Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-β

Abstract

There was a strong inverse correlation between allergy markers and H. pylori infection in pediatric patients associated with elevated levels of TGF-β locally and systemically. H. pylori-associated chronic gastritis might downregulate clinical allergy expression.

Extragastric Manifestations of Helicobacter pylori Infection

“…Arnold et al [15] performed a study on an animal model of allergic airway disease and H. pylori infection; interestingly, H. pylori protected animals from airway hyper-responsiveness and prevented allergen-induced pulmonary and bronchoalveolar infiltration by eosinophils, Th2 cells, and Th17 cells. Serrano et al [16] also confirmed the presence of an inverse relationship between allergy markers and H. pylori infection in children, which in turn correlated with elevated levels of TGF-ß both locally and systemically. An article published in the New England Journal of Medicine [17] showed that children who lived on farms and who were exposed to an increased range of microbes had a reduced incidence of asthma.…”

Is Helicobacter Pylori infection inversely associated with atopy? A systematic review and meta‐analysis

“…Serrano et al. found a significantly lower prevalence of skin sensitization to any specific allergen amongst H. pylori positive children, but not in adults.…”

“…Of the 22 studies eligible for review, seventeen used a cross‐sectional design , three used a case–control design , and two used a cohort design . The majority of the studies were undertaken in adults from 18 to 74 years, with only six performed in children (aged 3 – 17 years) and one in both children and adults . The total number of individuals in all 22 studies eligible for review was 21 348 (Table ).…”

Review: Prevalence and dynamics of Helicobacter pylori infection during childhood

“…The cross‐sectional studies on H. pylori infection in symptomatic children as detected by histology are summarized in Figure [references: ] . H. pylori prevalence estimates vary greatly (3%‐76%) with an overall random‐effects regression model estimate of 39% (95% CI: 35%‐43%).…”