Inverting papillomas of the nose and paranasal sinuses

Calcaterra, Thomas C.; Thompson, J. W.; Paglia, Donald E.

doi:10.1288/00005537-198001000-00006

Cited by 109 publications

(58 citation statements)

References 11 publications

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“…In the era when transnasal resection without endoscopic or microscopic assistance was the most commonly used technique, the percentage of 'recurrences' ranged from 40% (83) to 78% (84). We concur with many authors (7,85) that most of these 'recurrences' are basically 'residual' lesions as the exposure offered by the transnasal approach did not guarantee the adequate radicality of the resection.…”

Section: Surgical Advancesmentioning

confidence: 54%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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Section: Surgical Advancesmentioning

confidence: 54%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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“…Inverted papillomas commonly occur in the nasal cavity and paranasal sinuses of humans and have also been found in the urinary bladder. [1][2][3]9 Human papillomavirus antigens (HPV) were found in one case of an inverted papilloma of the nasal cavity. l 8 Cytopathic effects of papillomaviruses include dyskeratosis of the superficial epithelium and the presence of koilocytotic cells.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous Inverted Papillomas in Dogs

et al. 1988

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Abstract. Inverted papillomas of the skin occurred in five dogs. Lesions were 1-2 cm, circumscribed, flasklike structures below the level of the surrounding normal skin. Walls of the structures consisted of hyperplastic epidermis, forming thin papillary projections on thin fibrovascular stalks. Cells in the stratum granulosum had clear cytoplasm, numerous keratohyalin-like granules of various sizes, and poorly defined intranuclear inclusions. These cells stained positively for papillomavirus group-specific antigens by both the peroxidase-antiperoxidase and avidin-biotin methods. Virions with a mean diameter of 35.7 nm were present within nuclei in cells of the stratum granulosum when examined by electron microscopy. In situ DNA hybridization, using a canine oral papillomavirus probe, localized papillomavirus DNA in canine oral papillomas, but not in canine cutaneous squamous or inverted papillomas, suggesting that a different papillomavirus type was present in the latter lesions. Although these lesions resembled intracutaneous cornifying epitheliomas (keratoacanthomas), they appear to be a distinct lesion, probably with a different etiology Dogs develop a variety of cutaneous neoplasms; the etiology of many are unknown. Papillomavirus antigens have been detected in cutaneous squamous papillomas and some squamous cell carcinomas, but not in canine intracutaneous cornifying epitheliomas, trichoepitheliomas, pilomatrixomas, or sebaceous adenomas. 16 We describe here five cases of inverted papillomas in dogs which superficially resemble intracutaneous cornifying epitheliomas (keratoacanthomas), are morphologically distinct from the common cutaneous squamous papilloma, and contain papillomavirus antigens. Materials and MethodsSurgical biopsies from five dogs were fixed in 10% neutral buffered formalin, processed routinely, embedded in paraffin, sectioned at 6 pm, and stained with hematoxylin and eosin (HE). Serial sections were tested for the presence of papillomavirus group-specific antigens by both the peroxidaseantiperoxidase (PAP)16 and avidin-biotin complex (ABC) techniques. Tissues removed from paraffin blocks of three cases were reembedded in epon-araldite, sectioned, and examined in an electron microscope to confirm the presence of virus.Sections for in situ hybridization were deparaffinized, treated with a prehybridization mixture of 50% deionized formamide in 0.3 M NaCl and 0.03 M Na, citrate, and incubated with the hybridization mixture.6 The hybridization mixture was prepared using cloned canine oral papillomavirus DNA24, nick translated in the presence of 66.8 pmoles ,%-labelled dATP.I3J7 The resulting 35S-labelled DNA had a specific activity of greater than 1 x lo8 cpmhg. Following a 4-hour incubation with the hybridization mixture, the sections were rinsed, dehydrated with ethanol, and applied to NTB-2 nuclear track emulsion (Kodak). The emulsion was exposed for 7 days, slides developed in a 1 : 1 mixture of D-19 (Kodak) and H,O, rinsed in 1 O/o glacial acetic acid, fixed in Kodak Rapid Fix, stained wi...

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“…The local aggressiveness, high rate of recurrence, associated malignancy and tendency to multicentricity are the clinical characteristics of inverted papilloma that have recently led most workers [7,8] to advocate radical surgical removal of these tumors. The incidence of recurrence has been observed directly related to the method of surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of recurrence has been observed directly related to the method of surgical treatment. The limited excision by intranasal polypectomy, turbinectomy or the Caldwell-luc has resulted in high recurrence rates of 73% [6] to 78% [7]. On the contrary, lateral rhinotomy performed in conjunction with medial maxillectomy is accompanied by a marked reduction in the incidence of recurrences, the fi gures varying from 0 -13% [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Surgical excision is generally regarded as the treatment of choice, but the approach and extent of surgery have been the subject of debate. Many workers have endorsed lateral rhinotomy and wide resection as the procedure of choice for all cases of inverted papilloma [6,7]. Of late, there has been a growing trend towards endoscopic removal of these tumours.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral aggressive inverted papillomas: A changing scenario

Panda

Saravanan

Verma

et al. 2007

Indian J Otolaryngol Head Neck S

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Objectives The ideal management of bilateral, recurrent inverted papillomas is intriguing and often controversial. We describe the ideal management of such tumors. Design Retrospective, case seriesMethods The three patients in this series inspite of several surgical procedures in the past had recurrences and behaved in an aggressive fashion. The patients underwent surgical excision by either bilateral lateral rhinotomy, midfacial degloving or craniofacial approaches.

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Inverting papillomas of the nose and paranasal sinuses

Cited by 109 publications

References 11 publications

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Cutaneous Inverted Papillomas in Dogs

Bilateral aggressive inverted papillomas: A changing scenario

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