Invertebrates differentially bioaccumulate pharmaceuticals: Implications for routine biomonitoring

Grabicová, Kateřina; Staňová, Andrea Vojs; Švecová, Helena; Nováková, Petra; Kodeš, Vít; Leontovycova, Drahomira; Brooks, Bryan W.; Grabic, Roman

doi:10.1016/j.envpol.2022.119715

Cited by 9 publications

(9 citation statements)

References 43 publications

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“…In addition, usually the samples were freeze-dried, so that spraying in the absence of humidity would be easier, although several studies worked with wet weight [ 50 , 79 ]. In case of molluscs, cephalopods or crustaceans were generally pooled without differentiating body cavities, removed from the shell if present, freeze-dried and ground into powder [ 34 , 60 , 68 ]. Ojemaye and Petrick [ 36 ], for the study of algae and echinoderms, rinsed, shelled and dissected by freeze-drying, and in the case of plankton, they were washed, homogenized and stored at −20 °C [ 37 , 62 ].…”

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

“…Rojo et al [ 52 ] studied different families of PhACs in fish muscle tissue, achieving recoveries between 26 and 115%. Other authors have proposed this technique to investigated different drugs in several types of fish as well as biofilm, plankton, bivalves, crustaceans and cephalopods obtaining LODs between 0.0004 and 6 ng g −1 and recoveries ranging from 20 to 151% [ 26 , 34 , 39 , 47 , 75 , 86 ].…”

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

“…However, although these organisms have often been used as bioindicators of marine pollution, pharmaceutical bioaccumulation is poorly developed, and the presence of these compounds in benthic species differs between sampling sites. Some authors have proposed the used of caged organisms rather than in wild ones, as it varies between species and the distribution and abundance of these specimens’ changes spatially and temporally [ 34 ]. In the literature, the most studied molluscs were bivalves, specifically mussels, but also oysters, clams, limpets and sea snails [ 35 , 36 , 37 ].…”

Section: Multi-level Biological Groups As Biomarkers Of Exposurementioning

confidence: 99%

“…Biomonitoring of these species is important due to human consumption, as they are a higher link in the food chain and, besides the inhalation exposure, the presence of contaminants in their bodies may be due to biomagnification (dietary exposure). Human exposure is the main reason to study the bioaccumulation of PhACs in different fish species as well as other biota across trophic levels [ 34 ]. Among the different fish species ussually used in bioaccumulation studies are carp [ 38 ], flatfish [ 43 ], salmon and rainbow trout [ 46 ] or mullet [ 47 , 48 ].…”

Section: Multi-level Biological Groups As Biomarkers Of Exposurementioning

confidence: 99%

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An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

et al. 2022

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There is increasing scientific evidence that some pharmaceuticals are present in the marine ecosystems at concentrations that may cause adverse effects on the organisms that inhabit them. At present, there is still very little scientific literature on the (bio)accumulation of these compounds in different species, let alone on the relationship between the presence of these compounds and the adverse effects they produce. However, attempts have been made to optimize and validate analytical methods for the determination of residues of pharmaceuticals in marine biota by studying the stages of sample treatment, sample clean-up and subsequent analysis. The proposed bibliographic review includes a summary of the most commonly techniques, and its analytical features, proposed to determine pharmaceutical compounds in aquatic organisms at different levels of the trophic chain in the last 10 years.

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Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

Section: Multi-level Biological Groups As Biomarkers Of Exposurementioning

confidence: 99%

Section: Multi-level Biological Groups As Biomarkers Of Exposurementioning

confidence: 99%

See 2 more Smart Citations

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

et al. 2022

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“…Besides monitoring microbes and developing the technologies needed to undertake more effective monitoring, Grabicová et al (2022) and other researchers conducted studies on the continuous tracking of chemicals in water and the environment, including drugs and pesticide residuals. Periolatto et al (2022) examined the subject of routine monitoring of traces of arsenic in water; while Ezzaouini et al (2022) applied machine learning to assess levels of suspended sediments.…”

Section: Introductionmentioning

confidence: 99%

The Role of Routine Programme for Monitoring and Evaluation on Sub-national Water Services in Kenya

Motari¹,

Rambo²,

Nyonje³

2022

JSD

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Routine programme for monitoring and evaluation involves data gathering, analysis and reporting to ensure progress and ultimately achievement of project goals. This study determined the influence of routine programme for monitoring and evaluation on sub-national water services in Nyamira South Sub County, Kenya. A mixed method, cross-sectional and correlational design was used. Study findings were generated using quantitative interviews from a total of 480 household heads; and staff from the local water services company. Qualitative information was generated from discussions with 40 village elders. The study established that provision of water services in the study area was not sustainable, with only about 23 percent of households accessing water services. The study findings also revealed poor monitoring of the water services. However, the findings demonstrated a linear, positive, and significant association between routine programme for monitoring and evaluation and sustainability of water services. The Pearson correlation coefficient was 0.724 and p-values were 0.000 for both correlation and regression analyses. The findings support the strengthening of routine programme for monitoring and evaluation as a way of reinforcing the long-term management of water resources at sub-national level.

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Developing an Approach for Integrating Chemical Analysis and Transcriptional Changes to Assess Contaminants in Water, Sediment, and Fish

Cardenas Perez,

Challis,

Alcaraz

et al. 2024

Enviro Toxic and Chemistry

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Pharmaceuticals in aquatic environments pose threats to aquatic organisms because of their continuous release and potential accumulation. Monitoring methods for these contaminants are inadequate, with targeted analyses falling short in assessing water quality's impact on biota. The present study advocates for integrated strategies combining suspect and targeted chemical analyses with molecular biomarker approaches to better understand the risks posed by complex chemical mixtures to nontarget organisms. The research aimed to integrate chemical analysis and transcriptome changes in fathead minnows to prioritize contaminants, assess their effects, and apply this strategy in Wascana Creek, Canada. Analysis revealed higher pharmaceutical concentrations downstream of a wastewater‐treatment plant, with clozapine being the most abundant in fathead minnows, showing notable bioavailability from water and sediment sources. Considering the importance of bioaccumulation factor and biota–sediment accumulation factor in risk assessment, these coefficients were calculated based on field data collected during spring, summer, and fall seasons in 2021. Bioaccumulation was classified as very bioaccumulative with values >5000 L kg–1, suggesting the ability of pharmaceuticals to accumulate in aquatic organisms. The study highlighted the intricate relationship between nutrient availability, water quality, and key pathways affected by pharmaceuticals, personal care products, and rubber components. Prioritization of these chemicals was done through suspect analysis, supported by identifying perturbed pathways (specifically signaling and cellular processes) using transcriptomic analysis in exposed fish. This strategy not only aids in environmental risk assessment but also serves as a practical model for other watersheds, streamlining risk‐assessment processes to identify environmental hazards and work toward reducing risks from contaminants of emerging concern. Environ Toxicol Chem 2024;00:1–22. © 2024 SETAC

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Invertebrates differentially bioaccumulate pharmaceuticals: Implications for routine biomonitoring

Cited by 9 publications

References 43 publications

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

The Role of Routine Programme for Monitoring and Evaluation on Sub-national Water Services in Kenya

Developing an Approach for Integrating Chemical Analysis and Transcriptional Changes to Assess Contaminants in Water, Sediment, and Fish

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