Inverted Papilloma: Considerations in Treatment

Ge, Woodson; Kt, Robbins; Michaels, L.

doi:10.1001/archotol.1985.00800140050009

Cited by 69 publications

(37 citation statements)

References 8 publications

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“…Patients with inverted papilloma should undergo thorough surgery to remove the whole mucosal disease, most probably by the endoscopic, endonasal route when complete resection is possible [386, 402–404]. The whole tissue should be inspected for possible malignancy [90, 405]. The pathological examination of surgical margin could partially judge the prognosis [406].…”

Section: Treatmentmentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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Skull base inverted papilloma (IP) is an unusual entity for many neurosurgeons. IP is renowned for its high rate of recurrence, its ability to cause local destruction, and its association with malignancy. This paper is a comprehensive review of the reports, studies, and reviews published in the current biomedical literature from 1947 to September 2010 and synthesize this information to focus on its potential invasion to the base of the skull and possible intradural extension. The objective is to familiarize the clinician with the different aspects of this unusual disease. The role of modern diagnostic tools in medical imaging in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The treatment guidelines for IP have undergone a complex evolution that continues today. Radical excision of the tumour is technically difficult and often incomplete. Successful management of IP requires resection of the affected mucosa which could be achieved with open surgery, endoscopic, or combined approach. Radio and chemotherapy were used for certain indications. More optimally research would be a multicenter randomized trials with large size cohorts.

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Section: Treatmentmentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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“…In published studies, the incidence of SCC associated with SIP has varied substantially. Woodson and c o w o r k e r s 8 reported an incidence of less than 2% of SCCs arising in SIP; Phillips and coworkers 9 reported a 7% incidence in 112 patients; and Bielamowicz et al 10 more recently reported a 17% cancer incidence in SIP.…”

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confidence: 98%

CD44 Expression in Sinonasal Inverted Papillomas and Associated Squamous Cell Carcinoma

et al. 1998

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Increased expression of the cell adhesion molecule, CD44 standard form (CD44s), has been associated with papillary epithelial tumors, and decreased expression has been linked to tumor invasion and metastasis. Sinonasal inverted papillomas (SIPs) are the most common papillary tumors of the sinonasal tract. This study tests whether the development of squamous cell carcinoma (SCO in situ and invasive SCC in SIP is associated with altered expression of CD44s.Seventy-six specimens of SIP from 68 patients, 2 specimens of SIP with focal SCC in situ, and 10 specimens of invasive SCC arising in SIP were studied. Automated immunohistochemistry was performed for CD44s expression on paraffin-embedded tissue sections using mouse antihuman CD44 antibody.All 76 SIPs (100%) expressed CD44 (strong membranous staining, 83%; moderate staining, 12%; weak staining, 5%). TwoThe inverted papilloma is the most frequent benign mucosal neoplasm of the sinonasal tract.1-7 Sinonasal inverted papillomas (SIPs) are derived from the Schneiderian epithelium and occur most frequently during the fourth and fifth decades of life, with a male/female incidence ratio of 2:1.1 _ 6 Most commonly, SIP manifests as a unilateral nasal obstruction and features multiple mucosal sites of origin, reflecting a diffuse polypoid change of the nasal and paranasal sinus mucosa.6 Histologic features of SIP include squamous metaplasia of surface gland ducts and, frequently, branching gland ducts; stromal edema with infiltrates of lymphocytes, eosinophils, plasma cells, and m a c r o p h a g e s ; and n u m e r o u s macrophage-rich microcysts containing fragments of degenerated nuclear material.6 Although histologically benign, SIP features a substantial rate of recurrence after initial resection, which has varied from 33% to 74% in the published literature. [1][2][3][4][5][6] Squamous cell carcinoma (SCC) has been frequently associated with SIP since the first description by Hapman and Billroth in 1883/ Squamous cell carcinoma may be identified in the original excision of SIP or develop months or years after the first SIP excision, with roughly equal frequency. In published studies, the incidence of SCC associated with SIP has varied substantially. Woodson and c o w o r k e r s 8 reported an incidence of less than 2% of SCCs arising in SIP; Phillips and coworkers 9 reported a 7% incidence in 112 patients; and Bielamowicz et al 10 more recently reported a 17% cancer incidence in SIP.Cell adhesion molecules have been studied in a variety of papillary and nonpapillary epithelial neoplasms. CD44 is a polymorphic integral glycosylated cartilage link protein associated with cell matrix adhesion, lymphocyte activation and recirculation, and cell 309

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“…When conservative intranasal procedures such as polypectomy, antrostomy, and internal ethmoidectomy are the selected treatment approaches, a 76% or greater recurrence rate may be expected. 6 With conservative external procedures such as Caldwell-Luc, transantral ethmoidectomy, or external ethmoidectomy alone, recurrence developed in 43% of patients in the Woodson series. With lateral rhinotomy and medial maxillectomy, the rate of recurrence can be lowered to almost Thus, the lateral rhinotomy has become the accepted surgical method for definitive management of inverted papilloma.…”

Section: Discussionmentioning

confidence: 99%

The Septal Translocation Procedure: An Alternative to Lateral Rhinotomy

Sofferman

1988

Otolaryngol.--head neck surg.

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Lesions deep in the nasal vault with contiguous sinus involvement often required a lateral rhinotomy for exposure. This procedure affords excellent surgical access, but requires a significant external incision. An alternative sublabial technique, with dislocation of the nasal septum into the opposite nasal passage, provides excellent surgical exposure for these same lesions, while external facial incisions are avoided. The text outlines the surgical technique and representative uses in optic nerve decompression, inverted papilloma, giant rhinolith, angiofibroma, and a variety of nasosinus and nasopharyngeal malignant lesions.

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Inverted Papilloma: Considerations in Treatment

Cited by 69 publications

References 8 publications

Skull Base Inverted Papilloma: A Comprehensive Review

Skull Base Inverted Papilloma: A Comprehensive Review

CD44 Expression in Sinonasal Inverted Papillomas and Associated Squamous Cell Carcinoma

The Septal Translocation Procedure: An Alternative to Lateral Rhinotomy

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