Abstract:Saccharomyces cerevisiaetelomerase RNA, TLC1, is an 1157 nt non-coding RNA that functions as both a template for DNA synthesis and a flexible scaffold for telomerase RNP holoenzyme protein subunits. The tractable budding yeast system has provided landmark discoveries about telomere biologyin vivo, but yeast telomerase research has been hampered by the fact that the large TLC1 RNA subunit does not support robust telomerase activityin vitro. In contrast, 155–500 nt miniaturized TLC1 alleles comprising the cataly… Show more
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