Inverse association of total polyphenols and flavonoids intake and the intake from fruits with the risk of gestational diabetes mellitus: A prospective cohort study

Gao, Qin; Zhong, Chunrong; Zhou, Xian; Chen, Renjuan; Xiong, Ting; Miao, Hong; Li, Qian; Kong, Man; Xiong, Guoping; Han, Weizhen; Sun, Guoqiang; Yang, Xuefeng; Yang, Nianhong; Hao, Liping

doi:10.1016/j.clnu.2020.05.053

Cited by 25 publications

(24 citation statements)

References 39 publications

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“…In studies assessing the association between polyphenol consumption and the risk of GDM, women were recruited from hospitals [ 24 , 26 , 27 , 30 , 31 ] or national cohort studies [ 25 , 28 , 29 ]. In articles assessing the risk of PE, three studies were hospital or care practices based [ 20 , 21 , 22 ] and one was a national cohort study [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Association of Polyphenols Consumption with Risk for Gestational Diabetes Mellitus and Preeclampsia: A Systematic Review and Meta-Analysis

et al. 2022

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Gestational Diabetes Mellitus (GDM) and preeclampsia (PE) affects 6–25% of pregnancies and are characterized by an imbalance in natural prooxidant/antioxidant mechanisms. Due to their antioxidant and anti-inflammatory properties, polyphenols consumption during the pregnancy might exert positive effects by preventing GDM and PE development. However, this association remains inconclusive. This systematic review and metanalysis is aimed to analyze the association between polyphenol-rich food consumption during pregnancy and the risk of GDM and PE. A systematic search in MEDLINE, EMBASE, and Web of Science (Clarivate Analytics, London, United Kingdom) for articles dated between 1 January 1980 and July 2022 was undertaken to identify randomized controlled trials and observational studies evaluating polyphenol-rich food consumption and the risk of GDM and PE. The Newcastle-Ottawa Scale was used to evaluate the quality of these included studies. Twelve studies were included, of which eight articles evaluated GDM and four studied PE. A total of 3785 women presented with GDM (2.33%). No association between polyphenol consumption and GDM was found (ES = 0.85, 95% CI 0.71–1.01). When total polyphenol intake was considered, a lower likelihood to develop GDM was noted (ES = 0.78, 95% CI 0.69–0.89). Furthermore, polyphenol consumption was not associated with PE development (ES = 0.90, 95% CI 0.57–1.41). In conclusion, for both outcomes, pooled analyses showed no association with polyphenol-rich food consumption during pregnancy. Therefore, association of polyphenol intake with a decreased risk of GDM and PE remains inconclusive.

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Section: Resultsmentioning

confidence: 99%

Association of Polyphenols Consumption with Risk for Gestational Diabetes Mellitus and Preeclampsia: A Systematic Review and Meta-Analysis

et al. 2022

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“…High flavonoids intake was correlated with lower risk of 5-year all-cause mortality (Ivey et al, 2015), and with lower mortality associated with cardiovascular disease and with cancer (Bondonno et al, 2019). Data from meta-analyses suggested that flavonoids have a role in preventing obesity, type 2 diabetes mellitus and even gestational diabetes mellitus (Chen et al, 2015;Dinda et al, 2020;Gao et al, 2020;Liu et al, 2014;Xu et al, 2018). Flavonoids have known anti-diabetic A diet rich in luteolin led to enhanced GLP-1 plasma levels in mice (Kwon & Choi, 2018), supporting our data; however, the authors did not address the question if increased GLP-1 in plasma is due to reduced degradation or increased secretion of GLP-1.…”

Section: Discussionmentioning

confidence: 99%

“…High flavonoids intake was correlated with lower risk of 5‐year all‐cause mortality (Ivey et al, 2015), and with lower mortality associated with cardiovascular disease and with cancer (Bondonno et al, 2019). Data from meta‐analyses suggested that flavonoids have a role in preventing obesity, type 2 diabetes mellitus and even gestational diabetes mellitus (Chen et al, 2015; Dinda et al, 2020; Gao et al, 2020; Liu et al, 2014; Xu et al, 2018). Flavonoids have known anti‐diabetic activities, influencing insulin signalling, insulin secretion (Bardy et al, 2013), glucose uptake and adipose deposition (extensively reviewed here; Al‐Ishaq et al, 2019; Kawser Hossain et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues

