Inverse Association Between Total Bilirubin and Metabolic Syndrome in Rural Korean Women

Kwon, Kyung Min; Kam, Jin Hwa; Kim, Min Young; Kim, Moon Young; Chung, Choon Hee; Kim, Jong Koo; Linton, John A.; Eom, Aeyong; Koh, Sang Baek; Kang, Hee-Taik

doi:10.1089/jwh.2010.2453

Cited by 32 publications

(34 citation statements)

References 44 publications

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“…Correlation analyses also showed a significant negative correlation between waist circumference and direct bilirubin levels. Consistent with our results, the literature reports that abdominal obesity alone has been correlated with low serum bilirubin levels 8,11–13,24,25). Choi et al 8).…”

Section: Discussionsupporting

confidence: 93%

“…The relationship between serum direct bilirubin levels and MetS, as demonstrated in our study, has also been shown in many previous studies 8–13). Jo et al 10).…”

Section: Discussionsupporting

confidence: 91%

“…During the past few years, studies have shown that serum bilirubin levels are inversely associated with MetS and systemic inflammation in adults,8–11) children and adolescents 11). It have been reported that especially, abdominal obesity has been correlated with low serum bilirubin levels 11–13). Low serum bilirubin has been proven to be associated with increased carotid intima media thickness8,14) and peripheral arterial disease 15–17).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders

Karadag

Şengül

Enli

et al. 2017

Clin Psychopharmacol Neurosci

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ObjectiveWe investigated the relationship between serum bilirubin levels and metabolic syndrome (MetS), and the longitudinal effects of baseline serum bilirubin concentrations on MetS in patients with schizophrenia spectrum disorders undergoing atypical antipsychotics.MethodsThe sample of this study consisted of 131 patients with schizophrenia spectrum disorders. Waist circumference, blood pressure, and levels of triglycerides, high-density lipoprotein cholesterol, fasting glucose, and insulin were evaluated at baseline and at month six. Serum bilirubin levels were measured at baseline. Serum bilirubin levels of the patients with and without MetS criteria were compared. We also compared patients with high and low bilirubin levels (upper and lower 50th percentiles of serum bilirubin levels) in terms of MetS criteria, MetS frequency, and course of MetS.ResultsSerum direct bilirubin levels were more consistently related to MetS and MetS-related variables. The waist circumference and triglyceride criteria for MetS were significantly related to low serum direct bilirubin at baseline; waist circumference and fasting glucose criteria, and insulin resistance were associated with low serum direct bilirubin at follow-up. MetS diagnosis and the presence of the waist circumference criterion were more frequent at the baseline and the follow-up in low bilirubin group. At the end of the follow-up period, the rate of reverse MetS was significantly higher in the high bilirubin group.ConclusionOur results have suggested that serum direct bilirubin levels showed a more reliable and stable relationship with abdominal obesity for MetS components.in patients with schizophrenia spectrum disorders using antipsychotics. Further studies are required.

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Section: Discussionsupporting

confidence: 93%

“…The relationship between serum direct bilirubin levels and MetS, as demonstrated in our study, has also been shown in many previous studies 8–13). Jo et al 10).…”

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders

Karadag

Şengül

Enli

et al. 2017

Clin Psychopharmacol Neurosci

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“…This observation is supported by other large epidemiological observations showing lower BMI in hyperbilirubinaemic subjects ( [4,28]; see [30] for review). Interestingly, in Gunn rats, a difference in body mass was only found in female rats, which is supported by recent studies in a smaller group of aged female Gunn rats [13] and cross-sectional clinical studies [29] as recently reviewed [30]. A recent short-term weight loss study was effective in significantly increasing bilirubin levels back to the normal reference range.…”

Section: Bmimentioning

confidence: 72%

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

et al. 2013

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Recent epidemiological and clinical data show protection from CVD (cardiovascular disease), all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n=59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n=40) was investigated to further support the presented human data. GS subjects had significantly (P<0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low- and pro-atherogenic LDL subfractions (LDL-1+LDL-2), Apo-B, Apo-B/Apo-A1 ratio and lower IL-6 (interleukin 6) and SAA (serum amyloid A) concentrations (P=0.094). When the control and GS groups were subdivided into younger and older cohorts, older GS subjects demonstrated reduced lipid variables (total cholesterol and LDL-C, TAG and LDL-C subfractions, Apo-B/Apo-A1 ratio; P<0.05; Apo-B: P<0.1) compared with controls. These data were supported by lipid analyses in the rodent model showing that Gunn rat serum had lower total cholesterol (2.29±0.38 compared with 1.27±0.72 mM; P<0.001) and TAG (1.66±0.67 compared with 0.99±0.52 mM; P<0.001) concentrations compared with controls. These findings indicate that the altered lipid profile and the reduced pro-inflammatory status in hyperbilirubinaemic subjects, particularly in the older individuals, probably contribute additionally to the commonly accepted beneficial antioxidant effects of bilirubin in humans.

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“…Another by Guzek et al (2012) and by Kwon et al (2011) showed that there is inverse association of serum bilirubin with metabolic syndrome and insulin resistance . [15][16][17] …”

Section: Discussionmentioning

confidence: 99%

Serum bilirubin level in metabolic syndrome

Shah

Sirajwala

2014

Int J of Biomed & Adv Res

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Inverse Association Between Total Bilirubin and Metabolic Syndrome in Rural Korean Women

Cited by 32 publications

References 44 publications

Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders

Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

Serum bilirubin level in metabolic syndrome

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