Inverted takotsubo cardiomyopathy in a patient with essential thrombocythemia exposed to anagrelide and phentermine

Dziewierz, Artur; Olszanecka, Agnieszka; Wiliński, Jerzy; Rakowski, Tomasz; Kleczyński, Paweł; Dubiel, Jacek S.; Dudek, Dariusz

doi:10.1016/j.ijcard.2012.01.045

Cited by 11 publications

(4 citation statements)

References 10 publications

(21 reference statements)

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“…There have been documented cases of cardiovascular adverse events with phentermine, like primary pulmonary hypertension [8], valvulopathy [9][10][11][12], restrictive cardiomyopathy [13], cerebral hemorrhage [14], ischemic stroke [15], supraventricular tachycardia [6], stress-induced cardiomyopathy [16,17], ventricular fibrillation [18], and polymorphic ventricular tachycardia [19]. Topiramate has not been shown to be associated with increased cardiovascular risk but may be associated with a range of metabolic effects [6,[9][10][11][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Dilated Cardiomyopathy: Beware of Diet Drugs Slimming the Heart

Bhattad¹,

Kumar²,

Dasari³

et al. 2023

Cureus

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There have been rare reports of dilated cardiomyopathy from chronic use of phentermine/topiramate, although very limited data are available. Phentermine is an atypical amphetamine analog that has been contraindicated in patients with a history of cardiovascular disease. We present a case of nonischemic dilated cardiomyopathy in the setting of chronic phentermine/topiramate use, which is the most likely cause of her dilated cardiomyopathy.

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Section: Discussionmentioning

confidence: 99%

Dilated Cardiomyopathy: Beware of Diet Drugs Slimming the Heart

Bhattad¹,

Kumar²,

Dasari³

et al. 2023

Cureus

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“…This case report describes a case of iatrogenic Takotsubo cardiomyopathy induced by combination sympathomimetic medications. Takotsubo cardiomyopathy was first described in the 1990s [ 1 ] , however, drug-induced disease is being increasingly reported [ 4 , 6 , 7 ] . While the precise aetiology of the condition is still unknown, it has been thought that overstimulation of the sympathetic nervous system causes increased contraction and ballooning of the ventricular myocardium [ 8 ] .…”

Section: Discussionmentioning

confidence: 99%

“…While isolated cases of monotherapy or combination stimulants causing TC are described in the literature [ 7 , 9 , 10 ] , the combination of lisdexamfetamine and phentermine causing TC has not been previously reported in the published literature.…”

Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy Due to Combined Use of Phentermine and Lisdexamfetamine

Burleigh

Birgit

2020

European Journal of Case Reports in Internal Medicine

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Objectives: This is the first case report of iatrogenic Takotsubo syndrome (TS) due to a combination of lisdexamfetamine and phentermine. Background: TS is characterized by transient acute ballooning of the left ventricular wall. Typically, it occurs in extremely stressed post-menopausal women, however a few iatrogenic causes have been described recently. Results: A 55-year old woman prescribed lisdexamfetamine and phentermine, presented with acute substernal chest pain. Acute coronary syndrome was excluded. The echocardiogram was diagnostic of TS, and she recovered spontaneously, with supportive care. Conclusion: Caution with the use of sympathomimetic medications in post-menopausal women appears warranted.

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“…87 Phentermine is an amphetamine derivative used as an appetite suppressant, which is thought to be a sympathomimetic amines that stimulate the release of norepinephrine and dopamine from the storage sites in the presynaptic nerve terminals. 119 Other catecholamine-related causes included indirect adrenergic effects, including parasympathetic block (2 cases), 117,122 sudden withdrawal of b-blockers (3 cases), 76,77 anaphylactic reactions (5 cases), [81][82][83][84]118 withdrawal of opioids (5 cases), 69,70,75,78,79 or alcohol (2 cases). 71,125 Opioid withdrawal is known to cause hyperadrenergic state that leads to catecholamine surge and increased b-receptor sensitivity and subsequently myocardial stunning.…”

Section: Discussionmentioning

confidence: 99%