Anghel

Badea

Chirițoiu

et al. 2022

British J Pharmacology

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Background and Purpose Glucagon‐like peptide 1 (GLP‐1) is a hormone derived from preproglucagon. It is secreted by enteroendocrine cells in response to feeding and, in turn, acts as a critical regulator of insulin release. Modulating GLP‐1 secretion holds promise as a strategy for controlling blood glucose levels. Experimental Approach To dissect GLP‐1 regulation and discover specific secretagogues, we engineered a reporter cell line introducing a luciferase within the proglucagon sequence in GLUTag cells. The assay was validated using western blotting and ELISA. A focused natural compounds library was screened. We measured luminescence, glucose uptake and ATP to investigate the mechanism by which newly found secretagogues potentiate GLP‐1 secretion. Key Results The newly created reporter cell line is ideal for the rapid, sensitive and quantitative assessment of GLP‐1 secretion. The small molecule screen identified non‐toxic GLP‐1 modulators. Quercetin is the most potent newly found GLP‐1 secretagogue, while other flavonoids also potentiate GLP‐1 secretion. Quercetin requires glucose and extracellular calcium to act as GLP‐1 secretagogue. Our results support a mechanism whereby flavonoids cause GLUTag cells to utilize glucose more efficiently, leading to elevated ATP levels, followed by KATP channel blockade and GLP‐1 exocytosis. Conclusion and Implications Our methodology enabled finding of new GLP‐1 secretagogues. Quercetin is a potent, naturally occurring GLP‐1 secretagogue. Mechanistic studies of newly found secretagogues are possible in newly created reporter cell line. Further validation in more physiological systems, such as primary L‐cells or whole organisms, is needed. GLP‐1 secretagogues might serve as leads for developing alternative glucose‐lowering therapies.

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“…In addition, a meta-analysis including thirty-two randomised controlled trials also indicated that anthocyanins were beneficial for glycaemic control by reducing fasting blood glucose, 2-h postprandial glucose and HbA1c (15) . Second, anthocyanin-rich fruit also contains low sugar and moderate amounts of other nutrients that may help decrease GDM risk, such as fruit fibre (41) , vitamin C (42) , β-carotenoids (14) and other phytochemicals (43) .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have suggested that specific fruit subtypes and not all fruits may affect the risk of T2DM, due to their different carbohydrate quality and quantity and specific flavonoids content (12,13) . Anthocyanin, a typical flavonoid characterised by its antioxidative property, may be beneficial for minimising diabetes risk (14,15) . Furthermore, anthocyanin is mainly consumed by the Chinese population in the form of fruits, and some studies have suggested that anthocyanin-rich fruits can lower the risk of T2DM (16,17) , considering GDM may share the similar pathogenesis with T2DM, we hypothesised that anthocyanin-rich fruit is associated with the risk of GDM; however, the association between anthocyaninrich fruits and GDM has not been well researched.…”

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confidence: 99%

Specific fruit but not total fruit intake during early pregnancy is inversely associated with gestational diabetes mellitus risk: a prospective cohort study

Sun

Dong

Zhang

et al. 2021

Public Health Nutr.

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Objectives: Fruit intake may influence gestational diabetes mellitus (GDM) risk. However, prospective evidence remains controversial and limited. The current study aimed to investigate whether total fruit and specific fruit intake influence GDM risk. Design: A prospective cohort study was conducted. Dietary information was collected by a 3-d 24-h dietary recall. All participants underwent a standard 75-g oral glucose tolerance test at 24–28 gestational weeks. Log-binomial models were used to estimate the association between fruit intake and GDM risk, and the results are presented as relative risks (RR) and 95 % CI. Setting: Southwest China. Participants: Totally, 1453 healthy pregnant women in 2017. Results: Total fruit intake was not associated with lower GDM risk (RR of 1·03 (95 % CI 0·83, 1·27) (Ptrend = 0·789)). The RR of GDM risk was 0·73 for the highest anthocyanin-rich fruit intake quartile compared with the lowest quartile (95 % CI 0·56, 0·93; Ptrend = 0·015). A higher grape intake had a linear inverse association with GDM risk (Q4 v. Q1: RR = 0·65; 95 % CI 0·43, 0·98; Ptrend = 0·044), and after further adjustment for anthocyanin intake, the inverse association tended to be non-linear (Q4 v. Q1: RR = 0·65; 95 % CI 0·44, 0·98; Ptrend = 0·079). However, we did not find an association between glycaemic index-grouped fruit, glycaemic load-grouped fruit or other fruit subtype intake and GDM risk. Conclusions: In conclusion, specific fruit intake (particularly anthocyanin-rich fruit and grapes) but not total fruit intake was inversely associated with GDM risk.

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Inverse association of total polyphenols and flavonoids intake and the intake from fruits with the risk of gestational diabetes mellitus: A prospective cohort study

Cited by 25 publications

References 39 publications

Association of Polyphenols Consumption with Risk for Gestational Diabetes Mellitus and Preeclampsia: A Systematic Review and Meta-Analysis

Association of Polyphenols Consumption with Risk for Gestational Diabetes Mellitus and Preeclampsia: A Systematic Review and Meta-Analysis

Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues

Specific fruit but not total fruit intake during early pregnancy is inversely associated with gestational diabetes mellitus risk: a prospective cohort study

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