Inverse relationship between total testosterone and anti-oxidized low density lipoprotein antibody levels in ageing males

Barud, Wojciech; Palusiński, Robert; Bełtowski, Jerzy; Wójcicka, Grażyna

doi:10.1016/s0021-9150(02)00069-2

Cited by 49 publications

(34 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pathophysiology of cardiovascular risk of low testosterone serum level may be related to increased fat mass (14). A host of previous studies have suggested that reduced testosterone levels were associated with increased total cholesterol and LDL-c (15)(16)(17), and increased TG and reduced HDL-c (18). In other studies, the systolic and diastolic blood pressures have been shown to be inversely correlated with testosterone level (19).…”

Section: Discussionmentioning

confidence: 98%

Does the Serum Testosterone Level has a Relation to Coronary Artery Disease in Elderly Men?

2013

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Does the Serum Testosterone Level has a Relation to Coronary Artery Disease in Elderly Men?

2013

View full text Add to dashboard Cite

show abstract

“…In women, it is well known that hyperandrogenism is often associated with increased intra-abdominal fat accumulation and the metabolic syndrome (as for the case of polycystic ovary syndrome; Gambineri et al 2009), and the decline of estrogen after menopause is known to determine an increase in intraabdominal fat mass (Lobo 2008). In men, testosterone deficiency in hypogonadic individuals is associated with a significant change in body composition (especially featured by an increase in fat mass) and with the frequent presence of dysmetabolisms (Barrett-Connor 1992, Barud et al 2002, Grossmann et al 2010, Traish et al 2011. Testosterone replacement therapy in patients with reduced testosterone levels has been shown to produce a significant metabolic amelioration, not only related to body weight but also related to the glucose and lipid profile (Traish et al 2011).…”

Section: Brown Adipose Tissue and Obesitymentioning

confidence: 99%

Role of sex hormones in modulation of brown adipose tissue activity

Quarta

Mazza²,

Pasquali³

et al. 2012

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

The recent demonstration that metabolically active brown adipose tissue (BAT) is present with a high prevalence in humans undoubtedly represents one of the major advancements in the field of metabolic research in the last few years. The increasing interest in BAT is justified by preclinical observations highlighting an important role of this tissue in energy dissipation and metabolic clearance of substrates from the blood. These findings imply that stimulation of BAT activity may represent a new therapeutic approach for obesity and associated comorbidities. However, before proposing BAT as a target organ for therapeutics in a clinical setting, many further notions about BAT function and modulation need to be explored. Keeping in mind the importance of sex dimorphism in energy metabolism control under physiological and pathological conditions, sex hormones may play a relevant role in the regulation of BAT activity in both males and females. Much of the evidence acquired in the past supports the concept of an important role for different sex hormones in BAT thermogenesis and indicates that this tissue mediates the ability of sex hormones to modulate energy balance. These findings make it plausible that a modified interaction between BAT and sex hormones may contribute to the development and the maintenance of obesity and associated metabolic complications.Journal of Molecular Endocrinology (2012) 49, R1-R7

show abstract

“…DHEA-S levels have a negative correlation with triglyceride and total cholesterol levels, and a positive correlation with HDL level [20]. On the other hand, the existence of a significant correlation has not been determined in many studies [19][20][21]. High androgen levels seem to be correlated with desired lipid profile for males [22].…”

Section: Discussionmentioning

confidence: 97%

“…Testosterone is inversely related to the levels of total cholesterol, LDL, triglyceride and lipoprotein (a) while it is directly related to HDL. These correlations have created a risk for the occurrence of ischaemic CAD [19]. The relationship between DHEA-S and lipid levels is considered to be conflicting.…”

Section: Discussionmentioning

confidence: 99%