Inverse Relationship Between Central Obesity and Osteoporosis in Osteoporotic Drug Naive Elderly Females: The Tianliao Old People (TOP) Study

Chang, Chin Sung; Chang, Yin Fan; Wang, Mei Wen; Chen, Chuan Yu; Chao, Yu Jang; Chang, Hsuan Jui; Kuo, Po-Hsiu; Yang, Yi Ching; Wu, Chih Hsing

doi:10.1016/j.jocd.2012.03.008

Cited by 47 publications

(46 citation statements)

References 37 publications

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“…Smoking,8 obesity,9 chronic renal failure,10 hyperthyroidism,11 rheumatoid arthritis,12 inflammatory bowel diseases13 are well known to be associated with osteoporosis and have been reported on extensively. Obesity as a protective factor has already been reported 14. To the best of our knowledge, this is the first study to show this association.…”

Section: Discussionsupporting

confidence: 64%

Are cataracts associated with osteoporosis?

Nemet¹,

Hanhart²,

Kaiserman³

et al. 2013

OPTH

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BackgroundCalcium is considered an important factor in the development of both osteoporosis and cataract. This study evaluated the association between osteoporosis and cataracts.ObjectiveTo evaluate the prevalence of osteoporosis among patients undergoing cataract surgery, and the association between the two.Patients and methodsThis was a retrospective observational case-control study, conducted in the Central District of Clalit Health Services (a district of the largest health maintenance organization in Israel). All Clalit members in the district older than 50 years who underwent cataract surgery from 2000 to 2007 (n=12,984) and 25,968 age- and sex-matched controls comprised the sample. Electronic medical records of all patients in the study were reviewed. The main outcome measure was the prevalence of osteoporosis and the odds ratio of having osteoporosis among cataract patients compared with controls.ResultsDemographically, 41.8% were men with a mean age of 68.7 ± 8.2 years. A logistic regression model for osteoporosis showed that age, female sex, higher socioeconomic class, smoking, chronic renal failure, hyperthyroidism, rheumatoid arthritis, inflammatory bowel diseases, and cataract are all associated with increased prevalence of osteoporosis. Obesity is a protective factor for osteoporosis. In all age-groups, osteoporosis was more prevalent in cataract patients than in the control group.ConclusionAmong other well-known risk factors, osteoporosis is associated with the presence of cataracts. Common pathophysiological associations with both conditions, such as calcium imbalance, hormonal abnormalities, and shared genetic predisposition, are discussed.

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Section: Discussionsupporting

confidence: 64%

Are cataracts associated with osteoporosis?

Nemet¹,

Hanhart²,

Kaiserman³

et al. 2013

OPTH

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“…Overall, obesity has a protective effect on osteoporosis because of the increase in bone density related to a higher body weight. While some authors have reported that the increase in adipose tissue was not beneficial for bone density [131415161719], Taes et al [13] reported that increased fat mass is associated with smaller bone size, which was in contrast with the established view that a high BMI is a protective factor for osteoporosis, whereas lean mass is a consistent positive determinant of bone size. Zhao et al [14] showed that increasing fat mass may not have a beneficial effect on bone mass and Janicka et al [15] showed similar results in a group of healthy sexually mature adolescents and young adults.…”

Section: Discussionmentioning

confidence: 99%

“…Zhao et al [14] showed that increasing fat mass may not have a beneficial effect on bone mass and Janicka et al [15] showed similar results in a group of healthy sexually mature adolescents and young adults. Additionally, Chang et al [16] suggested that central obesity was negatively associated with osteoporosis in a population of older women. Other authors have also suggested that obesity may not protect against decreases in bone mass [2627].…”

Section: Discussionmentioning

confidence: 99%

“…While some studies have shown that obesity is positively associated with high bone mass [101112] as a result of the obesity-related increased levels of leptin, insulin, and estrogen that stimulate bone growth and inhibit bone remodeling, several studies have reported that obesity was negatively associated with bone mass [1314151617]. These studies, however, have been focused on a specific gender, age, or site of measurement and few studies have compared the obesity paradox in men and pre- and postmenopausal women, even though patterns and occurrence of obesity, fat distribution, and osteoporosis are different between men and women and between pre- and postmenopausal women [1819].…”

Section: Introductionmentioning

confidence: 99%

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Association between Obesity and Bone Mineral Density by Gender and Menopausal Status

