Inverse Correlation between Caveolin-1 Expression and Clinical Severity in Psoriasis Vulgaris

Ma, WY; Liu, Zhuang; Cai, DX; Zhong, Hua; Zhao, Chenyang; Sun, Qing

doi:10.1177/030006051204000513

Cited by 12 publications

(16 citation statements)

References 23 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Loss of caveolin-1 in epidermal keratinocytes has been shown to contribute to the development of psoriasis. 36, 37, 38, 39 Therefore, we evaluated whether rhododendrin also regulates caveolin-1 expression. Surprisingly, caveolin-1 expression was found to be preserved with downregulation of TLR-7 upon treatment with rhododendrin compared with keratinocytes treated with IMQ alone, suggesting that rhododendrin exerts a critical therapeutic action in the maintenance of skin homeostasis during disease pathogenesis (Figures 5a and b).…”

Section: Resultsmentioning

confidence: 99%

“…It has been shown that the expression level of caveolin-1 is strikingly decreased and its spatial pattern of expression is altered in psoriatic skin. 36, 37, 38, 39 Considerable work has been done to correlate caveolin-1 expression and the activity of receptor kinases with their respective downstream effects. 44 Activation of receptor tyrosine kinases and of the downstream p42/p44 MAP kinase pathway has been implicated in the keratinocyte hyperproliferation that is commonly associated with the pathogenesis of psoriasis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice

et al. 2017

View full text Add to dashboard Cite

Many active compounds present in Rhododendron brachycarpum have been used in traditional Oriental medicine for the treatment of various skin diseases. However, the precise mechanism of action of the compounds isolated from R. brachycarpum and their relevance as therapeutics for the treatment of psoriasis remain elusive. In this study, we report that rhododendrin isolated from R. brachycarpum strongly inhibits imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice. We showed that topical treatment with rhododendrin reduces IMQ-induced skin hyperplasia, inflammatory mononuclear cell infiltration and the expression of pro-inflammatory mediators in mouse skin. In addition, we found that rhododendrin inhibits the activation of the TLR-7/NF-κB and mitogen-activated protein kinase pathways in both IMQ-induced psoriasis-like skin inflammation in mice and in normal human epidermal keratinocytes treated with IMQ. These results suggest that rhododendrin has an anti-inflammatory effect and can be used as a therapeutic to fight against psoriasis and other inflammatory skin diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice

et al. 2017

View full text Add to dashboard Cite

show abstract

“…9 The level of Cav-1 expression was found to be related to the clinical severity of psoriasis. 7,9 Moreover, enhanced expression of Cav-1 through administration of Cav-1 scaffolding domain peptide which is a mimetic of the Cav-1 function provided substantial improvement of psoriasiform dermatitis in mice by regulating the cytokine network, including TNF-α. 8 Cav-1 is therefore not only a marker, but also a target for the treatment of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Caveolin-1 as a pathophysiological factor and target in psoriasis

Kruglikov¹,

Scherer

2019

npj Aging Mech Dis

View full text Add to dashboard Cite

Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psoriasis. At the same time, the interfacial layers of the white adipose tissue (WAT) adjacent to psoriatic lesions demonstrate much higher stiffness, which also points to a modification of Cav-1 expression in this tissue. These processes are connected with each other and regulated via exosomal exchange. Here we discuss the role of Cav-1 expression in inflammatory and hyperproliferative processes and analyze the ways to provide spatially different modulation of Cav-1 expression in the skin and WAT. Such modulation can be induced by different pharmacological and physical factors. These include application of mechanical stress and supra-physiological temperatures. Cav-1 should therefore be considered as an important target in treatment of psoriasis.

show abstract

“…[18] In 2002, Campbell and Laidler demonstrated downregulation and altered spatial expression patterns of Caveolin-1 in psoriasis vulgaris. [1920] These studies investigated Caveolin-1 expression in psoriasis vulgaris by using immunohistochemical approaches, but did not find Caveolin-1 expression in other forms of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Caveolin-1 expression in different types of psoriatic lesions: Analysis of 66 cases

Zhang

Zhou

et al. 2014

Indian J Dermatol

View full text Add to dashboard Cite

Background:Caveolin-1 is a key structural and functional protein. Caveolin-1 is known to modulate multiple signal-transducing pathways involved in cell differentiation and proliferation. Psoriasis is viewed as a multifactorial pathology characterized by keratinocyte hyperproliferation and abnormal cell maturation.Objectives:To examine the expression of caveolin-1 in skin biopsies from normal subjects, patients, and subjects with the three respective isoforms of psoriasis (psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis). The expression level of caveolin-1 was compared among psoriasis vulgaris, localized pustular psoriasis, erythrodermic psoriasis, and normal subjects.Materials and Methods:Using immunohistochemical methods, caveolin-1 protein expression was assayed in four groups. An analysis was conducted on skin samples obtained from 22 normal subjects and 28 patients with psoriasis vulgaris, 22 patients with localized pustular psoriasis, and 16 patients with erythrodermic psoriasis. The statistical analysis of the scoring criteria reflecting the level of Caveolin-1 immunostaining between different groups was determined using the Mann–Whitney U-test.Results:In the normal skin, intense and consistent caveolin-1 staining was present in 22 cases. The Caveolin-1 protein was significantly reduced and showed very weak or absent staining within the tissues of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis (respective P < 0.001). Caveolin-1 protein expression in psoriasis vulgaris was higher than that in localized pustular psoriasis and erythrodermic psoriasis (respective P < 0.05). Caveolin-1 protein expression was no different in localized pustular psoriasis and erythrodermic psoriasis (P > 0.05).Conclusion:The finding of this study was consistent with a downregulation of Caveolin-1, which might serve as an etiological factor in the development of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis. Further mechanistic investigations are required to prove that Caveolin-1 protein has the potential and may be a novel target for therapy of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis.

show abstract

Inverse Correlation between Caveolin-1 Expression and Clinical Severity in Psoriasis Vulgaris

Cited by 12 publications

References 23 publications

Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice

Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice

Caveolin-1 as a pathophysiological factor and target in psoriasis

Caveolin-1 expression in different types of psoriatic lesions: Analysis of 66 cases

Contact Info

Product

Resources

About