Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical Cancer: 4-Year Outcomes

Tinkle, Christopher L.; Weinberg, Vivian; Chen, Lee-may; Littell, Ramey D.; Cunha, J. Adam M.; Sethi, Rajni; Chan, John K.; Hsu, I‐Chow

doi:10.1016/j.ijrobp.2015.04.018

Cited by 36 publications

(16 citation statements)

References 46 publications

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“…The excellent outcome of IGABT has been demonstrated in several mono-institutional reports as well as in the RetroEMBRACE study [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] . The 3-year local and pelvic control rates reached 98–100% and 96%, respectively, for FIGO stage IB1 and IB2 disease, and 93–96% and 89–91%, respectively, for stage IIB disease [12] , [22] .…”

Section: Current Evidence From the Embrace Studies And Image Guided Amentioning

confidence: 79%

“…The 3-year local and pelvic control rates reached 98–100% and 96%, respectively, for FIGO stage IB1 and IB2 disease, and 93–96% and 89–91%, respectively, for stage IIB disease [12] , [22] . For stage III/IVA disease, the local and pelvic control rates between centres were more variable ranging from 73–86% [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] . In the RetroEMBRACE study, the improved local and pelvic control was associated with an overall survival benefit of around 10% compared to historical cohorts [22] ; a similar benefit was also observed in several mono-institutional reports [12] , [13] , [17] .…”

Section: Current Evidence From the Embrace Studies And Image Guided Amentioning

confidence: 99%

See 1 more Smart Citation

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

Pötter

Tanderup

Kirisits

et al. 2018

Clinical and Translational Radiation Oncology

491

441

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Section: Current Evidence From the Embrace Studies And Image Guided Amentioning

confidence: 79%

Section: Current Evidence From the Embrace Studies And Image Guided Amentioning

confidence: 99%

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

Pötter

Tanderup

Kirisits

et al. 2018

Clinical and Translational Radiation Oncology

491

441

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show abstract

“…For cervix BT, inverse planning algorithms, especially the IPSA algorithm, have been implemented by several institutions and positive results have been published 3–10,12 . Recent clinical results further verified the use of IPSA in the clinics 34,35 . Kim et al and Tinkle et al successively concluded that IPSA‐planned HDR BT is well tolerated with minimal toxicities and achieves excellent local control.…”

Section: Discussionmentioning

confidence: 99%

Comparison of two inverse planning algorithms for cervical cancer brachytherapy

Zuo

et al. 2021

J Applied Clin Med Phys

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Purpose: To compare two inverse planning algorithms, the hybrid inverse planning optimization (HIPO) algorithm and the inverse planning simulated annealing (IPSA) algorithm, for cervical cancer brachytherapy and provide suggestions for their usage. Material and methods: This study consisted of 24 cervical cancer patients treated with CT image-based high-dose-rate brachytherapy using various combinations of tandem/ovoid applicator and interstitial needles. For fixed catheter configurations, plans were retrospectively optimized with two methods: IPSA and HIPO. The dosimetric parameters with respect to target coverage, localization of high dose volume (LHDV), conformal index (COIN), and sparing of organs at risk (OARs) were evaluated. A plan assessment method which combines a graphical analysis and a scoring index was used to compare the quality of two plans for each case. The characteristics of dwell time distributions of the two plans were also analyzed in detail. Results: Both IPSA and HIPO can produce clinically acceptable treatment plans. The rectum D 2cc was slightly lower for HIPO as compared to IPSA (P = 0.002). All other dosimetric parameters for targets and OARs were not significantly different between the two algorithms. The generated radar plots and scores intuitively presented the plan properties and enabled to reflect the clinical priorities for the treatment plans. Significant different characteristics were observed between the dwell time distributions generated by IPSA and HIPO. Conclusions: Both algorithms could generate high-quality treatment plans, but their performances were slightly different in terms of each specific patient. The clinical decision on the optimal plan for each patient can be made quickly and consistently with the help of the plan assessment method. Besides, the characteristics of dwell time distribution were suggested to be taken into account during plan selection. Compared to IPSA, the dwell time distributions generated by HIPO may be closer to clinical preference.

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“…For cervix BT, inverse planning algorithms, especially the IPSA algorithm, have been implemented by several institutions and positive results have been published [3][4][5][6][7][8][9][10]. Recent clinical results further veri ed the use of IPSA in the clinics [33,34]. Kim et al and Tinkle et al successively concluded that IPSAplanned HDR BT is well tolerated with minimal toxicities and achieves excellent local control.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Two Inverse Planning Algorithms for Cervical Cancer Brachytherapy

Zuo

et al. 2020

Preprint

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Purpose: To compare two methods, the hybrid inverse planning optimization (HIPO) algorithm and the inverse planning simulated annealing (IPSA) algorithm, for cervical cancer brachytherapy and provide suggestions for their usage.Material and methods: This study consisted of 24 cervical cancer patients treated with CT image-based high-dose-rate brachytherapy using various combinations of tandem/ovoid applicator and interstitial needles. For fixed catheter configurations, plans were retrospectively optimized with two methods: IPSA and HIPO. The dosimetric parameters with respect to target coverage, localization of high dose volume (LHDV), conformal index (COIN), and sparing of organs at risk (OARs) were evaluated. A plan assessment method which combines a graphical analysis and a scoring index was used to compare the quality of two plans for each case. The characteristics of dwell time distributions of the two plans were also analyzed.Results: Both IPSA and HIPO can produce clinically acceptable treatment plans. The rectum D2cc was slightly lower for HIPO as compared to IPSA (p=0.002). All other dosimetric parameters for targets and OARs were not significantly different between the two algorithms. The generated radar plots and scores intuitively presented the plan properties and enabled to reflect the clinical priorities for the treatment plans. Different characteristics were observed between the dwell time distributions generated by IPSA and HIPO. Conclusions: Despite significant difference in dwell time distributions, both the two algorithms could generate high-quality treatment plans. With the help of the plan assessment method, the clinical decision on the optimal plan can be made quickly and consistently for each patient.

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Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical Cancer: 4-Year Outcomes

Cited by 36 publications

References 46 publications

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

Comparison of two inverse planning algorithms for cervical cancer brachytherapy

Comparison of Two Inverse Planning Algorithms for Cervical Cancer Brachytherapy

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