Salamat

Janghorbani

2016

Endocrinol Metab

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BackgroundWe investigated whether there were gender differences in the effect of obesity on bone mineral density (BMD) based on menopausal status.MethodsWe assessed 5,892 consecutive patients 20 to 91 years old who were referred for dual-energy X-ray absorptiometry (DXA) scans. All subjects underwent a standard BMD scan of the hip (total hip and femoral neck) and lumbar spine (L1 to L4) using a DXA scan and body size assessment. Body mass index was used to categorize the subjects as normal weight, overweight, and obese.ResultsBMD was higher in obese and overweight versus normal weight men, premenopausal women, and postmenopausal women. Compared to men ≥50 years and postmenopausal women with normal weight, the age-adjusted odds ratio of osteopenia was 0.19 (95% confidence interval [CI], 0.07 to 0.56) and 0.38 (95% CI, 0.29 to 0.51) for obese men ≥50 years and postmenopausal women. Corresponding summaries for osteoporosis were 0.26 (95% CI, 0.11 to 0.64) and 0.15 (95% CI, 0.11 to 0.20), respectively. Compared to men <50 years and premenopausal women with normal weight, the age-adjusted odds ratio of low bone mass was 0.22 (95% CI, 0.11 to 0.45) and 0.16 (95% CI, 0.10 to 0.26) for obese men <50 years and premenopausal women, respectively.ConclusionObesity is associated with BMD of the hip and lumbar spine and overweight and obese individuals have similar degrees of osteoporosis. This result was not significantly different based on gender and menopausal status, which could be an important issue for further investigation.

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“…We used 4 studies, excluding one study in which body composition was not measured. The four individual cohort studies comprising the present study were Healthy Aging Longitudinal Study in Taiwan (HALST) (n = 990), Taichung Community Health Study for the Elderly (TCHS-E) (n = 1042), Tianliao Old People (TOP) study (n = 549), and Comprehensive Geriatric Assessment and Frailty Study of Elderly Outpatients (CGAFSEO) (n = 431) [21-23]. These studies recruited subjects representative of older residents living in the northern (HALST, CGAFSEO), central (TCHS-E), and southern (HALST, TOP) regions of Taiwan.…”

Section: Methodsmentioning

confidence: 99%

Combined association of chronic disease and low skeletal muscle mass with physical performance in older adults in the Sarcopenia and Translational Aging Research in Taiwan (START) study

Lin

et al. 2015

BMC Geriatr

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BackgroundMultiple chronic conditions and low skeletal muscle mass are common features of aging that are detrimental to physical performance. This study evaluates the simultaneous impact of these conditions on physical performance in older adults.MethodsFive studies from 2003 to 2012 were pooled to include 2,398 adults aged ≥65 years with diagnosed chronic diseases measured by self-administered questionnaire. Low muscle mass was defined as an appendicular skeletal muscle mass index less than that of the sex-specific lowest quintile in the population of older adults. Poor physical performances were defined as the lowest quintile of grip strength and gait speed in the population of older adults and the slowest sex-specific 20% of Timed Up and Go (TUG) test at each study site. Chi-squared and logistic regression tests were applied for data analysis.ResultsMean age of the study participants, of whom approximately 50% were men, was 74.3 years. Slow gait speed was nearly three times more likely to occur in the presence of low muscle mass coupled with chronic disease than in the absence of both factors after adjustment for study site, age, sex, education, marital status, body mass index, tobacco and alcohol use, and comorbidities. The independent effect of low muscle mass was generally stronger than that of each disease. Participants with more than two chronic diseases and low muscle mass were significantly more likely to perform poorly than those with no risk factors (odds ratio [OR] = 2.51 in patients with low grip strength, OR = 3.89 in patients with low gait speed, and OR = 3.67 in patients with poor TUG test scores, all P < 0 .05) after adjustment.ConclusionsThe combined association of chronic disease and low skeletal mass with physical performance was stronger than the effect of either factor alone.

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Inverse Relationship Between Central Obesity and Osteoporosis in Osteoporotic Drug Naive Elderly Females: The Tianliao Old People (TOP) Study

Cited by 47 publications

References 37 publications

Are cataracts associated with osteoporosis?

Are cataracts associated with osteoporosis?

Association between Obesity and Bone Mineral Density by Gender and Menopausal Status

Combined association of chronic disease and low skeletal muscle mass with physical performance in older adults in the Sarcopenia and Translational Aging Research in Taiwan (START) study

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