Inverse problem of laser correlation spectroscopy for analysis of polydisperse solutions of nanoparticles

Nepomnyashchaya, Elina; Velichko, Elena; Aksenov, E. T.

doi:10.1088/1742-6596/769/1/012025

Cited by 36 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To identify regularities in the scattered signals, the autocorrelation or cross-correlation (in the case of a simultaneous registration of two scattered signals) functions were calculated. Further analysis was carried out by using the original modification of the Tikhonov's mathematical technique for ill-posed problems [4].…”

Section: Methodsmentioning

confidence: 99%

Modifications of laser correlation spectrometer for investigation of biological fluids

et al. 2017

View full text Add to dashboard Cite

Abstract. We suggest three modifications of a laser correlation spectrometer for analysis of complex multicomponent biological solutions based on: (i) dynamic light scattering with special signal processing for analysis of polydisperse solutions, (ii) use of polarimetric technique for shape analysis, (iii) cross-correlation processing. The schemes of the devices based on polarization and cross-correlation analysis are described.

show abstract

Section: Methodsmentioning

confidence: 99%

Modifications of laser correlation spectrometer for investigation of biological fluids

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Оптический блок спектрометра состоит из оптических элементов, фокусирующих лазерный на кювете с исследуемым образцом биологической жидкости и собирающих рассеянный свет от кюветы с находящейся в ней исследуемой НБЖ на фотоприемное устройство [45]. Оптический блок спектрометра выполняет фиксацию положения лазера, фотоприемного устройства и элементов формирующей оптики.…”

Section: материалы и методыunclassified

Algorithm of rapid diagnosis of chronic autoimmune hepatitis by saliva by the method of monochrome analysis of nanoparticles

Choi¹

2022

jour

View full text Add to dashboard Cite

Сhronic autoimmune hepatitis is an urgent problem of modern medicine due to the widespread prevalence among all autoimmune diseases (more than 25%) and the diffi culty of its diagnosis due to the lack of reliable serological tests for its detection. The purpose of this work was to study the possibility of the method of monochrome analysis of nanoparticles in noninvasive detection of AIG and to develop an algorithm for rapid diagnosis of chronic autoimmune hepatitis by saliva.The goal was solved by performing a number of tasks: the development of a diagnostic algorithm for monochrome analysis of nanoparticles to determine the severity and pathophysiological orientation of homeostatic shifts in patients with a verifi ed diagnosis of chronic autoimmune hepatitis using samples of oropharyngeal fl ushes (saliva), as well as the calculation of diagnostic specifi city and sensitivity of the test. Materials and methods:The studies were conducted at the Center for European and Oriental Medicine from 2019 to 2022, and 14 patients with a verifi ed diagnosis of autoimmune hepatitis were examined. It was found that the most typical saliva spectra of patients with autoimmune liver damage were characterized by three-modality and predominance of light scattering on particles of super-large diameter (over 1000 nm) and a signifi cant increase in the contribution to light scattering of nanoparticles of small and medium hydrodynamic size, which was statistically signifi cant (p<0.001) when conducting a comparative analysis with the saliva spectra of practically healthy individuals and patients with general somatic liver diseases of non-autoimmune genesis. The indicators of diagnostic sensitivity for autoimmune hepatitis were 95%, diagnostic specifi city -93%.Conclusions: the results of the conducted scientifi c research were the developed algorithm for the use of laser spectroscopy of saliva for noninvasive rapid diagnosis of chronic autoimmune hepatitis, when with a timely diagnosis, therapeutic measures will be maximally eff ective and aimed at preventing complications and systemic manifestations of the disease, and the calculation of diagnostic sensitivity and specifi city of the method of monochrome analysis of nanoparticles.

show abstract

“…By measuring the scattered light intensity fluctuations, in case of the assumption of spherical form of scattering nanoparticles,it is also possible to estimate their sizes and forms by using the Stokes-Einstein's equation[12] …”

mentioning

confidence: 99%

Method of Laser Cross-correlation Optical Spectroscopy for Investigation of Dispersion Medium

Zabalueva¹,

Nepomnyashchaya²,

Velichko³

et al. 2018

KEn

View full text Add to dashboard Cite

show abstract

Inverse problem of laser correlation spectroscopy for analysis of polydisperse solutions of nanoparticles

Cited by 36 publications

References 3 publications

Modifications of laser correlation spectrometer for investigation of biological fluids

Modifications of laser correlation spectrometer for investigation of biological fluids

Algorithm of rapid diagnosis of chronic autoimmune hepatitis by saliva by the method of monochrome analysis of nanoparticles

Method of Laser Cross-correlation Optical Spectroscopy for Investigation of Dispersion Medium

Contact Info

Product

Resources

About