Inverse relationship between cirrhosis and massive tumours in hepatocellular carcinoma

Abstract

Massive HCC represents a tumour subtype that is associated with young, chronic hepatitis B carriers with non-cirrhotic livers. The clinical implications of this finding are that patients with massive HCC are typically excellent resection candidates barring the presence of gross vascular invasion or distant metastases.

Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver

“…Consistent with previous studies almost every second patient with HCC in NCL was diagnosed with a single tumorous nodule but of larger size [11,27]. The proportion of patients with extrahepatic metastases in our cohort exceeded 25% and was strikingly larger than reported in other cohorts [5,28] with up to 15%.…”

Clinicopathological Features and Prognostic Factors of Young Patients With Surgically Treated Liver Cancer

“…16 These varying results for LC may have been because of the controversy surrounding the definition of young patients with LC. Some studies used 50 years as the cut-off age, 15 , 17 and other studies defined young as 40, 18 , 19 30, 20 or even 45 years. 21 – 24 The morbidity of LC is relatively rare and stable until 45 years.…”

Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence

“…In addition, a decreased PLT level was significantly associated with elevated AFP levels [11,61,62] , both of which are associated with HCC recurrence [63,64] . In contrast, serum PLT levels positively correlate with tumor size in HCC [39,65] , and platelets can stimulate the growth and invasion of several HCC cell lines in vitro [66] . High PLT, such as in thrombocytosis, could also result in many adverse side effects, including deep vein thrombosis [67] .…”