Inverse relationship between cord blood adiponectin concentrations and the number of cigarettes smoked during pregnancy

Pardo, Inês Maria Crespo Gutierres; Geloneze, Bruno; Tambascia, Marcos Antônio; Barros, António André Chivanga

doi:10.1111/j.1463-1326.2004.00379.x

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…Another study suggested a reverse correlation between PI and adiponectin concentration (11,25). Some studies have shown a positive correlation between adiponectin concentration and birth weight (8,12,14,(16)(17)(18)(19)(20), but few have failed to find a significant correlation (9,15). The current study found a positive correlation between adiponectin concentration and gestational age in the GDM group although there was no such correlation in the NGT group.…”

Section: Discussioncontrasting

confidence: 39%

“…In adults, adiponectin concentration is inversely related to adiposity, but its association with adiposity is poorly understood (9,11,13). Some studies indicate a positive correlation between cord plasma adiponectin concentration and adiposity in infants (8,12,14,(16)(17)(18)(19)(20) and some have found no significant correlation (9,15).…”

Section: G Estational Diabetes Mellitus (Gdm) Is Impairedmentioning

confidence: 99%

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Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Aramesh

Dehdashtian

Malekian

et al. 2017

Arch. Endocrinol. Metab.

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Objectives:The objectives were to evaluate the relation between fetal anthropometric parameters and cord blood concentration of adiponectin and high sensitivity C-reactive protein (hs-CRP). Subjects and methods: A total of 104 pregnant women (52 with gestational diabetes mellitus [GDM], 52 with normal glucose tolerance (NGT) participated. Venous cord blood samples were obtained at delivery, centrifuged and the plasma was stored at -20°C. The samples were assessed for adiponectin and hs-CRP using the ELISA method. Statistical analysis was done using SPSS software. Results: The adiponectin concentration was higher in the GDM group than in the NGT group (11.05 ± 4

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Section: Discussioncontrasting

confidence: 39%

Section: G Estational Diabetes Mellitus (Gdm) Is Impairedmentioning

confidence: 99%

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Aramesh

Dehdashtian

Malekian

et al. 2017

Arch. Endocrinol. Metab.

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“…Most prior studies found no difference in cord blood leptin [12, 14, 15, 21] or adiponectin [14] in infants of mothers who smoked versus did not smoke during pregnancy, although a few found lower cord blood leptin [18] and adiponectin [12, 20] in infants of smokers. While prior studies did not evaluate the association between prenatal smoking and C-peptide, thought to be a more stable marker of pancreatic function than insulin due to its longer half-life [38], of two studies that evaluated cord blood insulin, one [19] found lower insulin in smokers, and the other [14] found no difference in smokers versus non-smokers.…”

Section: Discussionmentioning

confidence: 99%

Associations of maternal prenatal smoking with umbilical cord blood hormones: the Project Viva cohort

et al. 2017

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Background Maternal smoking during pregnancy is associated with low fetal growth and adverse cardiometabolic health in offspring. However, hormonal pathways underlying these associations are unclear. Therefore, we examined maternal smoking habits and umbilical cord blood hormone profiles in a large, prospective cohort. Methods We studied 978 mother/infant pairs in Project Viva, a Boston-area cohort recruited 1999–2002. We categorized mothers as early pregnancy smokers, former smokers, or never smokers. Outcomes were cord blood concentrations of IGF-1, IGF-2, IGFBP-3, leptin, adiponectin, insulin, and C-peptide. We used linear regression models adjusted for maternal pre-pregnancy body mass index (BMI), race/ethnicity, parity, education, and infant sex. We conducted analyses in the full cohort and stratified by infant sex. Results Thirteen percent of women were early pregnancy smokers, 20% former smokers, and 68% never smokers. Infants of early pregnancy smokers had lower IGF-1 adjusted for IGFBP-3 [−5.2 ng/mL (95% CI: −8.6, −1.7)], with more pronounced associations in girls [−10.7 ng/mL (95% CI: −18.5, −2.9) vs. −4.0 ng/mL (95% CI: −8.4, 0.4) for boys]. Early pregnancy smoking was not associated with cord blood hormones other than IGF-1. Infants of former smokers had a cord blood hormone profile similar to infants of never smokers. Conclusions As compared to mothers who never smoked, early pregnancy smokers had infants with lower cord blood IGF-1 which could prime adverse metabolic outcomes. This provides further reason to support smoking cessation programs in women of reproductive age.

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“…In a previous study, cord blood adiponectin was lower in pregnancies of mothers who smoked compared to nonsmokers [29] . This observation could be of relevance for our findings, because maternal smoking is negatively associated with risk of preeclampsia [30] .…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia and Adiponectin in Cord Blood

Ogland

Romundstad

Vefring³

et al. 2010

Horm Res Paediatr

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Aims: To compare cord blood concentrations of total adiponectin in the offspring of pregnancies with and without preeclampsia. Methods: Using a Luminex analyzer, cord blood adiponectin was measured in 182 singleton pregnancies with preeclampsia and compared to adiponectin measured in 511 singleton pregnancies without preeclampsia. Results: Adiponectin levels in cord blood increased with increasing gestational age, but overall, crude levels were similar in pregnancies with and without preeclampsia. However, in pregnancies with early delivery (weeks 32–36), and in pregnancies with delivery after spontaneous contractions, adiponectin levels were higher in the preeclampsia group. Conclusion: In preterm pregnancies and in pregnancies with spontaneous contractions, adiponectin levels in cord blood were higher in the preeclampsia group than in pregnancies without preeclampsia, maybe reflecting the need to optimize energy in preeclampsia.

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Inverse relationship between cord blood adiponectin concentrations and the number of cigarettes smoked during pregnancy

Abstract: Our findings also reveal a significant relationship between the reported number of cigarettes smoked during pregnancy and cord blood adiponectin concentrations (p = 0.01), suggesting that this association could have a causal relationship.

Cited by 13 publications

References 8 publications

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Associations of maternal prenatal smoking with umbilical cord blood hormones: the Project Viva cohort

Preeclampsia and Adiponectin in Cord Blood

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