Inverse Relationship Between Physical Activity and Arterial Stiffness in Adults With Hypertension

O’Donovan, C.; Lithander, Fiona E; Raftery, Tara; Gormley, John; Mahmud, Azra; Hussey, Juliette

doi:10.1123/jpah.2012-0075

Cited by 51 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is current evidence of the beneficial effects of moderate physical activity on the arterial stiffness and on overall clinical outcomes of patients with hypertension [17]. Only 40 % of the participants in this study reported performing some type of physical activity when their blood pressure readings were high.…”

Section: Discussionmentioning

confidence: 65%

“…The acute effect of physical activity on blood pressure readings is also important. It was found that a single bout of aerobic exercise reduced 24 h ambulatory blood pressure levels in long-term-treated hypertensive patients and increased the percentage of patients reaching normal ambulatory blood pressure values [17]. Aerobic exercise also has a potential role in blood pressure management of long-term-treated hypertensive both in active and sedentary obese hypertensive patients [18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Home monitoring of blood pressure: patients’ perception and role of the pharmacist

Basheti¹,

Khdair²

2014

Trop. J. Pharm Res

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Home monitoring of blood pressure: patients’ perception and role of the pharmacist

Basheti¹,

Khdair²

2014

Trop. J. Pharm Res

View full text Add to dashboard Cite

“…Moreover, in older patients with type 2 diabetes and hypertension, a focus on increasing step counts may be a more realistic and practical option than increasing intensity, as suggested by evaluations of patient preferences [38]. Consistent with this, previous evidence suggests that even habitual physical activity is associated with decreased arterial stiffness [37,39–41]. Several changes in arterial structure with aging or presence of cardiovascular risk factors may contribute to increased arterial stiffness, including fragmentation of elastin, deposition of collagen, and smooth muscle hypertrophy as a result of exposure to free radicals and inflammatory cytokines [42], and also reduced nitric oxide and increased vasoconstrictors (angiotensin, endothelin, prostaglandins) [43].…”

Section: Discussionmentioning

confidence: 87%

Carotid femoral pulse wave velocity in type 2 diabetes and hypertension

Dasgupta

Rosenberg²,

Joseph³

et al. 2017

Journal of Hypertension

View full text Add to dashboard Cite

Objective:Optimal medication use obscures the impact of physical activity on traditional cardiometabolic risk factors. We evaluated the relationship between step counts and carotid-femoral pulse wave velocity (cfPWV), a summative risk indicator, in patients with type 2 diabetes and/or hypertension.Research design and methods:Three hundred and sixty-nine participants were recruited (outpatient clinics; Montreal, Quebec; 2011–2015). Physical activity (pedometer/accelerometer), cfPWV (applanation tonometry), and risk factors (A1C, Homeostatic Model Assessment–Insulin Resistance, blood pressure, lipid profiles) were evaluated. Linear regression models were constructed to quantify the relationship of steps/day with cfPWV.Results:The study population comprised 191 patients with type 2 diabetes and hypertension, 39 with type 2 diabetes, and 139 with hypertension (mean ± SD: age 59.6 ± 11.2 years; BMI 31.3 ± 4.8 kg/m2; 54.2% women). Blood pressure (125/77 ± 15/9 mmHg), A1C (diabetes: 7.7 ± 1.3%; 61 mmol/mol), and low-density lipoprotein cholesterol (diabetes: 2.19 ± 0.8 mmol/l; without diabetes: 3.13 ± 1.1mmol/l) were close to target. Participants averaged 5125 ± 2722 steps/day. Mean cfPWV was 9.8 ± 2.2 m/s. Steps correlated with cfPWV, but not with other risk factors. A 1000 steps/day increment was associated with a 0.1 m/s cfPWV decrement across adjusted models and in subgroup analysis by diabetes status. In a model adjusted for age, sex, BMI, ethnicity, immigrant status, employment, education, diabetes, hypertension, medication classes, the mean cfPWV decrement was 0.11 m/s (95% confidence interval −0.2, −0.02).Conclusions:cfPWV is responsive to step counts in patients who are well controlled on cardioprotective medications. This ability to capture the ‘added value’ of physical activity supports the emerging role of cfPWV in arterial health monitoring.

show abstract

“…Weight loss has been shown to reduce cardiovascular risk factors including arterial stiffness 11–13 . In addition, physically inactive individuals have been shown to have stiffer arterial vessels than physically active individuals 14, 15 .…”

Section: Introductionmentioning

confidence: 99%

The impact of change in physical activity on change in arterial stiffness in overweight or obese sedentary young adults

et al. 2014

View full text Add to dashboard Cite

Arterial stiffness is associated with cardiovascular events and mortality. Lifestyle factors such as physical activity may reduce arterial stiffness. The purpose of this study is to determine the impact of change in physical activity (PA) on one-year change in arterial stiffness in 274 overweight/obese sedentary young adults. The Slow Adverse Vascular Effects of excess weight (SAVE) trial was a study evaluating the relationships between weight loss, dietary sodium, and vascular health. PA was measured with the ActiGraph AM7164 accelerometer. Intensity of activity was determined using established cutpoints. Arterial stiffness was assessed by brachial-ankle PWV (baPWV) using an automated device. Analysis of Covariance compared changes in total accelerometer counts, minutes/day in light intensity PA (LPA), and moderate-to-vigorous PA (MVPA), and sedentary time, by categories of change in baPWV. Models were adjusted for time since baseline visit, age, sex, race, homeostatis model of assessment of insulin resistance, mean arterial pressure, heart rate, and weight change. Total accelerometer counts and time spent in MVPA increased from baseline to 12 months while time spent in LPA significantly decreased. Mean baPWV was similar at each time point. Those that showed decreased baPWV also showed an increase in total accelerometer counts per day and time spent in MVPA in the fully adjusted models (p<0.001). Changes in sedentary time and time spent in LPA were not associated with changes in baPWV. These results indicate that even modest increases in MVPA can reduce arterial stiffness, a risk factor for future cardiovascular events.

show abstract

Inverse Relationship Between Physical Activity and Arterial Stiffness in Adults With Hypertension

Abstract: Habitual physical activity of all intensities is associated with reduced arterial stiffness among adults with hypertension.

Cited by 51 publications

References 0 publications

Home monitoring of blood pressure: patients’ perception and role of the pharmacist

Home monitoring of blood pressure: patients’ perception and role of the pharmacist

Carotid femoral pulse wave velocity in type 2 diabetes and hypertension

The impact of change in physical activity on change in arterial stiffness in overweight or obese sedentary young adults

Contact Info

Product

Resources

About