukocytes DNA extracted from peripheral blood 67 provides clinical and dynamic parameters of health and well-being and can be used as a diagnostic and prognostic method of the illness process 31,[68][69][70] , as well as measuring the efficacy and effectiveness of various therapies employed, conventional 71 or nonconventional (e.g., homeopathy 72 , acupuncture 73 , and meditation 74 ).…”