Inversions and integrations using CRISPR/Cas9 and a module-based plasmid construction kit for fission yeast
Cristina Berenguer Millanes,
Bart P.S. Nieuwenhuis
Abstract:Structural variants (SV) are genetic alterations that involve large-scale changes in the structure of a genome. These variations can encompass deletions, duplications, inversions, translocations, or complex rearrangements. While smaller structural variants are relatively well studied, much is unknown about the prevalence and effect of larger SV. Genome sequencing methods that are able to find large reorganization in the genome, e.g. using mate pair or long-reads, have shown inversions and translocations are mo… Show more
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