Inverted Y chromosome polymorphism in the Gujerati Muslim Indian population of South Africa

Abstract

An inverted Y chromosome has been found at a very high frequency in a Muslim Indian community living in the Johannesburg-Witwatersrand area of the Transvaal Province of South Africa: 8 of 141 (5.7%) retrospectively identified Indian males had an inv(Y)(p11.2q11.23) and all were of the Muslim faith. The inversion was found in 22 of 72 (30.5%) prospectively studied normal Muslim Indian males. All the carriers of the inversion were Gujarati-speakers whose families migrated to the Transvaal from the Gujerat Province of India during the first half of this century. The origins of the ancestors of the individuals with inv(Y) were traced to a small village, Kholvad, near the city of Surat, and some neighbouring villages. The polymorphic frequency of the inv(Y) has probably been produced through random genetic drift in a reproductively isolated community, maintained by strict endogamous marriage customs based on religious and linguistic affiliations. There was no indication that the inverted Y was associated with any reproductive disadvantages.

AZF deletions and Y chromosomal haplogroups: history and update based on sequence

“…This Y chromosomal rearrangement reminds to the occurrence of a similiar inversion event in the Y chromosome of the Gujerati Muslim Indian population in South Africa (Bernstein et al, 1986). Although there are not yet any molecular experiments supporting this view, it can be assumed that both Y rearrangments are probably based on the similar sequence structure of proximal Yp and the distal AZFb region in Yq11.…”

Unilateral gonadal dysgenesis with both testis and fallopian tube on the same side in a 45,X/46,X INV (Y) mosaic male

“…The incidence of inverted Y chromosome in general population is 0.6-1 per 1,000 male births. No evidence existed regarding inverted Y (pl 1.2ql 1.23)chromosome associated with reproductive disadvantage and any phenotypic expression (Bernstein et al, 1986). However, in the case under study, ambiguous external genitalia and hypospadias might be due to mosaicism with 45,X cell line and correlates with previous report (Yanagisawa, 1980).…”

The Inverted Y-Chromosome Polymorphism in the Gujarati Muslim Indian Population of South Africa Has a Single Origin

“…An in verted Y chromosome was found at very high frequency (30.5%) in a Muslim Indian com munity living in the Johannesburg-Witwatersrand area of South Africa [1]. The high fre quency of the inv(Y) was presumed to have resulted from random genetic drift in a reproductively isolated community, main tained by strict endogamous marriage cus toms.…”

“…Inverted Y [inv(Y)] chromosomes have been observed in various cytogenetic popula tion studies [reviewed in 1], with an estimated incidence of 0.6 per 1,000 males [1]. An in verted Y chromosome was found at very high frequency (30.5%) in a Muslim Indian com munity living in the Johannesburg-Witwatersrand area of South Africa [1].…”

“…No reproductive disadvantages were as sociated with the inversion, and all the carriers of the inversion were Gujarati speakers whose families had migrated to South Africa from the Gujarati province of India during the early 1900s. Furthermore, the ancestors of the inv(Y) individuals were traced back to a small village, Kholvad, and some neighbouring vil lages, near the city of Surat [1], Torroni et al [6] did not include haplotypes 20-24 [5] in their list, thus the haplotype nomenclature is out of phase. Pvull haplotype nomenclature is described in Spurdle and Jenkins [7].…”