Inversin‐deficient (inv) mice do not establish a polarized duct system in the liver and pancreas
Hiromu Fujisawa,
Noriaki Ota,
Nobuyoshi Shiojiri
Abstract:Inversin‐deficient (inv) mice have anomalies in liver and pancreatic development in addition to an inverted left–right axis of the body. The present study was undertaken to unveil mechanisms of bile and pancreatic duct development from immunohistochemical analyses of anomalies in inv mice. Intrahepatic bile ducts having proximodistal polarity in size and the height of their epithelia, and ductules were formed in livers of wild‐type neonates. By contrast, in inv mice, ductal plates, precursor structures of intr… Show more
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