Inverse U-shaped Association between Sleep Duration and Semen Quality: Longitudinal Observational Study (MARHCS) in Chongqing, China

Chen, Qing; Yang, Huan; Zhou, Nina; Sun, Lei; Bao, Huaqiong; Tan, Lu; Chen, Hongqiang; Liu, Xi; Zhang, Guowei; Huang, Linping; Li, Lianbing; Ma, Mingfu; Yang, Hsiao-Ching; Wang, Xiaogang; Zou, Peng; Peng, Kaige; Liu, Taixiu; Cui, Zhihong; Ao, Lin; Roenneberg, Till; Zhou, Ziyuan; Cao, Jia

doi:10.5665/sleep.5322

Cited by 92 publications

(78 citation statements)

References 34 publications

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“…Kim et al 2016, Niijima et al 2016); however, it is different to the ones reported for some other pathologies where a U-shaped (e.g. Li et al 2015, Chen et al 2016 or an inverse linear association was reported (e.g. King et al 2008).…”

Section: Interpretation In the Context Of Available Literaturecontrasting

confidence: 62%

The association between periodontitis and sleep duration

Romandini

Gioco

Perfetti

et al. 2017

J Clinic Periodontology

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Section: Interpretation In the Context Of Available Literaturecontrasting

confidence: 62%

The association between periodontitis and sleep duration

Romandini

Gioco

Perfetti

et al. 2017

J Clinic Periodontology

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“…Regular and adequate sleep is important for normal physiology, but its role in human semen quality is not clear. In a longitudinal study, the investigators suggested that both restricted and excessive sleep had negative impact on semen quality (Chen et al, ; Liu et al, ). Sleep duration was not associated with any of the semen parameters in our study.…”

Section: Discussionmentioning

confidence: 99%

The impact of sociodemographic characteristics, lifestyle, work exposure and medical history on semen parameters in young Chinese men: A cross‐sectional study

et al. 2019

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There is an ongoing debate on the declining semen quality, and unfortunately, existing evidence is inconclusive and inconsistence. We evaluated the impact of sociodemographic characteristics, lifestyle, medical history and work exposure on semen quality. Univariate and multivariate analysis was used to investigate the association between different risk factors and semen quality parameters. Total sperm count (p = 0.041), sperm concentration (p = 0.007), normal morphology (p = 0.002), total motility (p = 0.004) and progressive motility (p = 0.009) decreased in men with varicocele. Sperm concentration increased in tea (p = 0.044); progressive and total motility increased in cola (p = 0.018, p = 0.012) consumers. Progressive and total motility decreased in urogenital surgery (p = 0.016, p = 0.014) and infection (p = 0.037, p = 0.022). However, age, coffee and alcohol drinking, physical activities, sleep duration and cell phone use were unrelated to any of semen parameters. Interestingly, semen volume (p < 0.0001), total sperm count (p < 0.0001) and concentration (p < 0.033) increased with longer abstinence period (>5 days); normal morphology (p = 0.013) improved in men with higher body mass index (BMI > 24), curvilinear velocity (p = 0.042) increased with smoking; semen volume (p = 0.050) increased in manual labourers. This study highlights the importance of sociodemographic characteristics, lifestyle, occupational exposure and medical history and provides time trends in semen quality, its clinical importance and direction for further research.

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“…These include increased risk of cardio-metabolic complications, hypertension, obesity, type 2-diabetes, cardiovascular disease, urologic complications, cancer, and depression [1][2][3][4][5][6]. Results from a limited number of recent studies suggest that inadequate bedtimes, short sleep duration, and poor sleep, assessed as poor self-reported sleep quality, may impact semen quality [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Sleep duration itself has been linked to semen quality in fertile [9] and in infertile [13,14] men. Chen et al [9] found the optimal sleep duration to be 7.0-7.5 h in 796 Chinese fertile men. Green et al [14] found a positive correlation between sleep duration and total sperm and motility.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, only three studies have used validated self-report questionnaires or subscales to measure sleep quality in association with semen quality. Chen et al [9] found an association between Pittsburgh Sleep Quality Index (PSQI) global scores [15] and semen parameters (volume and total sperm number) in a study of 656 fertile Chinese men. Jensen et al [10] found an inverse u-shaped relationship between sleep quality and semen quality using a modified 4-item version of the Karolinska Sleep Questionnaire [16] in a sample of 953 fertile Danish men.…”

Section: Introductionmentioning

confidence: 99%

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Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study

Hvidt

Knudsen

Zachariae

et al. 2020

Basic Clin. Androl.

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Background: Poor sleep has been linked to a number of adverse health outcomes. Recent studies suggest that late bedtimes, short or long sleep durations, and poor sleep quality may impair semen quality. No study has previously explored all three factors in relation to semen quality. Results: One hundred and four men and their partners treated at three fertility clinics in Denmark between 2010 and 2012 completed an online-version of the Pittsburgh Sleep Quality Index (PSQI). The results of the semen analyses conducted at the fertility clinics were self-reported and categorised as normal or reduced. Early bedtime (< 10:30 PM) was more often associated with normal semen quality compared with both regular (10:30 PM-11:29 PM) and late (≥11:30 PM) bedtime (OR: 2.75, 95%CI: 1.1-7.1, p = 0.04 and OR: 3.97, 95%CI: 1.2-13.5, p = 0.03). Conventional sleep duration (7.5-7.99 h) was more often associated with normal semen quality than both short (7.0-7.49 h) and very short (< 7.0 h) sleep duration (OR: 1.36, 95% CI: 1.2-12.9, p = 0.03 and OR: 6.18, 95%CI: 1.6-24.2, p = 0.01). Although poor sleep quality was associated with reduced semen quality in the descriptive statistics (p = 0.04), no differences were found between optimal (PSQI ≤6) and either borderline (PSQI 7-8) or poor (PSQI ≥9) sleep quality (OR: 1.19, 95%CI: 0.4-3.4, p = 0.75 and OR: 2.43, 95%CI: 0.8-7.1, p = 0.11) in multivariate regression models. Conclusion: Early bedtimes (< 10:30 PM) and conventional sleep duration (7.5-7.99 h) were associated with selfreported normal semen quality. The role of subjective sleep quality remains uncertain.

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Inverse U-shaped Association between Sleep Duration and Semen Quality: Longitudinal Observational Study (MARHCS) in Chongqing, China

Abstract: Either restricted or excessive sleep may impair semen quality. Further research is needed to validate this finding.

Cited by 92 publications

References 34 publications

The association between periodontitis and sleep duration

The association between periodontitis and sleep duration

The impact of sociodemographic characteristics, lifestyle, work exposure and medical history on semen parameters in young Chinese men: A cross‐sectional study

Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study

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