Inverse biological coupling between the bone-specific transcription factor Runx2 and the tumor suppressor P53 levels in osteosarcoma

Taipaleenmäki, Hanna; Deen, Margaretha van der; Zhang, Y.; Lian, Jane B.; Stein, Janet L.; Wijnen, André J. van

doi:10.1016/j.bone.2012.02.168

Cited by 2 publications

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“…RUNX2, a master regulator of osteoblast differentiation and suppressor of proliferation, is aberrantly expressed in OS, and may support OS cell growth. Taipaleenmaki et al , 14 studying the possible contribution of microRNAs (miRNAs) to modulations in RUNX2 levels, discovered that elevated RUNX2 protein expression is directly linked to diminished expression of several RUNX2 targeting miRNAs. In particular, the p53-dependent miR-34c was shown to be an integral part of a novel regulatory network that controls proliferation of bone cells and is compromised in OS.…”

Section: Maria Luisa Bianchimentioning

confidence: 99%

News on bone metabolism and bone density in health and diseases during growing age: ECTS 2012

Bianchi¹

2012

IBMS BoneKEy

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At the ECTS Congress recently held in Stockholm, many communications in both basic and clinical sessions were focused on bone metabolism in health and disease during the growing age. This is a short report on some novel insights in the pathogenesis or treatment of rare diseases and on some other ' hot ' topics still under discussion and requiring special attention.The reappearance of nutritional rickets in developed, and even sunny, countries has been known for several years, but is still often neglected. This was underlined by Karras et al. , 1 who observed a high incidence of vitamin-D deficiency in mothers (82.3 % ) and neonates (62.5 % ) in a region of Northern Greece. Thomsen et al. , 2 in a study on 107 women and their children, found that maternal 25-OH D-status at delivery was the main determinant of infant 25-OH D-status even 9 months after birth. Maternal 25-OH D-levels >50 nmol l − 1 are required to avoid infant deficiency. Low 25-OH D-levels at birth were associated with impaired growth during the first 9 months of life. This confirmed the epidemiological data and prospective studies showing that maternal vitamin-D levels are important for healthy bone density accrual in children, not only during the first months of life but throughout infancy. Vitamin-D supplementation during pregnancy remains controversial, but a randomized trial by Hollis 3 showed that 4000 IU per day of vitamin D in pregnant women are safe and effective in achieving sufficiency in mothers and neonates, regardless of race. Hollis 3 also reported that in a group of 350 women receiving different daily doses of vitamin D (400, 2000 or 4000 IU) during the last 6 months of pregnancy, those receiving the higher doses had less pregnancy-related morbidities, such as preeclampsia, eclampsia or gestational hypertension. More studies are of course needed to translate these findings in general practice. Vitamin-D assessment, particularly in children, might become easier and cheaper if the preliminary results of a newly adapted enzyme immunoassay that measures vitamin D on spot urine samples 4 will be confirmed in a larger population.The importance of physical activity (PA) for bone has been the subject of several communications. Regular moderate to vigorous PA is associated with greater bone strength and density during childhood and adolescence, but its relevance for bone health in the long term is still controversial. A Swedish study 5 showed that PA in younger years was associated with a lower risk of sustaining a fracture. Comparing 709 former male athletes (median age 70 years; regular sport activity ceased for a median of 35 years) with 1368 controls, the authors observed a lower risk of sustaining any fracture, any fragility fracture and distal radius fractures in the former athletes, even if, after age 50 years, the difference was not statistically significant for hip fractures. To demonstrate that PA in early youth can reduce the incidence of fragility fractures in the elderly age would be extremely important to design strategies aimed...

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Section: Maria Luisa Bianchimentioning

confidence: 99%