Inverse design of long-range intensity correlation in scattering media

Koirala, Milan; Sarma, Raktim; Cao, Hui; Yamilov, Alexey

doi:10.1103/physrevb.100.064203

Cited by 4 publications

(2 citation statements)

References 61 publications

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“…Due to its longer wavelength, NIR-II light has been reported to have sufficient penetration depth in highly scattering medium. 30,83,84 Such wavelength has also been demonstrated to have the capability of penetrating the human skull, 27,28 potentially enabling non-surgical brain stimulation through light excitation.…”

Section: Articlementioning

confidence: 99%

Neural Stimulation In Vitro and In Vivo by Photoacoustic Nanotransducers

Jiang

Huang

Luo

et al. 2021

Matter

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Neuromodulation is crucial for the understanding of brain circuits and treatment of neurological diseases. This work demonstrates a new photoacoustic nanoparticlebased neural stimulation technique. Synthesized nanoparticles transduce nearinfrared light to ultrasound locally at the neuronal membrane and evoke neural activation in vitro and in vivo. Through targeting the mechanosensitive ion channel TRPV4, the modified nanotransducers achieve neural activation with enhanced specificity. Together, photoacoustic nanotransducers offer opportunities for nongenetic neuromodulation with deep tissue penetration.

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Section: Articlementioning

confidence: 99%

Neural Stimulation In Vitro and In Vivo by Photoacoustic Nanotransducers

Jiang

Huang

Luo

et al. 2021

Matter

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“…Notably under the ns laser with the thermal confinement and stress confinement condition met, many nanoparticles, including Au nanoparticles, can also be photoacoustic 41 PANs uniquely absorb NIR-II light. Due to its longer wavelength, NIR-II light has been reported to have sufficient penetration depth in highly scattering medium 23, 42,43 . Such wavelength has also been demonstrated to have the capability of penetrating human skull 20,21 , potentially enabling nonsurgical brain stimulation through light excitation.…”

Section: Successful In Vivo Activation Through Pans Directly Injectedmentioning

confidence: 99%

Neural Stimulation in vitro and in vivo by Photoacoustic Nanotransducers

Huang

Jiang²,

Luo

et al. 2020

Preprint

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Neuromodulation is an invaluable approach for study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation. Our PANs strongly absorb light in the near-infrared second window and generate localized acoustic waves. PANs can also be surfacemodified to selectively bind onto neurons. PAN-mediated activation of primary neurons in vitro is achieved with ten 3-nanosecond laser pulses at 1030 nm over a 3 millisecond duration. In vivo neural modulation of mouse brain activities and motor activities is demonstrated by PANs directly injected into brain cortex. With millisecond-scale temporal resolution, sub-millimeter spatial resolution and negligible heat deposition, PAN stimulation is a new non-genetic method for precise control of neuronal activities, opening potentials in non-invasive brain modulation.. then utilized the magneto-thermal effect of the paramagnetic nanoparticles to activate these channels 18 . In these studies, significant local temperature rise, exceeding the thermal threshold of the ion channels, e.g. 43 ˚C in the case of TRPV 1, was observed, thus raising concerns over safety of thermally activated brain stimulation. The Khizroev group used the magneto-electric nanoparticles under an applied magnetic field to perturb the voltage-sensitive ion channels for neuron modulation 19 . Notably, these magnetic stimuli-based techniques deliver a spatial precision relying on the confinement of the magnetic field, which is on the millimeter to centimeter scale.New technologies and concepts are still sought to achieve non-invasive, genetic free and precise neural stimulation.Here, we report the development and application of photoacoustic nanotransducers (PANs) to enable non-genetic neural stimulation in cultured primary neurons and in live brain (Figure 1a).Our PANs, based on synthesized semiconducting polymer nanoparticles, efficiently generate localized ultrasound by an optoacoustic process upon absorption of nanosecond pulsed light in the NIR-II window (1000 nm to 1700 nm) (Figure 1b). The NIR-II light has the capability of centimeter-deep tissue penetration 20,21 , which is beyond the reach of visible light currently used in optogenetics. We further modified the PAN surface for non-specific binding to neuronal membrane and specific targeting of mechanosensitive ion channels, respectively. We showed that upon excitation at 1030 nm PANs on the neuronal membrane successfully activated rat cortical neurons, confirmed by real time fluorescence imaging of GCaMP. We then demonstrated in vivo motor cortex activation and invoked subsequent motor responses through PANs directly injected into a mouse living brain. Importantly, the heat generated by the ns laser pulses is confined inside the PAN, resulting in a transient temperature rise during the photoacoustic process, evident by COMSOL simulations. Collectively, our finding shows photoacoustic nanotransducers as a new Collectively, we have ...

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Inverse design of optical correlation induced effects

2023

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A comprehensive theoretical framework for the inverse design of correlation induced effects with optical beams is introduced. Correlation induced effects are able to modify the intensity distribution of an optical beam drastically via effects such as correlation induced splitting, focusing, and shifting. The inverse design steps are given analytically, which allows the analysis of several related experiments. Finally, an algorithm for more complex numerical inverse design is overviewed and demonstrated.

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Inverse design of long-range intensity correlation in scattering media

Cited by 4 publications

References 61 publications

Neural Stimulation In Vitro and In Vivo by Photoacoustic Nanotransducers

Neural Stimulation In Vitro and In Vivo by Photoacoustic Nanotransducers

Neural Stimulation in vitro and in vivo by Photoacoustic Nanotransducers

Inverse design of optical correlation induced effects

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