Inversion of levels of human T and B cells in early pregnancy

Aj, Strelkauskas; Bs, Wilson; Dray, Danielle; Dodson, Melvin G.

doi:10.1038/258331a0

Cited by 70 publications

(15 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have indicated that hCG changes the cellmediated and humoral immune response to the stimulus of cancer antigens (Contractor & Davies, 1973;Fabris et al, 1977;Strelkauskas et al, 1975). McManus et al (1976) suggested that the presence of hCG on the tumour surface would suppress the action of the patient's T-cells, thereby favouring high proliferative activity and local invasions.…”

Section: Discussionmentioning

confidence: 99%

Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis

Yamaguchi

Ishida²,

Nishimura³

et al. 1989

Br J Cancer

View full text Add to dashboard Cite

Summary The presence of human chorionic gonadotropin in large bowel cancers was studied immunohistochemically using an immunoperoxidase technique. HCG-positive tumour cells were present in 42 of 194 adenocarcinomas examined (22.0% of colon cancer and 21.2% of rectal cancers). On histological grading, the hCG-positive rate tended to rise as the degree of differentiation decreased. HCG was detected more frequently in cancers invading the total bowel wall (27%) than in those invading the partial wall (17.1%). Lymph node, liver or peritoneal metastases were present more frequently in hCG-positive tumours than in hCG-negative tumours. Furthermore, there was an intimate correlation between the presence of hCG-positive tumour cells and CEA doubling times in nine cases with untreated liver metastasis. The survival rate for patients with tissue hCG-positive cells was lower than for those with hCG-negative tumours. Thus, the presence of tissue hCG in colorectal cancers may be a biological marker of prognostic significance.

show abstract

Section: Discussionmentioning

confidence: 99%

Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis

Yamaguchi

Ishida²,

Nishimura³

et al. 1989

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…The time interval between the onset of the disease and the time the blood sample was taken varied between a few weeks (4-6 weeks) and 16 years. The mode of onset was systemic in 3, monoarticular in 9, and pauci or polyarticular in 18 G-200 anti-F(ab')2 affinity column chromatography (16) or by negative selection through Ficoll using chromium chloride-treated sheep erythrocytes coupled with purified rabbit anti-human immunoglobulin (17).…”

mentioning

confidence: 99%

Direct evidence for loss of human suppressor cells during active autoimmune disease.

Strelkauskas¹,

Callery²,

McDowell³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

147

View full text Add to dashboard Cite

These studies indicate that a regulatory subset of Iym0hocytes is missing in patients with juvenile rheumatoid arthritis but these patients have antibodies in their serum that react with normal T cells. This regulatory subset of T cells is, however, present in patients whose serum shows little or no reactivity with normal T cells. In addition, patients who are deficient in this regulatory subset of lymphocytes have siguificantly higher numbers of cells secreting Ig as measured by a hemolrtic plaque assay. The significance of these observations old: first, they represent a positive relationship among the loss of regulation, overproduction of immunoglobulin, and the presence of anti-T cell antibodies; and second, and perhaps of equal importance, is the indication that serum from patients with autoimmune diseases may give us a readil av'table reagent with which to dissect further functionally distinct subsets of normal T cells in man. Recent progress in murine systems has demonstrated that both the type and the intensity of the cellular and humoral immune responses can be regulated by a complex series of cellular interactions involving distinct subsets of lymphocytes (1)(2)(3). It has been shown that antigen triggers subpopulations of T lymphocytes capable of helping, amplifying, or suppressing other T-cell or B-cell responses (4, 5). The human T cell, like its counterpart in the mouse, expresses in vitro various functions including proliferation. in response to soluble and cell surface antigens, elaboration of mediators, activation by polyclonal mitogens, and cytotoxic activities (6). In man, it is now clear that regulatory T cells exist and can be defined by their functional properties in both normal (7-9) and pathologic states (10, 11). More recent data support the notion that T-cell help and suppression are mediated by different subpopulations of T cells bearing distinct Fc receptors (12) and cell surface antigens as defined by allo-and heteroantisera (13,14).We have previously shown that sera from four patients with juvenile rheumatoid arthritis (JRA) Patients. Records of all children who have attended the arthritis clinic at the Children's Hospital (Boston, MA) were reviewed. Only those children for whom a positive diagnosis of JRA was confirmed were included in the study (15). There were 30 children with this diagnosis. They were between 3 and 19 years of age and included 5 boys and 25 girls. The time interval between the onset of the disease and the time the blood sample was taken varied between a few weeks (4-6 weeks) and 16 years. The mode of onset was systemic in 3, monoarticular in 9, and pauci or polyarticular in 18. The criteria for classification as active disease or remission were based on objective findings by physical examination alone. Thus, children with at least one swollen joint were considered to have active disease, whether or not they had other physical abnormalities such as limitation of motion, signs of synovitis, or joint deformities. Patients in remission had normal results o...

show abstract

“…It does not seem likely that the heterologous nature of HCG to murine lymphocytes is responsible to this enhancement of the PFC, since human serum albumin did not influence this count in our system. Strelkauskas et al (1975) showed that the ratio of human T to B cells was inverted in early pregnancy. This increase in the B cell level may parallel the HCG rise at this period.…”

Section: Resultsmentioning

confidence: 99%

The effect of various hormones on the humoral immune response of murine lymphocytes in vitro.

Okamura

Kuramoto

Hamazaki

et al. 1978

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Inversion of levels of human T and B cells in early pregnancy

Cited by 70 publications

References 17 publications

Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis

Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis

Direct evidence for loss of human suppressor cells during active autoimmune disease.

The effect of various hormones on the humoral immune response of murine lymphocytes in vitro.

Contact Info

Product

Resources

About