Inverted Urothelial Papilloma

Matz, L. R.; Wishart, Valerie A.; Goodman, M. A.

doi:10.3109/00313027409077154

Cited by 65 publications

(25 citation statements)

References 3 publications

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“…21,22 However, it is now recommended that the glandular variant of IUP should be considered florid cystitis cystica et glandularis. 23 IUP has also been described with vacuolated or foamy cytoplasm present either focally or diffusely. 8 These clear cells tend to be intermingled with the usual inverted papilloma cells.…”

Section: Morphology and Variantsmentioning

confidence: 99%

Inverted urothelial papilloma: A review of diagnostic pitfalls and clinical management

Sweeney

Rais‐Bahrami

Gordetsky

2017

CUAJ

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Inverted urothelial papilloma (IUP) is a rare, non-invasive endophytic lesion that accounts for 1-2% of urothelial tumours. On cystoscopy, IUP appears as a pedunculated/papillary mass with a smooth surface. On microscopy, IUP has an endophytic growth pattern with the bulk of the tumour covered by a superficial layer of urothelium, which can be hyperplastic or attenuated. The cytology should be bland, with uniform, spindled cells arranged in anastomosing trabeculae and cords with peripheral palisading of basaloid cells. Exophytic papillae and mitotic activity should be absent or focal. Pseudoglandular spaces and squamous metaplasia may also be present. There are distinct molecular differences between IUP and urothelial carcinoma (UC). IUP rarely has mutations of FGFR3, homozygous loss of 9p21, or gain of chromosomes 3, 7, and 17, whereas these mutations are frequently seen in UC. In addition, IUP is much less likely to have TERT mutations compared to UC. Immunohistochemistry can also be helpful in distinguishing the two entities as IUP is typically negative for CK20 and has a low Ki-67 proliferation index. Positivity for p53 may be seen in a minority of IUP. IUP can recur and be seen in association with UC.Distinguishing IUP from UC can be difficult due to the similarity between the two entities both on cystoscopy and histology, as up to 25% of UCs will also have inverted growth. Given the morphologic variants of IUP and UC, it is possible for a diagnostic error to occur, which can significantly impact patient management.

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Section: Morphology and Variantsmentioning

confidence: 99%

Inverted urothelial papilloma: A review of diagnostic pitfalls and clinical management

Sweeney

Rais‐Bahrami

Gordetsky

2017

CUAJ

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“…[30] considered the subtrigonal or subcer- vical glands as the tissue of origin. Matz et al [23] and Demester et al [10] believed that the von Brunn's nests could lead to the development of these papillomas by hyperplasia or neoplasia.…”

Section: Discussionmentioning

confidence: 99%

Inverted Papilloma of the Bladder

Aubert¹,

Doré²,

Touchard³

1984

Eur Urol

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“…More than 100 cases have been reported, mostly occurring in the bladder [5,14,17], Inverted papilloma of the upper urinary tract is even more unusual. There have been 5 reported cases occurring in the renal pelvis [2,11,12,16,17]. Of these, an inverted papilloma with malignant changes has been reported by Uyama and Moriwaki [16].…”

mentioning

confidence: 98%

“…The etiology of inverted papilloma of the ureter is unknown. According to some available data, the lesion originating in the bladder is thought to arise from chronic inflammatory stimula tion [6,10,11]. Matz et al [11] believe that the lesion represents hyperplasia of transitional epithelium.…”

mentioning

confidence: 99%