Inverse Relationship Between Fenfluramine-Induced Prolactin Release and Blood Pressure in Humans

Muldoon, Matthew F.; Sved, Alan F.; Flory, Janine D.; Perel, James M.; Matthews, Karen A.; Manuck, Stephen B.

doi:10.1161/01.hyp.32.6.972

Cited by 21 publications

(19 citation statements)

References 22 publications

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“…Results of this study noted a significantly inversely correlation between PRL and the age in whole study population, this finding agree with many studies which found an association between PRL secretion and the age [48,49].…”

Section: Discussionsupporting

confidence: 93%

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Ahmed¹,

Elmahadi²,

Hamza³

et al. 2017

Health Sci J

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Section: Discussionsupporting

confidence: 93%

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Ahmed¹,

Elmahadi²,

Hamza³

et al. 2017

Health Sci J

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“…The association between the reduction of the brain 5-HTergic transmission and hypertension was performed in an article, which investigated if the tonic 5-HTergic activity is related to the variability of rest blood pressure in human beings (Muldoon et al 1998). To evaluate the brain 5-HTergic activity the authors used a neuroendocrine approach, which determined the prolactin secretory capacity through the fenfluramine administration, a 5-HT releaser.…”

Section: Hypertensionmentioning

confidence: 99%

Role of the serotoninergic system in the sodium appetite control

Reis

2007

An. Acad. Bras. Ciênc.

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The present article reviews the role of the serotoninergic system in the regulation of the sodium appetite. Data from the peripheral and icv administration of serotoninergic (5-HTergic) agents showed the participation of 5-HT2/3 receptors in the modulation of sodium appetite. These observations were extended with the studies carried out after brain serotonin depletion, lesions of DRN and during blockade of 5-HT2A/2C receptors in lateral parabrachial nucleus (LPBN). Brain serotonin depletion and lesions of DRN increased the sodium appetite response, in basal conditions, after sodium depletion and hypovolemia or after beta-adrenergic stimulation as well. These observations raised the hypothesis that the suppression of ascending pathways from the DRN, possibly, 5-HTergic fi bers, modifi es the angiotensinergic or sodium sensing mechanisms of the subfornical organ involved in the control of the sodium appetite. 5-HTergic blockade in LPBN induced to similar results, particularly those regarded to the natriorexigenic response evoked by volume depletion or increase of the hypertonic saline ingestion induced by brain angiotensinergic stimulation. In conclusion, many evidences lead to acceptation of an integrated participation resulting of an interaction, between DRN and LPBN, for the sodium appetite control.

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“…Baseline age was modeled by dummy-coded variables for ages 48,54, and 60 years, with an age of 42 years as the reference category.…”

Section: Agementioning

confidence: 99%

Hypertension Incidence Is Predicted by High Levels of Hopelessness in Finnish Men

et al. 2000

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Abstract-Recent studies have reported that hopelessness is an important factor in cardiovascular morbidity and mortality, including ischemic heart disease, acute myocardial infarction, and atherosclerotic progression. This study examined the relationship between hopelessness and incident hypertension in a population-based sample of 616 initially normotensive, middle-aged men from eastern Finland, an area with high rates of cardiovascular disease. Participants completed a medical examination and a series of psychological questionnaires at baseline and at the 4-year follow-up. Hopelessness was measured by 2 items assessing negative expectancy about the future and one's goals. A logistic regression model with adjustments for age, body mass index, baseline resting blood pressure, physical activity, smoking, alcohol consumption, education, parental history of hypertension, and self-reported depressive symptoms revealed that men reporting high levels of hopelessness at baseline were 3 times more likely to become hypertensive (systolic blood pressure Ն165 mm Hg and/or a diastolic blood pressure Ն95 mm Hg or confirmed use of antihypertensive medication) in the intervening 4 years than men who were not hopeless (odds ratio, 3.22; 95% confidence interval, 1.56, 6.67). Men reporting moderate levels of hopelessness were not at a significantly increased risk of hypertension (odds ratio, 1.27; 95% confidence interval, 0.79, 2.07). This is the first study to identify a significant relationship between hopelessness and incident hypertension. Research is needed to explore the neuroendocrine and central nervous system mechanisms underlying this association. Key Words: cardiovascular diseases Ⅲ depression Ⅲ hopelessness Ⅲ men Ⅲ psychology Ⅲ risk factors S everal risk factors for hypertension that have important lifestyle and psychosocial components have been identified, including obesity, 1 excess sodium consumption, 2 excess alcohol consumption, 3 and physical inactivity. 4,5 All are associated with an increased risk of hypertension. Research also suggests that psychosocial stress and concomitant sympathetic nervous system reactivity may play a role in hypertension and increases in blood pressure (BP) over time, 6 -8 as may certain emotions, including anger, anxiety, and depression. 9 -11 Previously, we reported that hopelessness, characterized as a sense of futility and negative expectations about the future and one's personal goals, predicts incident myocardial infarction and cardiovascular mortality 12 and is associated with a faster progression of carotid atherosclerosis 13 in middle-aged men. In both cases, the effects of hopelessness on cardiovascular disease morbidity and mortality were unchanged after controlling for depressive symptoms in general. Data from the National Health Examination Follow-up Survey also demonstrated that hopelessness was related to incident fatal and nonfatal ischemic heart disease in men and women during 12 years of follow-up and that the effect of hopelessness was stronger than the effect of d...

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Inverse Relationship Between Fenfluramine-Induced Prolactin Release and Blood Pressure in Humans

Cited by 21 publications

References 22 publications

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Assessment of Thyroid Functions Test among Hyperprolactinemic Sudanese Infertile Females

Role of the serotoninergic system in the sodium appetite control

Hypertension Incidence Is Predicted by High Levels of Hopelessness in Finnish Men

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